Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for prpE (propionyl-CoA synthetase) in L-isoleucine biosynthesis

Or see other characterized proteins similar to prpE

Or see all steps for L-isoleucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of prpE

Curated proteins matching propionyl-CoA synthetase
Curated proteins matching propionate--CoA ligase
Curated proteins or TIGRFams with EC 6.2.1.17
Ignore hits to Q8ZKF6 when looking for 'other' hits (Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1)
Comment: Q8ZKF6 is very similar to E. coli acs and likely has this activity, so it is ignored.

Fetched 20 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 19 of these sequences

Found 2 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by cluster

Aspergillus oryzae

PPSA_ASPOR / Q2UB01 Acyl-CoA ligase ppsA; 2,4'-dihydroxy-3'-methoxypropiophenone biosynthesis cluster protein A; EC 6.2.1.13; EC 6.2.1.17 from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
PFams: AMP-binding, AMP-binding_C
561 amino acids: PaperBLAST, CDD (Singleton 1)

Cupriavidus necator

P31638 acetyl-CoA synthetase (EC 6.2.1.1; EC 6.2.1.17) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
ACSA_CUPNH / P31638 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
PFams: ACAS_N, AMP-binding, AMP-binding_C
660 amino acids: PaperBLAST, CDD (Cluster 1)

Escherichia coli

b0335 propionyl-CoA synthetase (EC 6.2.1.17) from Escherichia coli K-12 substr. MG1655
P77495 propionyl-CoA synthetase (EC 6.2.1.17) from Escherichia coli (strain K12)
P77495 propionate-CoA ligase (EC 6.2.1.17) from Escherichia coli
PFams: ACAS_N, AMP-binding, AMP-binding_C
628 amino acids: PaperBLAST, CDD (Cluster 1)

b4069 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.1; EC 6.2.1.17) from Escherichia coli K-12 substr. MG1655
P27550 acetyl-CoA synthetase (AMP-forming) (EC 6.2.1.17; EC 6.2.1.1) from Escherichia coli (strain K12)
ACSA_ECOLI / P27550 Acetyl-coenzyme A synthetase; AcCoA synthetase; Acs; Acetate--CoA ligase; Acyl-activating enzyme; EC 6.2.1.1 from Escherichia coli (strain K12)
PFams: ACAS_N, AMP-binding, AMP-binding_C
652 amino acids: PaperBLAST, CDD (Cluster 1)

Homo sapiens

Q9NR19 acetyl-coA synthetase (EC 6.2.1.1) from Homo sapiens
ACSA_HUMAN / Q9NR19 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human)
Q9NR19 acetate-CoA ligase (EC 6.2.1.1) from Homo sapiens
PFams: ACAS_N, AMP-binding, AMP-binding_C
701 amino acids: PaperBLAST, CDD (Cluster 1)

ACS2L_HUMAN / Q9NUB1 Acetyl-coenzyme A synthetase 2-like, mitochondrial; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; AceCS2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human)
Q9NUB1 acetate-CoA ligase (EC 6.2.1.1) from Homo sapiens
PFams: ACAS_N, AMP-binding, AMP-binding_C
689 amino acids: PaperBLAST, CDD (Cluster 1)

ACSM3_HUMAN / Q53FZ2 Acyl-coenzyme A synthetase ACSM3, mitochondrial; Acyl-CoA synthetase medium-chain family member 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle-chain acyl-CoA synthetase 3; Propionate--CoA ligase; Protein SA homolog; EC 6.2.1.2; EC 6.2.1.17 from Homo sapiens (Human)
PFams: AMP-binding, AMP-binding_C
586 amino acids: PaperBLAST, CDD (Cluster 1)

ACSS3_HUMAN / Q9H6R3 Acyl-CoA synthetase short-chain family member 3, mitochondrial; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Homo sapiens (Human)
PFams: ACAS_N, AMP-binding, AMP-binding_C
686 amino acids: PaperBLAST, CDD (Cluster 1)

Humulus lupulus

M4IQQ5 isobutanoate/2-methylbutanoate--CoA ligase (EC 6.2.1.1) from Humulus lupulus
CCL4_HUMLU / M4IQQ5 2-methylpropanoate--CoA ligase CCL4; HlCCL4; 2-methylbutanoate--CoA ligase CCL4; Butanoate--CoA ligase CCL3; Propionate--CoA ligase CCL3; EC 6.2.1.-; EC 6.2.1.17 from Humulus lupulus (European hop)
PFams: AMP-binding, AMP-binding_C
556 amino acids: PaperBLAST, CDD (Cluster 2)

