Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for leuA (2-isopropylmalate synthase) in L-leucine biosynthesis

Or see other characterized proteins similar to leuA

Or see all steps for L-leucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of leuA

Curated proteins or TIGRFams with EC 2.3.3.13
UniProt sequence L0G5E1_ECHVK: SubName: Full=Isopropylmalate/homocitrate/citramalate synthase {ECO:0000313|EMBL:AGA80045.1};
UniProt sequence A0A1X9Z750_9SPHI: SubName: Full=2-isopropylmalate synthase {ECO:0000313|EMBL:ARS41048.1};
Ignore hits to items matching isopropylmalate synthase when looking for 'other' hits
Comment: Ignore CharProtDB entries with no EC number. Add Echvi_3833 (L0G5E1_ECHVK) and CA265_RS15855 (A0A1X9Z750_9SPHI), which are supported by fitness data

Fetched 23 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 22 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 445-631 amino acids (not heteromeric)

Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13
Q58595 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
518 amino acids: PaperBLAST, CDD, Compare to cluster

D0VY45 homocitrate synthase (EC 2.3.3.14) (from HMM only)
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD, Compare to cluster

K4C627 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
612 amino acids: PaperBLAST, CDD, Compare to cluster

K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like
445 amino acids: PaperBLAST, CDD, Compare to cluster

Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
623 amino acids: PaperBLAST, CDD, Compare to cluster

Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
631 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17
Q9FG67 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17)
PFams: HMGL-like
506 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17
Q9FN52 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17)
AT5G23020-MONOMER methylthioalkylmalate synthase
PFams: HMGL-like
503 amino acids: PaperBLAST, CDD, Compare to cluster

Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
517 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
631 amino acids: PaperBLAST, CDD, Compare to cluster

P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13
PFams: HMGL-like, LeuA_dimer
523 amino acids: PaperBLAST, CDD, Compare to cluster

2-ISOPROPYLMALATESYN-MONOMER 2-isopropylmalate synthase (EC 2.3.3.13)
2-ISOPROPYLMALATESYN-MONOMER 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
523 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 582-644 amino acids (not heteromeric)

C9K7B8 Isopropyl malate synthase AMT7; AM-toxin biosynthesis protein 7; EC 2.3.3.13
PFams: HMGL-like
582 amino acids: PaperBLAST, CDD, Compare to cluster

P9WQB3 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like, LeuA_dimer
644 amino acids: PaperBLAST, CDD, Compare to cluster

K0E4E5 Isopropyl malate synthase htyA; L-homotyrosine biosynthetic cluster protein A; EC 2.3.3.13
PFams: HMGL-like
584 amino acids: PaperBLAST, CDD, Compare to cluster

P06208 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13
PFams: HMGL-like, LeuA_dimer
619 amino acids: PaperBLAST, CDD, Compare to cluster

Q12166 2-isopropylmalate synthase 2, mitochondrial; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II; EC 2.3.3.13
PFams: HMGL-like, LeuA_dimer
604 amino acids: PaperBLAST, CDD, Compare to cluster

S3D9F8 Isopropyl malate synthase gloH; L-homotyrosine biosynthesis sub-cluster protein gloH; Pneumocandin biosynthesis cluster protein H; EC 2.3.3.13
PFams: HMGL-like
617 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 386-394 amino acids (not heteromeric)

B0SN40 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like
394 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0G2T6D7 2-isopropylmalate synthase (EC 2.3.3.13)
PFams: HMGL-like
394 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9Z750_9SPHI 2-isopropylmalate synthase
386 amino acids: PaperBLAST, CDD, Compare to cluster

L0G5E1_ECHVK Isopropylmalate/homocitrate/citramalate synthase
390 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

P85362 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13
9 amino acids: PaperBLAST, CDD