Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for leuD (3-isopropylmalate dehydaratase / citramalate isomerase, small subunit) in L-isoleucine biosynthesis

Or see other characterized proteins similar to leuD

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of leuD

Curated proteins matching citramalate isomerase small subunit
Curated proteins matching 3-isopropylmalate dehydratase small subunit
Curated proteins matching 3-isopropylmalate dehydratase%LeuD
HMM TIGR00171
HMM TIGR02084
HMM TIGR02087
Ignore hits to Q0QLE1 when looking for 'other' hits (2,3-dimethylmalate dehydratase small subunit; EC 4.2.1.85. dimethylmaleate hydratase subunit B (EC 4.2.1.85))
Ignore hits to items matching EC 4.2.1.33 when looking for 'other' hits
Ignore hits to items matching EC 4.2.1.35 when looking for 'other' hits
Ignore hits to CH_122621 when looking for 'other' hits (alpha isopropylmalate isomerase (Eurofung))
UniProt sequence Q845W4: RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031}; EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031}; Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031};
UniProt sequence A0A1X9Z766: RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031}; EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031}; Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031};
Comment: A mutant of BAC65258.1 (Q845W4) was shown to be a leucine auxotroph in PMC155387. CA265_RS15840 (A0A1X9Z766) from Pedobacter sp. GW460-11-11-14-LB5 is important for fitness unless amino acids are added.

Fetched 17 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 17 of these sequences

Found 4 clusters of similar sequences. Download as table or as draft rules or view by cluster

Alternaria alternata

AMT8_ALTAL / C9K7B9 Aconitase AMT8; AM-toxin biosynthesis protein 8; EC 4.2.1.- (from HMM only) from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aconitase, Aconitase, Aconitase_C
840 amino acids: PaperBLAST, CDD (Cluster 3)

AMT82_ALTAL / C9K7I3 Aconitase AMT8-2; AM-toxin biosynthesis protein 8-2; EC 4.2.1.- (from HMM only) from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: Aconitase, Aconitase, Aconitase_C
843 amino acids: PaperBLAST, CDD (Cluster 3)

Arabidopsis thaliana

LEUD2_ARATH / Q9LYT7 3-isopropylmalate dehydratase small subunit 3; 2-(omega-methylthio)alkylmalate dehydratase small subunit 3; AtLEUD2; Isopropylmalate isomerase 1; Isopropylmalate isomerase small subunit 3; IPMI SSU3; Methylthioalkylmalate isomerase small subunit; MAM-IS; EC 4.2.1.33; EC 4.2.1.170 from Arabidopsis thaliana (Mouse-ear cress)
Q9LYT7 2-(omega-methylthio)alkylmalate dehydratase (subunit 1/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana
PFams: Aconitase_C
Heteromeric, 253 amino acids: PaperBLAST, CDD (Cluster 2)

Q9ZW84 isopropylmalate isomerase, small subunit (EC 4.2.1.170) from Arabidopsis thaliana
LEUD1_ARATH / Q9ZW84 3-isopropylmalate dehydratase small subunit 2; 2-(omega-methylthio)alkylmalate dehydratase small subunit 2; AtLEUD1; Isopropylmalate isomerase 2; Isopropylmalate isomerase small subunit 2; IPMI SSU2; Methylthioalkylmalate isomerase small subunit; MAM-IS; EC 4.2.1.33; EC 4.2.1.170 from Arabidopsis thaliana (Mouse-ear cress)
Q9ZW84 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana
PFams: Aconitase_C
Heteromeric, 256 amino acids: PaperBLAST, CDD (Cluster 2)

Q9ZW85 isopropylmalate isomerase, small subunit (EC 4.2.1.33) from Arabidopsis thaliana
LEUD3_ARATH / Q9ZW85 3-isopropylmalate dehydratase small subunit 1; AtLEUD3; Isopropylmalate isomerase small subunit 1; IPMI SSU1; EC 4.2.1.33 from Arabidopsis thaliana (Mouse-ear cress)
Q9ZW85 2-(omega-methylthio)alkylmalate dehydratase (subunit 1/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana
PFams: Aconitase_C
Heteromeric, 251 amino acids: PaperBLAST, CDD (Cluster 2)

