Other Characterized Proteins Similar to prpE

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to prpE

Finding the characterized proteins for prpE (propionyl-CoA synthetase) in L-isoleucine biosynthesis

Or see clustering for step prpE

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of prpE

Curated proteins matching propionyl-CoA synthetase
Curated proteins matching propionate--CoA ligase
Curated proteins or TIGRFams with EC 6.2.1.17
Ignore hits to Q8ZKF6 when looking for 'other' hits (Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1)
Comment: Q8ZKF6 is very similar to E. coli acs and likely has this activity, so it is ignored.

Fetched 20 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 48 other characterized sequences. (Found 68 hits including self hits.)

Removing ignored items reduces this to 47 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for prpE.)

HPCAS_SULTO / Q973W5 3-hydroxypropionyl-coenzyme A synthetase; 3-hydroxypropionyl-CoA synthetase; EC 6.2.1.36 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Q973W5 3-hydroxypropionyl-CoA synthase (EC 6.2.1.36) from Sulfurisphaera tokodaii
PFams: ACAS_N, AMP-binding, AMP-binding_C
659 amino acids: PaperBLAST, CDD, SwissProt::Q973W5
76% identical to

A4YGR1 3-hydroxypropionyl-CoA synthetase subunit (EC 6.2.1.36) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
HPCAS_METS5 / A4YGR1 3-hydroxypropionyl-coenzyme A synthetase; 3-hydroxypropionyl-CoA synthetase; EC 6.2.1.36 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YGR1 propionate-CoA ligase (EC 6.2.1.17); 3-hydroxypropionyl-CoA synthase (EC 6.2.1.36) from Metallosphaera sedula
PFams: ACAS_N, AMP-binding, AMP-binding_C
661 amino acids: PaperBLAST, CDD

AEE7_ARATH / Q8VZF1 Acetate/butyrate--CoA ligase AAE7, peroxisomal; AMP-binding protein 7; AtAMPBP7; Acetyl-CoA synthetase; Acyl-activating enzyme 7; Butyryl-CoA synthetase; Protein ACETATE NON-UTILIZING 1; EC 6.2.1.1; EC 6.2.1.2 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
569 amino acids: PaperBLAST, CDD, SwissProt::Q8VZF1
74% identical to

CCL3_HUMLU / M4IS88 Acetate--CoA ligase CCL3; HlCCL3; 2-methylbutanoate--CoA ligase CCL4; 2-methylpropanoate--CoA ligase CCL4; Butanoate--CoA ligase CCL3; Hexanoate--CoA ligase CCL3; Isovalerate--CoA ligase CCL3; Pentanoate--CoA ligase CCL3; Propionate--CoA ligase CCL3; EC 6.2.1.1; EC 6.2.1.-; EC 6.2.1.17 from Humulus lupulus (European hop)
PFams: AMP-binding, AMP-binding_C
568 amino acids: PaperBLAST, CDD

AO356_18695 Acetyl-coenzyme A synthetase (EC 6.2.1.1) from Pseudomonas fluorescens FW300-N2C3
PFams: ACAS_N, AMP-binding, AMP-binding_C
651 amino acids: PaperBLAST, CDD, reanno::pseudo5_N2C3_1:AO356_18695
68% identical to

b4069 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.1; EC 6.2.1.17) from Escherichia coli K-12 substr. MG1655
P27550 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.17; EC 6.2.1.1) from Escherichia coli (strain K12)
ACSA_ECOLI / P27550 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Escherichia coli (strain K12)
PFams: ACAS_N, AMP-binding, AMP-binding_C
652 amino acids: PaperBLAST, CDD

AO353_03060 Acetyl-coenzyme A synthetase (EC 6.2.1.1) from Pseudomonas fluorescens FW300-N2E3
PFams: ACAS_N, AMP-binding, AMP-binding_C
651 amino acids: PaperBLAST, CDD, reanno::pseudo3_N2E3:AO353_03060
67% identical to

AAE5_ARATH / Q9FFE6 Probable acyl-activating enzyme 5, peroxisomal; AMP-binding protein 5; AtAMPBP5; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
552 amino acids: PaperBLAST, CDD, SwissProt::Q9FFE6
67% identical to

M4IQQ5 isobutanoate/2-methylbutanoate--CoA ligase (EC 6.2.1.1) from Humulus lupulus
CCL4_HUMLU / M4IQQ5 2-methylpropanoate--CoA ligase CCL4; HlCCL4; 2-methylbutanoate--CoA ligase CCL4; Butanoate--CoA ligase CCL3; Propionate--CoA ligase CCL3; EC 6.2.1.-; EC 6.2.1.17 from Humulus lupulus (European hop)
PFams: AMP-binding, AMP-binding_C
556 amino acids: PaperBLAST, CDD

