Other Characterized Proteins Similar to leuB

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to leuB

Finding the characterized proteins for leuB (3-methylmalate dehydrogenase / 3-isopropylmalate dehydrogenase) in L-isoleucine biosynthesis

Or see clustering for step leuB

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of leuB

Curated proteins or TIGRFams with EC 1.1.1.85
Ignore hits to P87267 when looking for 'other' hits (3-isopropylmalate dehydrogenase (EC 1.1.1.85))
Comment: The short protein P87267 is misannotated as this in BRENDA, so it is ignored.

Fetched 45 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 17 other characterized sequences. (Found 62 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for leuB.)

Q51945 tartrate dehydrogenase subunit (EC 1.1.1.83; EC 1.1.1.93) from Pseudomonas putida
TTUC_PSEPU / Q51945 Tartrate dehydrogenase/decarboxylase; TDH; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.93; EC 4.1.1.73; EC 1.1.1.83 from Pseudomonas putida (Arthrobacter siderocapsulatus)
PFams: Iso_dh
365 amino acids: PaperBLAST, CDD, SwissProt::Q51945
77% identical to

b1800 D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli K-12 substr. MG1655
P76251 D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli (strain K12)
DMLA_ECOLI / P76251 D-malate dehydrogenase [decarboxylating]; D-malate degradation protein A; D-malate oxidase; EC 1.1.1.83 from Escherichia coli (strain K12)
P76251 D-malate dehydrogenase (decarboxylating) (EC 1.1.1.83) from Escherichia coli
RF|NP_416314 D-malate dehydrogenase [decarboxylating] from Escherichia coli K12
PFams: Iso_dh
361 amino acids: PaperBLAST, CDD

A0A3G6WGL6 L-tartrate dehydrogenase/D-malate dehydrogenase (decarboxylating)/meso-tartrate decarboxylase monomer (EC 1.1.1.83; EC 1.1.1.93) from Cereibacter sphaeroides
PFams: Iso_dh
357 amino acids: PaperBLAST, CDD, metacyc::MONOMER-124344
66% identical to

Q5SIJ1 homoisocitrate dehydrogenase subunit (EC 1.1.1.87) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
HICDH_THET8 / Q5SIJ1 Isocitrate/homoisocitrate dehydrogenase; Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.286 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
HICDH_THET2 / Q72IW9 Isocitrate/homoisocitrate dehydrogenase; Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.286 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Q5SIJ1 homoisocitrate dehydrogenase (EC 1.1.1.87) from Thermus thermophilus
PFams: Iso_dh
334 amino acids: PaperBLAST, CDD, BRENDA::Q5SIJ1
53% identical to

Q58130 3-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
LEU3_METJA / Q58130 3-isopropylmalate/3-methylmalate dehydrogenase; 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; IPMDH; Beta-IPM dehydrogenase; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.85; EC 1.1.1.n5; EC 1.1.1.83 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: Iso_dh
333 amino acids: PaperBLAST, CDD

Q58991 NAD-dependent threo-isocitrate dehydrogenase (EC 1.1.1.87) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
AKSF_METJA / Q58991 Homoisocitrate dehydrogenase; HICDH; Homo(2)-isocitrate/homo(3)-isocitrate dehydrogenase; Isohomocitrate dehydrogenase; IHDH; NAD-dependent threo-isohomocitrate dehydrogenase; EC 1.1.1.87; EC 1.1.1.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58991 methanogen homoaconitase (EC 4.2.1.114) from Methanocaldococcus jannaschii
PFams: Iso_dh
347 amino acids: PaperBLAST, CDD, SwissProt::Q58991
48% identical to

LYS12_YEAST / P40495 Homoisocitrate dehydrogenase, mitochondrial; HIcDH; EC 1.1.1.87 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P40495 homoisocitrate dehydrogenase (EC 1.1.1.87) from Saccharomyces cerevisiae
PFams: Iso_dh
371 amino acids: PaperBLAST, CDD, BRENDA::P40495
46% identical to