Aspergillus fumigatus

ACON3_ASPFU / Q4WBR0 Putative aconitate hydratase; Aconitase 3; EC 4.2.1.- (from HMM only) from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
PFams: Aconitase, Aconitase, Aconitase_C
811 amino acids: PaperBLAST, CDD (Cluster 3)

Corynebacterium glutamicum

LEUD_CORGL / Q8NQV7 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: Aconitase_C
Heteromeric, 197 amino acids: PaperBLAST, CDD (Cluster 1)

Escherichia coli

b0071 3-isopropylmalate dehydratase subunit LeuD (EC 4.2.1.33) from Escherichia coli K-12 substr. MG1655
P30126 3-isopropylmalate dehydratase subunit LeuD (EC 4.2.1.33) from Escherichia coli (strain K12)
PFams: Aconitase_C
Heteromeric, 201 amino acids: PaperBLAST, CDD (Cluster 1)

Methanocaldococcus jannaschii

Q58673 isopropylmalate isomerase small subunit (EC 4.2.1.35) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
LEUD_METJA / Q58673 Isopropylmalate/citramalate isomerase small subunit; (R)-2-methylmalate dehydratase; (R)-citramalate dehydratase; 3-isopropylmalate dehydratase; Alpha-isopropylmalate dehydratase; Citraconate hydratase; Isopropylmalate isomerase; IPMI; Maleate hydratase; Malease; EC 4.2.1.33; EC 4.2.1.35; EC 4.2.1.31 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58673 3-isopropylmalate dehydratase (EC 4.2.1.33) from Methanocaldococcus jannaschii
PFams: Aconitase_C
Heteromeric, 168 amino acids: PaperBLAST, CDD (Cluster 1)

Q58667 homoaconitase β subunit (EC 4.2.1.36) (from HMM only) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
HACB_METJA / Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: Aconitase_2_N, Aconitase_C
Heteromeric, 170 amino acids: PaperBLAST, CDD (Cluster 4)

Mycobacterium bovis

LEUD_MYCBO / P65278 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
P9WK95 3-isopropylmalate dehydratase (EC 4.2.1.33) from Mycobacterium tuberculosis
PFams: Aconitase_C
Heteromeric, 198 amino acids: PaperBLAST, CDD (Cluster 1)

Mycobacterium tuberculosis

Organism unknown

A0A1X9Z766 3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031}; EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031}; Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031}; Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031}
195 amino acids: PaperBLAST, CDD (Cluster 1)

Q845W4 3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031}; EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031}; Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031}; Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031}; AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031}
216 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudomonas alcaligenes

Q0QFQ6 maleate hydratase small subunit (EC 4.2.1.31) from Pseudomonas alcaligenes
Q0QFQ6 maleate hydratase (subunit 1/2) (EC 4.2.1.31) (from HMM only) from Pseudomonas alcaligenes
PFams: Aconitase_C
Heteromeric, 213 amino acids: PaperBLAST, CDD (Cluster 1)

Rhizobium leguminosarum

LEUD_RHIL3 / Q1MA52 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Rhizobium leguminosarum bv. viciae (strain 3841)
PFams: Aconitase_C
Heteromeric, 202 amino acids: PaperBLAST, CDD (Cluster 1)

Salmonella typhimurium

LEUD1_SALTY / P04787 3-isopropylmalate dehydratase small subunit 1; Alpha-IPM isomerase 1; IPMI 1; Isopropylmalate isomerase 1; EC 4.2.1.33 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Aconitase_C
Heteromeric, 201 amino acids: PaperBLAST, CDD (Cluster 1)

Thermus thermophilus

Q9ZND9 homoaconitase small subunit (EC 4.2.1.36) (from HMM only) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
HACB_THET2 / Q9ZND9 Homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.36 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
PFams: Aconitase_C
Heteromeric, 163 amino acids: PaperBLAST, CDD (Cluster 4)