AAE6_ARATH / Q9FFE9 Probable acyl-activating enzyme 6; AMP-binding protein 6; AtAMPBP6; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
550 amino acids: PaperBLAST, CDD, SwissProt::Q9FFE9
67% identical to

AAE8_ARATH / Q9LQS1 Probable acyl-activating enzyme 8; AMP-binding protein 8; AtAMPBP8; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
544 amino acids: PaperBLAST, CDD, SwissProt::Q9LQS1
66% identical to

AEE10_ARATH / Q9LPK7 Probable acyl-activating enzyme 10; AMP-binding protein 10; AtAMPBP10; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
549 amino acids: PaperBLAST, CDD, SwissProt::Q9LPK7
62% identical to

AEE9_ARATH / Q9LPK6 Probable acyl-activating enzyme 9; AMP-binding protein 9; AtAMPBP9; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
550 amino acids: PaperBLAST, CDD, SwissProt::Q9LPK6
62% identical to

AAE4_ARATH / O80658 Probable acyl-activating enzyme 4; AMP-binding protein 4; AtAMPBP4; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
545 amino acids: PaperBLAST, CDD, SwissProt::O80658
61% identical to

ACSM4_RAT / Q7TN78 Acyl-coenzyme A synthetase ACSM4, mitochondrial; Olfactory specific medium-chain acyl CoA synthetase; O-MACS; EC 6.2.1.2 from Rattus norvegicus (Rat)
PFams: AMP-binding, AMP-binding_C
580 amino acids: PaperBLAST, CDD, SwissProt::Q7TN78
59% identical to

ACSM3_MOUSE / Q3UNX5 Acyl-coenzyme A synthetase ACSM3, mitochondrial; Acyl-CoA synthetase medium-chain family member 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle-chain acyl-CoA synthetase 3; Propionate--CoA ligase; Protein SA homolog; EC 6.2.1.2; EC 6.2.1.17 from Mus musculus (Mouse)
PFams: AMP-binding, AMP-binding_C
580 amino acids: PaperBLAST, CDD

ACSM5_HUMAN / Q6NUN0 Acyl-coenzyme A synthetase ACSM5, mitochondrial; Acyl-CoA synthetase medium-chain family member 5; EC 6.2.1.2 from Homo sapiens (Human)
PFams: AMP-binding, AMP-binding_C
579 amino acids: PaperBLAST, CDD, SwissProt::Q6NUN0
61% identical to

ACSM3_HUMAN / Q53FZ2 Acyl-coenzyme A synthetase ACSM3, mitochondrial; Acyl-CoA synthetase medium-chain family member 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle-chain acyl-CoA synthetase 3; Propionate--CoA ligase; Protein SA homolog; EC 6.2.1.2; EC 6.2.1.17 from Homo sapiens (Human)
PFams: AMP-binding, AMP-binding_C
586 amino acids: PaperBLAST, CDD

ACS_ARATH / B9DGD6 Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; Acetate--CoA ligase; Acetyl-CoA synthetase; EC 6.2.1.1 from Arabidopsis thaliana (Mouse-ear cress)
B9DGD6 acetate-CoA ligase (EC 6.2.1.1) from Arabidopsis thaliana
PFams: ACAS_N, AMP-binding, AMP-binding_C
743 amino acids: PaperBLAST, CDD, BRENDA::B9DGD6
56% identical to

Q9NR19 acetyl-coA synthetase (EC 6.2.1.1) from Homo sapiens
ACSA_HUMAN / Q9NR19 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human)
Q9NR19 acetate-CoA ligase (EC 6.2.1.1) from Homo sapiens
PFams: ACAS_N, AMP-binding, AMP-binding_C
701 amino acids: PaperBLAST, CDD

Q5LVM3 3-(methylthio)propionyl-CoA ligase (EC 6.2.1.44) from Ruegeria pomeroyi
PFams: AMP-binding, AMP-binding_C
542 amino acids: PaperBLAST, CDD, BRENDA::Q5LVM3
54% identical to

Q2LWR8 acetate—CoA ligase (EC 6.2.1.1) from Syntrophus aciditrophicus (strain SB)
PFams: ACAS_N, AMP-binding, AMP-binding_C
656 amino acids: PaperBLAST, CDD, metacyc::MONOMER-21856
54% identical to

