Other Characterized Proteins Similar to ilvI

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to ilvI

Finding the characterized proteins for ilvI (acetolactate/acetohydroxybutanoate synthase catalytic subunit) in L-isoleucine biosynthesis

Or see clustering for step ilvI

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of ilvI

HMM TIGR00118
Curated proteins matching acetohydroxy-acid synthase%large
Curated proteins matching acetohydroxy acid synthase%large
Curated proteins matching acetohydroxybutanoate synthase, catalytic subunit
Curated proteins matching acetohydroxybutanoate synthase, catalytic subunit
Curated proteins matching acetohydroxyacid synthase subunit B
Ignore hits to items matching EC 2.2.1.6 when looking for 'other' hits
Ignore hits to CH_124219 when looking for 'other' hits (threonine deaminase [Arxula adeninivorans])
Ignore hits to O53554 when looking for 'other' hits (acetolactate synthase (EC 2.2.1.6). Putative acetolactate synthase large subunit IlvX; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6)
Comment: ilvIH (or ilvGM) is a two-subunit enzyme that forms acetolactate or acetohydroxybutanoate. (S)-2-aceto-2-hydroxybutanoate synthesis is part of isoleucine biosynthesis. Acetolactate synthesis is part of valine or leucine biosynthesis. CH_124129 is probably correct but has limited data and vaguer annotations. IlvX from Mycobacterium tuberculosis (O53554) is ignored because, although annotated with this activity by both SwissProt and BRENDA, we could not find experimental evidence, and it is reported to lack activity (PMID:20884690).

Fetched 7 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 25 other characterized sequences. (Found 32 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for ilvI.)

P45261 acetolactate synthase (EC 2.2.1.6) from Haemophilus influenzae
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
573 amino acids: PaperBLAST, CDD, BRENDA::P45261
70% identical to

b0077 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655
P00893 acetolactate synthase / acetohydroxybutanoate synthase, catalytic subunit (EC 2.2.1.6) from Escherichia coli (strain K12)
P00893 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 574 amino acids: PaperBLAST, CDD

Q5S3P7 acetolactate synthase (EC 2.2.1.6) from Streptomyces cinnamonensis
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
615 amino acids: PaperBLAST, CDD, BRENDA::Q5S3P7
68% identical to

ILVB1_MYCTU / P9WG41 Acetolactate synthase large subunit IlvB1; ALS; Acetohydroxy-acid synthase large subunit; AHAS; EC 2.2.1.6 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WG41 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Mycobacterium tuberculosis
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 618 amino acids: PaperBLAST, CDD

G0ZSE6 acetolactate synthase (EC 2.2.1.6) from Pseudomonas sp.
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
574 amino acids: PaperBLAST, CDD, BRENDA::G0ZSE6
65% identical to

P42463 acetolactate synthase (EC 2.2.1.6) from Corynebacterium glutamicum
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
626 amino acids: PaperBLAST, CDD, BRENDA::P42463
65% identical to

Q5SJ01 acetolactate synthase (EC 2.2.1.6); pyruvate decarboxylase (EC 4.1.1.1) from Thermus thermophilus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
562 amino acids: PaperBLAST, CDD, BRENDA::Q5SJ01
54% identical to

Q8RL88 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Geobacillus stearothermophilus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 572 amino acids: PaperBLAST, CDD, BRENDA::Q8RL88
51% identical to

Q0KCU4 acetohydroxyacid synthase subunit B (EC 2.2.1.6) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 585 amino acids: PaperBLAST, CDD

P37251 acetolactate synthase (EC 2.2.1.6) from Bacillus subtilis
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
574 amino acids: PaperBLAST, CDD, BRENDA::P37251
49% identical to

b3671 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli K-12 substr. MG1655
P08142 acetohydroxy acid synthase I subunit IlvB (EC 2.2.1.6) from Escherichia coli (strain K12)
P08142 acetolactate synthase (subunit 2/2) (EC 2.2.1.6) from Escherichia coli
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 562 amino acids: PaperBLAST, CDD, BRENDA::P08142
46% identical to

