Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for leuB (3-methylmalate dehydrogenase / 3-isopropylmalate dehydrogenase) in L-isoleucine biosynthesis

Or see other characterized proteins similar to leuB

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of leuB

Curated proteins or TIGRFams with EC 1.1.1.85
Ignore hits to P87267 when looking for 'other' hits (3-isopropylmalate dehydrogenase (EC 1.1.1.85))
Comment: The short protein P87267 is misannotated as this in BRENDA, so it is ignored.

Fetched 45 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 45 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by cluster

Acidithiobacillus ferrooxidans

LEU3_ACIFR / Q56268 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Acidithiobacillus ferrooxidans (Thiobacillus ferrooxidans)
Q56268 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Acidithiobacillus ferrooxidans
PFams: Iso_dh
358 amino acids: PaperBLAST, CDD (Cluster 1)

Agrobacterium tumefaciens

P24404 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Agrobacterium tumefaciens
PFams: Iso_dh
370 amino acids: PaperBLAST, CDD (Cluster 1)

Alternaria alternata

AMT6_ALTAL / C9K7B7 3-isopropylmalate dehydrogenase AMT6; AM-toxin biosynthesis protein 6; EC 1.1.1.85 from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Iso_dh
373 amino acids: PaperBLAST, CDD (Cluster 1)

Arabidopsis thaliana

LEU32_ARATH / P93832 3-isopropylmalate dehydrogenase 2, chloroplastic; 3-IPM-DH 2; AtIMDH2; AtIMDH3; IMDH 2; Beta-IPM dehydrogenase 2; Isopropylmalate dehydrogenase 2; AtIMD2; EC 1.1.1.85 from Arabidopsis thaliana (Mouse-ear cress)
P93832 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana
PFams: Iso_dh
405 amino acids: PaperBLAST, CDD (Cluster 1)

Q9FMT1 isopropylmalate dehydrogenase 3 (EC 1.1.1.85) from Arabidopsis thaliana
LEU31_ARATH / Q9FMT1 3-isopropylmalate dehydrogenase 1, chloroplastic; 3-IPM-DH 1; AtIMDH1; IMDH 1; Beta-IPM dehydrogenase 1; Isopropylmalate dehydrogenase 1; AtIMD1; Methylthioalkylmalate dehydrogenase 1; EC 1.1.1.85 from Arabidopsis thaliana (Mouse-ear cress)
Q9FMT1 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana
PFams: Iso_dh
409 amino acids: PaperBLAST, CDD (Cluster 1)

LEU33_ARATH / Q9SA14 3-isopropylmalate dehydrogenase 3, chloroplastic; 3-IPM-DH 3; AtIMDH2; AtIMDH3; IMDH 3; Beta-IPM dehydrogenase 3; Isopropylmalate dehydrogenase 3; AtIMD3; EC 1.1.1.85 from Arabidopsis thaliana (Mouse-ear cress)
Q9SA14 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana
PFams: Iso_dh
404 amino acids: PaperBLAST, CDD (Cluster 1)

Arthrospira platensis

Q00412 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arthrospira platensis
PFams: Iso_dh
355 amino acids: PaperBLAST, CDD (Cluster 1)

Aspergillus niger

P87256 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Aspergillus niger
PFams: Iso_dh
363 amino acids: PaperBLAST, CDD (Cluster 1)

Aspergillus rugulosus

K0E689 3-(4-hydroxybenzyl)-malate dehydrogenase from Aspergillus rugulosus
HTYC_ASPRU / K0E689 Isopropyl malate dehydrogenase htyC; L-homotyrosine biosynthetic cluster protein C; EC 1.1.1.85 from Aspergillus rugulosus (Emericella rugulosa)
PFams: Iso_dh
366 amino acids: PaperBLAST, CDD (Cluster 1)

Azotobacter vinelandii

P96197 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Azotobacter vinelandii
PFams: Iso_dh, Iso_dh
360 amino acids: PaperBLAST, CDD (Cluster 1)

Bacteroides fragilis

P54354 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Bacteroides fragilis
PFams: Iso_dh
353 amino acids: PaperBLAST, CDD (Cluster 1)

Brassica napus

P29102 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Brassica napus
PFams: Iso_dh
406 amino acids: PaperBLAST, CDD (Cluster 1)

Candida albicans

CH_122857 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Candida albicans
PFams: Iso_dh
373 amino acids: PaperBLAST, CDD (Cluster 1)

Candida maltosa

P07139 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Candida maltosa
PFams: Iso_dh
373 amino acids: PaperBLAST, CDD (Cluster 1)

Clostridium pasteurianum

P31958 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Clostridium pasteurianum
PFams: Iso_dh
357 amino acids: PaperBLAST, CDD (Cluster 1)

Cyberlindnera jadinii

P08791 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Cyberlindnera jadinii
PFams: Iso_dh
363 amino acids: PaperBLAST, CDD (Cluster 1)

Eremothecium gossypii

O60027 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Eremothecium gossypii
PFams: Iso_dh
372 amino acids: PaperBLAST, CDD (Cluster 1)

Escherichia coli

b0073 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli K-12 substr. MG1655
P30125 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli (strain K12)
LEU3_ECOLI / P30125 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Escherichia coli (strain K12)
P30125 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli
PFams: Iso_dh
363 amino acids: PaperBLAST, CDD (Cluster 1)

b1800 D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli K-12 substr. MG1655
P76251 D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli (strain K12)
DMLA_ECOLI / P76251 D-malate dehydrogenase [decarboxylating]; D-malate degradation protein A; D-malate oxidase; EC 1.1.1.83 from Escherichia coli (strain K12)
P76251 D-malate dehydrogenase (decarboxylating) (EC 1.1.1.83) from Escherichia coli
RF|NP_416314 D-malate dehydrogenase [decarboxylating] from Escherichia coli K12
PFams: Iso_dh
361 amino acids: PaperBLAST, CDD (Cluster 1)

