Other Characterized Proteins Similar to leuD

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to leuD

Finding the characterized proteins for leuD (3-isopropylmalate dehydaratase / citramalate isomerase, small subunit) in L-isoleucine biosynthesis

Or see clustering for step leuD

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of leuD

Curated proteins matching citramalate isomerase small subunit
Curated proteins matching 3-isopropylmalate dehydratase small subunit
Curated proteins matching 3-isopropylmalate dehydratase%LeuD
HMM TIGR00171
HMM TIGR02084
HMM TIGR02087
Ignore hits to Q0QLE1 when looking for 'other' hits (2,3-dimethylmalate dehydratase small subunit; EC 4.2.1.85. dimethylmaleate hydratase subunit B (EC 4.2.1.85))
Ignore hits to items matching EC 4.2.1.33 when looking for 'other' hits
Ignore hits to items matching EC 4.2.1.35 when looking for 'other' hits
Ignore hits to CH_122621 when looking for 'other' hits (alpha isopropylmalate isomerase (Eurofung))
UniProt sequence Q845W4: RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031}; EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031}; Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031};
UniProt sequence A0A1X9Z766: RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031}; EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031}; Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031};
Comment: A mutant of BAC65258.1 (Q845W4) was shown to be a leucine auxotroph in PMC155387. CA265_RS15840 (A0A1X9Z766) from Pedobacter sp. GW460-11-11-14-LB5 is important for fitness unless amino acids are added.

Fetched 17 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 7 other characterized sequences. (Found 22 hits including self hits.)

Removing ignored items reduces this to 1 close sequences.

There are also 6 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for leuD.)

K0E2G4 2-(4-hydroxybenzyl)-malate isomerase from Aspergillus rugulosus
HTYD_ASPRU / K0E2G4 Aconitase htyD; L-homotyrosine biosynthetic cluster protein D; EC 4.2.1.- from Aspergillus rugulosus (Emericella rugulosa)
PFams: Aconitase, Aconitase, Aconitase_C
878 amino acids: PaperBLAST, CDD, SwissProt::K0E2G4
50% identical to

ACON3_ASPFU / Q4WBR0 Putative aconitate hydratase; Aconitase 3; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
PFams: Aconitase, Aconitase, Aconitase_C
811 amino acids: PaperBLAST, CDD

HMM-only sequences

(Since these sequences' annotations are outside the definition for leuD, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

AMT82_ALTAL / C9K7I3 Aconitase AMT8-2; AM-toxin biosynthesis protein 8-2; EC 4.2.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aconitase, Aconitase, Aconitase_C
843 amino acids: PaperBLAST, CDD

Q0QFQ6 maleate hydratase small subunit (EC 4.2.1.31) from Pseudomonas alcaligenes
Q0QFQ6 maleate hydratase (subunit 1/2) (EC 4.2.1.31) from Pseudomonas alcaligenes
PFams: Aconitase_C
Heteromeric, 213 amino acids: PaperBLAST, CDD

Q9ZND9 homoaconitase small subunit (EC 4.2.1.36) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
HACB_THET2 / Q9ZND9 Homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.36 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
PFams: Aconitase_C
Heteromeric, 163 amino acids: PaperBLAST, CDD

Q58667 homoaconitase β subunit (EC 4.2.1.36) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
HACB_METJA / Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: Aconitase_2_N, Aconitase_C
Heteromeric, 170 amino acids: PaperBLAST, CDD

AMT8_ALTAL / C9K7B9 Aconitase AMT8; AM-toxin biosynthesis protein 8; EC 4.2.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aconitase, Aconitase, Aconitase_C
840 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for leuD.)

CH_122621 alpha isopropylmalate isomerase (Eurofung) from Emericella nidulans
PFams: Aconitase, Aconitase_C
772 amino acids: PaperBLAST, CDD, CharProtDB::CH_122621
58% identical to

LEUD_RHIL3 / Q1MA52 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Rhizobium leguminosarum bv. viciae (strain 3841)
PFams: Aconitase_C
Heteromeric, 202 amino acids: PaperBLAST, CDD

Q8F4E5 isopropylmalate isomerase small subunit (EC 4.2.1.35) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
PFams: Aconitase_C
Heteromeric, 206 amino acids: PaperBLAST, CDD, metacyc::MONOMER-11897
58% identical to

Q845W4 3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031}; EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031}; Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031}; Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031}
216 amino acids: PaperBLAST, CDD

LEUC_YEAST / P07264 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Aconitase, Aconitase_C
779 amino acids: PaperBLAST, CDD, SwissProt::P07264
54% identical to

Q0QLE1 dimethylmaleate hydratase subunit B (EC 4.2.1.85) from Eubacterium barkeri
DMDB_EUBBA / Q0QLE1 2,3-dimethylmalate dehydratase small subunit; EC 4.2.1.85 from Eubacterium barkeri (Clostridium barkeri)
PFams: Aconitase_C
Heteromeric, 163 amino acids: PaperBLAST, CDD, SwissProt::Q0QLE1
54% identical to

Q58673 isopropylmalate isomerase small subunit (EC 4.2.1.35) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
LEUD_METJA / Q58673 Isopropylmalate/citramalate isomerase small subunit; (R)-2-methylmalate dehydratase; (R)-citramalate dehydratase; 3-isopropylmalate dehydratase; Alpha-isopropylmalate dehydratase; Citraconate hydratase; Isopropylmalate isomerase; IPMI; Maleate hydratase; Malease; EC 4.2.1.33; EC 4.2.1.35; EC 4.2.1.31 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58673 3-isopropylmalate dehydratase (EC 4.2.1.33) from Methanocaldococcus jannaschii
PFams: Aconitase_C
Heteromeric, 168 amino acids: PaperBLAST, CDD

O59393 3-isopropylmalate dehydratase (EC 4.2.1.33) from Pyrococcus horikoshii
PFams: Aconitase_C
163 amino acids: PaperBLAST, CDD, BRENDA::O59393
48% identical to

GLOJ_GLAL2 / S3E7P8 3-isopropylmalate dehydratase large subunit gloJ; L-homotyrosine biosynthesis sub-cluster protein gloJ; Pneumocandin biosynthesis cluster protein J; EC 4.2.1.33 from Glarea lozoyensis (strain ATCC 20868 / MF5171)
PFams: Aconitase, Aconitase_C
880 amino acids: PaperBLAST, CDD, SwissProt::S3E7P8
46% identical to