ACS2A_HUMAN / Q08AH3 Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Acyl-CoA synthetase medium-chain family member 2A; Benzoate--CoA ligase; Butyrate--CoA ligase 2A; Butyryl-coenzyme A synthetase 2A; Middle-chain acyl-CoA synthetase 2A; EC 6.2.1.2; EC 6.2.1.25 from Homo sapiens (Human)
PFams: AMP-binding, AMP-binding_C
577 amino acids: PaperBLAST, CDD, SwissProt::Q08AH3
55% identical to

AAE1_ARATH / F4HUK6 Butanoate--CoA ligase AAE1; 4-methylpentanoate--CoA ligase AAE2; AMP-binding protein 1; AtAMPBP1; Acyl-activating enzyme 1, peroxisomal; Hexanoate--CoA ligase CCL3; Pentanoate--CoA ligase CCL3; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
556 amino acids: PaperBLAST, CDD, SwissProt::F4HUK6
54% identical to

ACS2B_HUMAN / Q68CK6 Acyl-coenzyme A synthetase ACSM2B, mitochondrial; Acyl-CoA synthetase medium-chain family member 2B; Benzoate--CoA ligase; Butyrate--CoA ligase 2B; Butyryl-coenzyme A synthetase 2B; Middle-chain acyl-CoA synthetase 2B; Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A; EC 6.2.1.2; EC 6.2.1.25 from Homo sapiens (Human)
PFams: AMP-binding, AMP-binding_C
577 amino acids: PaperBLAST, CDD, SwissProt::Q68CK6
55% identical to

Q9HWI3 3-(methylthio)propionyl-CoA ligase (EC 6.2.1.44) from Pseudomonas aeruginosa
PFams: AMP-binding, AMP-binding_C
540 amino acids: PaperBLAST, CDD, BRENDA::Q9HWI3
54% identical to

AAE2_ARATH / Q9SEY5 Isovalerate--CoA ligase AAE2; 3-methylpentanoate--CoA ligase AAE2; 4-methylpentanoate--CoA ligase AAE2; AMP-binding protein 2; AtAMPBP2; Acyl-activating enzyme 2; Butanoate--CoA ligase AAE2; Hexanoate--CoA ligase AAE2; Pentanoate--CoA ligase AAE2; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
603 amino acids: PaperBLAST, CDD, SwissProt::Q9SEY5
53% identical to

ACSM2_RAT / O70490 Acyl-coenzyme A synthetase ACSM2, mitochondrial; Acyl-CoA synthetase medium-chain family member 2; Benzoate--CoA ligase; Butyrate--CoA ligase 2; Butyryl-coenzyme A synthetase 2; Kidney-specific protein KS; Middle-chain acyl-CoA synthetase 2; EC 6.2.1.2; EC 6.2.1.25 from Rattus norvegicus (Rat)
PFams: AMP-binding, AMP-binding_C
572 amino acids: PaperBLAST, CDD, SwissProt::O70490
54% identical to

ACSA_MYCS2 / A0R5G1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
PFams: ACAS_N, AMP-binding, AMP-binding_C
940 amino acids: PaperBLAST, CDD, SwissProt::A0R5G1
52% identical to

P31638 acetyl-CoA synthetase (EC 6.2.1.1; EC 6.2.1.17) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
ACSA_CUPNH / P31638 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
PFams: ACAS_N, AMP-binding, AMP-binding_C
660 amino acids: PaperBLAST, CDD

ACSA_MYCTU / P9WQD1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: ACAS_N, AMP-binding, AMP-binding_C
651 amino acids: PaperBLAST, CDD, SwissProt::P9WQD1
51% identical to

J9ZU73 cinnamate:CoA ligase (EC 6.2.1.12) from Hypericum calycinum
PFams: AMP-binding, AMP-binding_C
572 amino acids: PaperBLAST, CDD, metacyc::MONOMER-17857
52% identical to

Q08AH1 medium-chain acyl-CoA synthetase ACSM1 (EC 6.2.1.2) from Homo sapiens
ACSM1_HUMAN / Q08AH1 Acyl-coenzyme A synthetase ACSM1, mitochondrial; Acyl-CoA synthetase medium-chain family member 1; Benzoate--CoA ligase; Butyrate--CoA ligase 1; Butyryl-coenzyme A synthetase 1; Lipoate-activating enzyme; Middle-chain acyl-CoA synthetase 1; Xenobiotic/medium-chain fatty acid-CoA ligase HXM-B; EC 6.2.1.2; EC 6.2.1.25 from Homo sapiens (Human)
PFams: AMP-binding, AMP-binding_C
577 amino acids: PaperBLAST, CDD, SwissProt::Q08AH1
53% identical to