ILVG_ECOLI / P0DP90 Acetolactate synthase isozyme 2 large subunit; AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit; EC 2.2.1.6 from Escherichia coli (strain K12)
GB|CAA28573.1 acetolactate synthase isozyme 2 large subunit; EC 2.2.1.6 from Escherichia coli K12
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
548 amino acids: PaperBLAST, CDD

V5Q0Z4 acetolactate synthase (EC 2.2.1.6) from Myosoton aquaticum
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
666 amino acids: PaperBLAST, CDD, BRENDA::V5Q0Z4
46% identical to

Q5VB44 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
646 amino acids: PaperBLAST, CDD, BRENDA::Q5VB44
46% identical to

Q8U2A4 acetolactate synthase (EC 2.2.1.6) from Pyrococcus furiosus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
564 amino acids: PaperBLAST, CDD, BRENDA::Q8U2A4
48% identical to

O08353 acetohydroxy-acid synthase large subunit (EC 2.2.1.6) from Methanococcus aeolicus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 599 amino acids: PaperBLAST, CDD

ILVB_ARATH / P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress)
P17597 acetolactate synthase (EC 2.2.1.6) from Arabidopsis thaliana
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
670 amino acids: PaperBLAST, CDD, BRENDA::P17597
45% identical to

A5X300 acetolactate synthase (EC 2.2.1.6) from Oryza sativa Indica Group
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
644 amino acids: PaperBLAST, CDD, BRENDA::A5X300
45% identical to

Q6K2E8 acetolactate synthase (EC 2.2.1.6) from Oryza sativa
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
644 amino acids: PaperBLAST, CDD, BRENDA::Q6K2E8
45% identical to

Q5VB49 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
655 amino acids: PaperBLAST, CDD, BRENDA::Q5VB49
45% identical to

Q42768 acetolactate synthase (EC 2.2.1.6) from Gossypium hirsutum
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
659 amino acids: PaperBLAST, CDD, BRENDA::Q42768
45% identical to

A0A0M3TGF7 acetolactate synthase (EC 2.2.1.6) from Poa annua
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
643 amino acids: PaperBLAST, CDD, BRENDA::A0A0M3TGF7
45% identical to

A0A0M4NDK0 acetolactate synthase (EC 2.2.1.6) from Poa annua
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
638 amino acids: PaperBLAST, CDD, BRENDA::A0A0M4NDK0
45% identical to

K7TWQ8 acetolactate synthase (EC 2.2.1.6) from Zea mays
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
638 amino acids: PaperBLAST, CDD, BRENDA::K7TWQ8
45% identical to

Q5VB42 acetolactate synthase (EC 2.2.1.6) from Helianthus annuus
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
646 amino acids: PaperBLAST, CDD, BRENDA::Q5VB42
44% identical to

ILVB_YEAST / P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P07342 acetolactate synthase (EC 2.2.1.6) from Saccharomyces cerevisiae
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
687 amino acids: PaperBLAST, CDD, BRENDA::P07342
44% identical to

CH_122628 acetolactate synthase; EC 2.2.1.6 from Emericella nidulans
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
697 amino acids: PaperBLAST, CDD, CharProtDB::CH_122628
44% identical to

G4MMK2 acetolactate synthase (subunit 1/2) (EC 2.2.1.6) from Pyricularia oryzae
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
Heteromeric, 682 amino acids: PaperBLAST, CDD, BRENDA::G4MMK2
43% identical to

CH_123597 acetolactate synthase; EC 2.2.1.6 from Candida albicans
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
683 amino acids: PaperBLAST, CDD, CharProtDB::CH_123597
43% identical to

RF|NP_595382.1 acetolactate synthase catalytic subunit; EC 2.2.1.6 from Schizosaccharomyces pombe
PFams: TPP_enzyme_N, TPP_enzyme_M, TPP_enzyme_C
669 amino acids: PaperBLAST, CDD, CharProtDB::CH_125265
43% identical to