Glarea lozoyensis

GLOI_GLAL2 / S3DB74 3-isopropylmalate dehydrogenase gloI; L-homotyrosine biosynthesis sub-cluster protein gloI; Pneumocandin biosynthesis cluster protein I; EC 1.1.1.85 from Glarea lozoyensis (strain ATCC 20868 / MF5171)
PFams: Iso_dh
373 amino acids: PaperBLAST, CDD (Cluster 1)

Haemophilus influenzae

P43860 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Haemophilus influenzae
PFams: Iso_dh
358 amino acids: PaperBLAST, CDD (Cluster 1)

Haloferax volcanii

LEU3_HALVD / D4GYE8 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
PFams: Iso_dh
324 amino acids: PaperBLAST, CDD (Cluster 1)

Kazachstania humilis

Q6PY58 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Kazachstania humilis
PFams: Iso_dh
363 amino acids: PaperBLAST, CDD (Cluster 1)

Leptospira interrogans

P24015 β-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
P24015 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Leptospira interrogans
PFams: Iso_dh
358 amino acids: PaperBLAST, CDD (Cluster 1)

Methanocaldococcus jannaschii

Q58130 3-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
LEU3_METJA / Q58130 3-isopropylmalate/3-methylmalate dehydrogenase; 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; IPMDH; Beta-IPM dehydrogenase; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.85; EC 1.1.1.n5; EC 1.1.1.83 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: Iso_dh
333 amino acids: PaperBLAST, CDD (Cluster 1)

Mucor circinelloides

S2J6B8 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mucor circinelloides
PFams: Iso_dh
375 amino acids: PaperBLAST, CDD (Cluster 1)

Mycobacterium tuberculosis

P94929 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mycobacterium tuberculosis variant bovis
PFams: Iso_dh
336 amino acids: PaperBLAST, CDD (Cluster 1)

LEU3_MYCTU / P9WKK9 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Iso_dh
336 amino acids: PaperBLAST, CDD (Cluster 1)

Nostoc punctiforme

B2J8P1 2-benzyl-3-hydroxybutanedioate dehydrogenase (EC 1.1.1.85) from Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
PFams: Iso_dh
363 amino acids: PaperBLAST, CDD (Cluster 1)

Ogataea angusta

P34733 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Ogataea angusta
PFams: Iso_dh
362 amino acids: PaperBLAST, CDD (Cluster 1)

Saccharomyces cerevisiae

P04173 3-isopropylmalate dehydrogenase monomer (EC 1.1.1.85) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
PFams: Iso_dh
364 amino acids: PaperBLAST, CDD (Cluster 1)

Salmonella enterica

LEU3_SALTY / P37412 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P37412 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: Iso_dh
363 amino acids: PaperBLAST, CDD (Cluster 1)

Salmonella typhimurium

Scheffersomyces stipitis

O94114 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Scheffersomyces stipitis
PFams: Iso_dh
373 amino acids: PaperBLAST, CDD (Cluster 1)

Schizosaccharomyces pombe

RF|NP_595804.2 3-isopropylmalate dehydrogenase Leu1; EC 1.1.1.85 from Schizosaccharomyces pombe
PFams: Iso_dh
371 amino acids: PaperBLAST, CDD (Cluster 1)

Shewanella benthica

D2YZL2 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Shewanella benthica
PFams: Iso_dh
364 amino acids: PaperBLAST, CDD (Cluster 1)

Shewanella oneidensis

Q8E9N3 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Shewanella oneidensis
PFams: Iso_dh
364 amino acids: PaperBLAST, CDD (Cluster 1)

Sulfolobus acidocaldarius

Q4JB37 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfolobus acidocaldarius
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD (Cluster 1)

Sulfurisphaera tokodaii

LEU3_SULTO / P50455 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; Beta-IPM dehydrogenase; EC 1.1.1.85 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
P50455 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfurisphaera tokodaii
PFams: Iso_dh
337 amino acids: PaperBLAST, CDD (Cluster 1)

Thermus aquaticus

P24098 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus aquaticus
PFams: Iso_dh
344 amino acids: PaperBLAST, CDD (Cluster 1)

Thermus thermophilus

P61494 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus
PFams: Iso_dh
345 amino acids: PaperBLAST, CDD (Cluster 1)

P61495 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus
PFams: Iso_dh
345 amino acids: PaperBLAST, CDD (Cluster 1)

LEU3_THET8 / Q5SIY4 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Q5SIY4 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus
PFams: Iso_dh
345 amino acids: PaperBLAST, CDD (Cluster 1)

Weizmannia coagulans

LEU3_WEICA / P12010 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Weizmannia coagulans (Bacillus coagulans)
PFams: Iso_dh
366 amino acids: PaperBLAST, CDD (Cluster 1)

Zymoseptoria tritici

Q9Y897 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Zymoseptoria tritici
PFams: Iso_dh
365 amino acids: PaperBLAST, CDD (Cluster 1)

[Candida] boidinii

Q01987 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from [Candida] boidinii
PFams: Iso_dh
365 amino acids: PaperBLAST, CDD (Cluster 1)