ACSM1_BOVIN / Q9BEA2 Acyl-coenzyme A synthetase ACSM1, mitochondrial; Acyl-CoA synthetase medium-chain family member 1; Benzoate--CoA ligase; Butyrate--CoA ligase 1; Butyryl-coenzyme A synthetase 1; Lipoate-activating enzyme; Middle-chain acyl-CoA synthetase 1; XL-III; Xenobiotic/medium-chain fatty acid:CoA ligase XL-3; XM-ligase 3; EC 6.2.1.2; EC 6.2.1.25 from Bos taurus (Bovine)
PFams: AMP-binding, AMP-binding_C
577 amino acids: PaperBLAST, CDD, SwissProt::Q9BEA2
56% identical to

A0A144QFN1 acetate-CoA ligase (EC 6.2.1.1) from Dunaliella tertiolecta
PFams: ACAS_N, AMP-binding, AMP-binding_C
727 amino acids: PaperBLAST, CDD, BRENDA::A0A144QFN1
51% identical to

ACSA_MOUSE / Q9QXG4 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Mus musculus (Mouse)
PFams: ACAS_N, AMP-binding, AMP-binding_C
701 amino acids: PaperBLAST, CDD

M4IRL4 isovalerate--CoA ligase (EC 6.2.1.1) from Humulus lupulus
CCL2_HUMLU / M4IRL4 Isovalerate--CoA ligase CCL2; HlCCL2; 3-methylpentanoate--CoA ligase AAE2; 4-methylpentanoate--CoA ligase AAE2; Butanoate--CoA ligase CCL3; Hexanoate--CoA ligase CCL3; Pentanoate--CoA ligase CCL3; EC 6.2.1.- from Humulus lupulus (European hop)
PFams: AMP-binding, AMP-binding_C
573 amino acids: PaperBLAST, CDD, SwissProt::M4IRL4
51% identical to

CH_122470 acetyl-coenzyme A synthetase; EC 6.2.1.1 from Emericella nidulans
PFams: ACAS_N, AMP-binding, AMP-binding_C
670 amino acids: PaperBLAST, CDD, CharProtDB::CH_122470
50% identical to

ACSM1_MOUSE / Q91VA0 Acyl-coenzyme A synthetase ACSM1, mitochondrial; Acyl-CoA synthetase medium-chain family member 1; Benzoate--CoA ligase; Butyrate--CoA ligase 1; Butyryl-coenzyme A synthetase 1; Lipoate-activating enzyme; Middle-chain acyl-CoA synthetase 1; EC 6.2.1.2; EC 6.2.1.25 from Mus musculus (Mouse)
PFams: AMP-binding, AMP-binding_C
573 amino acids: PaperBLAST, CDD, SwissProt::Q91VA0
54% identical to

Q4FP19 3-(methylthio)propionyl-CoA ligase (EC 6.2.1.44) from Candidatus Pelagibacter ubique
PFams: AMP-binding, AMP-binding_C
542 amino acids: PaperBLAST, CDD, BRENDA::Q4FP19
50% identical to

Q88J54 short chain acyl-CoA synthetase (EC 6.2.1.2) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
PFams: AMP-binding, AMP-binding_C
548 amino acids: PaperBLAST, CDD, metacyc::G1G01-2975-MONOMER
49% identical to

Q2XNL6 acetate-CoA ligase (EC 6.2.1.1) from Methanothermobacter thermautotrophicus
PFams: ACAS_N, AMP-binding, AMP-binding_C
634 amino acids: PaperBLAST, CDD, BRENDA::Q2XNL6
49% identical to

I3PB36 cinnamate:CoA ligase (EC 6.2.1.12) from Petunia hybrida
CNL_PETHY / I3PB36 Trans-cinnamate:CoA ligase, peroxisomal; Cinnamic acid:CoA ligase; Ph-CNL; PhCNL; (E)-caffeate:CoA ligase CNL; 4-coumarate:CoA ligase CNL; Protein ACYL-ACTIVATING ENZYME; PhAAE; EC 6.2.1.-; EC 6.2.1.12 from Petunia hybrida (Petunia)
PFams: AMP-binding, AMP-binding_C
570 amino acids: PaperBLAST, CDD, SwissProt::I3PB36
48% identical to

Q2I0L7 acetate-CoA ligase (EC 6.2.1.1) from Methanothermobacter thermautotrophicus
PFams: ACAS_N, AMP-binding, AMP-binding_C
634 amino acids: PaperBLAST, CDD, BRENDA::Q2I0L7
48% identical to