Q0X0C1 (2S,3R)-2-[(2-aminophenyl)amino]-3-carboxy-3-hydroxypropanoate dehydrogenase from Streptomyces lasalocidi
PFams: Iso_dh
362 amino acids: PaperBLAST, CDD, metacyc::MONOMER-19585
45% identical to

P94929 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mycobacterium tuberculosis variant bovis
PFams: Iso_dh
336 amino acids: PaperBLAST, CDD

P33197 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Thermus thermophilus
RF|YP_144801.1 isocitrate dehydrogenase (NADP(+)); EC 1.1.1.42 from Thermus thermophilus HB8
PFams: Iso_dh, Isocitrate_DH_C_bact
496 amino acids: PaperBLAST, CDD, BRENDA::P33197
44% identical to

LYS12_SCHPO / O14104 Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.87 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Iso_dh
362 amino acids: PaperBLAST, CDD, SwissProt::O14104
42% identical to

P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.286) from Homo sapiens
IDH3A_HUMAN / P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Homo sapiens (Human)
P50213 isocitrate dehydrogenase (NAD+) (subunit 2/2) (EC 1.1.1.41) from Homo sapiens
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, BRENDA::P50213
42% identical to

LEU3_SULTO / P50455 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; Beta-IPM dehydrogenase; EC 1.1.1.85 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
P50455 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfurisphaera tokodaii
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD

IDH3A_PIG / P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Sus scrofa (Pig)
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, SwissProt::P56471
41% identical to

IDH3A_MOUSE / Q9D6R2 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Mus musculus (Mouse)
Q9D6R2 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Mus musculus
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, BRENDA::Q9D6R2
41% identical to

IDH3A_BOVIN / P41563 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitrate dehydrogenase subunits 3/4; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Bos taurus (Bovine)
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, SwissProt::P41563
41% identical to

Q4JB37 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfolobus acidocaldarius
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD

Q945K7 NAD+-dependent isocitrate dehydrogenase catalytic subunit (EC 1.1.1.286) from Arabidopsis thaliana
IDH5_ARATH / Q945K7 Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial; IDH-V; Isocitric dehydrogenase 5; NAD(+)-specific ICDH 5; EC 1.1.1.41 from Arabidopsis thaliana (Mouse-ear cress)
Q945K7 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana
PFams: Iso_dh
Heteromeric, 374 amino acids: PaperBLAST, CDD, BRENDA::Q945K7
41% identical to

Q4JB37 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfolobus acidocaldarius
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD

Q5JFV8 isocitrate-homoisocitrate dehydrogenase (EC 1.1.1.286) from Thermococcus kodakarensis
PFams: Iso_dh
347 amino acids: PaperBLAST, CDD, BRENDA::Q5JFV8
41% identical to

LEU3_HALVD / D4GYE8 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
PFams: Iso_dh
324 amino acids: PaperBLAST, CDD

IDH3A_RAT / Q99NA5 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Rattus norvegicus (Rat)
Q99NA5 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Rattus norvegicus
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, BRENDA::Q99NA5
41% identical to

IDH6_ARATH / Q8LG77 Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial; IDH-VI; Isocitric dehydrogenase 6; NAD(+)-specific ICDH 6; EC 1.1.1.41 from Arabidopsis thaliana (Mouse-ear cress)
Q8LG77 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana
PFams: Iso_dh
Heteromeric, 374 amino acids: PaperBLAST, CDD, BRENDA::Q8LG77
41% identical to

Q4JB37 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfolobus acidocaldarius
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD

HICDH_PYRHO / O59394 Isocitrate/homoisocitrate dehydrogenase; HICDH; Beta-decarboxylating dehydrogenase; EC 1.1.1.286 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
PFams: Iso_dh
345 amino acids: PaperBLAST, CDD, SwissProt::O59394
40% identical to