CCL3_HUMLU / M4IS88 Acetate--CoA ligase CCL3; HlCCL3; 2-methylbutanoate--CoA ligase CCL4; 2-methylpropanoate--CoA ligase CCL4; Butanoate--CoA ligase CCL3; Hexanoate--CoA ligase CCL3; Isovalerate--CoA ligase CCL3; Pentanoate--CoA ligase CCL3; Propionate--CoA ligase CCL3; EC 6.2.1.1; EC 6.2.1.-; EC 6.2.1.17 from Humulus lupulus (European hop)
PFams: AMP-binding, AMP-binding_C
568 amino acids: PaperBLAST, CDD (Cluster 2)

Metallosphaera sedula

HBCL2_METS5 / A4YDR9 4-hydroxybutyrate--CoA ligase 2; Acetate--CoA ligase; Butyrate--CoA ligase; Propionate--CoA ligase; acyl-activating enzyme; EC 6.2.1.40; EC 6.2.1.1; EC 6.2.1.2; EC 6.2.1.17 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YDR9 4-hydroxybutyrate-CoA ligase (AMP-forming) (EC 6.2.1.40) from Metallosphaera sedula
PFams: AMP-binding, AMP-binding_C
549 amino acids: PaperBLAST, CDD (Cluster 2)

A4YDT1 4-hydroxybutyryl-CoA synthetase (AMP-forming) (EC 6.2.1.40) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
HBCL1_METS5 / A4YDT1 4-hydroxybutyrate--CoA ligase 1; Acetate--CoA ligase; Butyrate--CoA ligase; Propionate--CoA ligase; EC 6.2.1.40; EC 6.2.1.1; EC 6.2.1.2; EC 6.2.1.17 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YDT1 4-hydroxybutyrate-CoA ligase (AMP-forming) (EC 6.2.1.40) from Metallosphaera sedula
PFams: AMP-binding, AMP-binding_C
564 amino acids: PaperBLAST, CDD (Cluster 1)

A4YGR1 3-hydroxypropionyl-CoA synthetase subunit (EC 6.2.1.36) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
HPCAS_METS5 / A4YGR1 3-hydroxypropionyl-coenzyme A synthetase; 3-hydroxypropionyl-CoA synthetase; EC 6.2.1.36 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
A4YGR1 propionate-CoA ligase (EC 6.2.1.17); 3-hydroxypropionyl-CoA synthase (EC 6.2.1.36) from Metallosphaera sedula
PFams: ACAS_N, AMP-binding, AMP-binding_C
661 amino acids: PaperBLAST, CDD (Cluster 1)

Mus musculus

ACS2L_MOUSE / Q99NB1 Acetyl-coenzyme A synthetase 2-like, mitochondrial; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; AceCS2; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Mus musculus (Mouse)
Q99NB1 acetate-CoA ligase (EC 6.2.1.1) from Mus musculus
PFams: ACAS_N, AMP-binding, AMP-binding_C
682 amino acids: PaperBLAST, CDD (Cluster 1)

ACSM3_MOUSE / Q3UNX5 Acyl-coenzyme A synthetase ACSM3, mitochondrial; Acyl-CoA synthetase medium-chain family member 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle-chain acyl-CoA synthetase 3; Propionate--CoA ligase; Protein SA homolog; EC 6.2.1.2; EC 6.2.1.17 from Mus musculus (Mouse)
PFams: AMP-binding, AMP-binding_C
580 amino acids: PaperBLAST, CDD (Singleton 2)

ACSA_MOUSE / Q9QXG4 Acetyl-coenzyme A synthetase, cytoplasmic; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Mus musculus (Mouse)
PFams: ACAS_N, AMP-binding, AMP-binding_C
701 amino acids: PaperBLAST, CDD (Cluster 1)

Phaeobacter inhibens

PGA1_c11900 Propionate--CoA ligase (EC 6.2.1.17) from Phaeobacter inhibens BS107
PFams: ACAS_N, AMP-binding, AMP-binding_C
629 amino acids: PaperBLAST, CDD (Cluster 1)

Rattus norvegicus

ACSS3_RAT / A0A0G2K047 Acyl-CoA synthetase short-chain family member 3, mitochondrial; Acetate--CoA ligase 3; Acyl-CoA synthetase short-chain family member 3; Propionate--CoA ligase; EC 6.2.1.1; EC 6.2.1.17 from Rattus norvegicus (Rat)
A0A0G2K047 propionate-CoA ligase (EC 6.2.1.17) from Rattus norvegicus
PFams: ACAS_N, AMP-binding, AMP-binding_C
683 amino acids: PaperBLAST, CDD (Cluster 1)

Ruegeria pomeroyi

Q5LPB4 propionate--CoA ligase (EC 6.2.1.17) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
PFams: ACAS_N, AMP-binding, AMP-binding_C
629 amino acids: PaperBLAST, CDD (Cluster 1)

Salmonella typhimurium

P55912 propionate-CoA ligase (EC 6.2.1.17) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PRPE_SALTY / P55912 Propionate--CoA ligase; Propionyl-CoA synthetase; EC 6.2.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: ACAS_N, AMP-binding, AMP-binding_C
628 amino acids: PaperBLAST, CDD (Cluster 1)