AAE11_ARATH / Q9C8D4 Butyrate--CoA ligase AAE11, peroxisomal; Acyl-activating enzyme 11; Butyryl-CoA synthetase; EC 6.2.1.2 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
572 amino acids: PaperBLAST, CDD, SwissProt::Q9C8D4
48% identical to

CH_122700 acetyl-coenzyme A synthetase 2; EC 6.2.1.1 from Candida albicans
PFams: ACAS_N, AMP-binding, AMP-binding_C
671 amino acids: PaperBLAST, CDD, CharProtDB::CH_122700
49% identical to

P52910 acetyl CoA synthetase 2 (EC 6.2.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ACS2_YEAST / P52910 Acetyl-coenzyme A synthetase 2; Acetate--CoA ligase 2; Acyl-activating enzyme 2; EC 6.2.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P52910 acetate-CoA ligase (EC 6.2.1.1) from Saccharomyces cerevisiae
PFams: ACAS_N, AMP-binding, AMP-binding_C
683 amino acids: PaperBLAST, CDD, BRENDA::P52910
49% identical to

AAE12_ARATH / Q9SS00 Probable acyl-activating enzyme 12, peroxisomal; EC 6.2.1.- from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
578 amino acids: PaperBLAST, CDD, SwissProt::Q9SS00
46% identical to

A4YGF9 4-hydroxybutyrate-CoA ligase (AMP-forming) (EC 6.2.1.40) from Metallosphaera sedula
PFams: ACAS_N, AMP-binding, AMP-binding_C
664 amino acids: PaperBLAST, CDD, BRENDA::A4YGF9
48% identical to

Q01574 acetyl CoA synthetase 1 (EC 6.2.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ACS1_YEAST / Q01574 Acetyl-coenzyme A synthetase 1; Acetate--CoA ligase 1; Acyl-activating enzyme 1; EC 6.2.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: ACAS_N, AMP-binding, AMP-binding_C
713 amino acids: PaperBLAST, CDD, SwissProt::Q01574
47% identical to

Q9SS01 benzoate-CoA ligase (EC 6.2.1.25) from Arabidopsis thaliana
AAE20_ARATH / Q9SS01 Benzoate--CoA ligase, peroxisomal; Acyl-activating enzyme 20; Protein BENZOYLOXYGLUCOSINOLATE 1; EC 6.2.1.25 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AMP-binding, AMP-binding_C
580 amino acids: PaperBLAST, CDD, SwissProt::Q9SS01
46% identical to

ACSA_METTP / A0B8F1 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
A0B8F1 acetate-CoA ligase (EC 6.2.1.1) from Methanothrix thermoacetophila
PFams: ACAS_N, AMP-binding, AMP-binding_C
659 amino acids: PaperBLAST, CDD, BRENDA::A0B8F1
45% identical to

PYR1_ASPFU / Q4WLD5 Nicotinic acid-CoA ligase pyr1; Pyripyropene synthesis protein 1; EC 6.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
PFams: AMP-binding, AMP-binding_C
581 amino acids: PaperBLAST, CDD, SwissProt::Q4WLD5
44% identical to

PPSA_ASPOR / Q2UB01 Acyl-CoA ligase ppsA; 2,4'-dihydroxy-3'-methoxypropiophenone biosynthesis cluster protein A; EC 6.2.1.13; EC 6.2.1.17 from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
PFams: AMP-binding, AMP-binding_C
561 amino acids: PaperBLAST, CDD

OLCI_PENCN / P9WEQ8 Nicotinic acid-CoA ligase olcI; 15-deoxyoxalicine B biosynthesis cluster protein I; EC 6.2.1.- from Penicillium canescens
PFams: AMP-binding, AMP-binding_C
546 amino acids: PaperBLAST, CDD, SwissProt::P9WEQ8
44% identical to

B1YBY4 4-hydroxybutyrate-CoA ligase (AMP-forming) (EC 6.2.1.40) from Pyrobaculum neutrophilum
PFams: ACAS_N, AMP-binding, AMP-binding_C
629 amino acids: PaperBLAST, CDD, BRENDA::B1YBY4
45% identical to

Q8TLW1 medium-chain acyl-CoA ligase (EC 6.2.1.2) from Methanosarcina acetivorans
PFams: AMP-binding, AMP-binding_C
560 amino acids: PaperBLAST, CDD, BRENDA::Q8TLW1
40% identical to

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for prpE.)

ACSA_SALTY / Q8ZKF6 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: ACAS_N, AMP-binding, AMP-binding_C
652 amino acids: PaperBLAST, CDD, SwissProt::Q8ZKF6
95% identical to