GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for leuA (2-isopropylmalate synthase) in L-leucine biosynthesis

Or see other characterized proteins similar to leuA

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Definition of leuA

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 31 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 386-635 amino acids (not heteromeric)

LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
PFams: HMGL-like, LeuA_dimer
501 amino acids: PaperBLAST, CDD, Compare to cluster

D0VY45 homocitrate synthase (EC 2.3.3.14) (from HMM only) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD, Compare to cluster

K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum
PFams: HMGL-like, LeuA_dimer
612 amino acids: PaperBLAST, CDD, Compare to cluster

K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum
PFams: HMGL-like
445 amino acids: PaperBLAST, CDD, Compare to cluster

Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group
PFams: HMGL-like, LeuA_dimer
635 amino acids: PaperBLAST, CDD, Compare to cluster

Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group
PFams: HMGL-like, LeuA_dimer
635 amino acids: PaperBLAST, CDD, Compare to cluster

Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis
PFams: HMGL-like, LeuA_dimer
623 amino acids: PaperBLAST, CDD, Compare to cluster

LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii
PFams: HMGL-like, LeuA_dimer
518 amino acids: PaperBLAST, CDD, Compare to cluster

Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus
PFams: HMGL-like, LeuA_dimer
520 amino acids: PaperBLAST, CDD, Compare to cluster

LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana
PFams: HMGL-like, LeuA_dimer
631 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FG67 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
MAM1_ARATH / Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q9FG67 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
506 amino acids: PaperBLAST, CDD, Compare to cluster

Q9FN52 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
MAM3_ARATH / Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q9FN52 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
503 amino acids: PaperBLAST, CDD, Compare to cluster

LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis
PFams: HMGL-like, LeuA_dimer
517 amino acids: PaperBLAST, CDD, Compare to cluster

LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana
PFams: HMGL-like, LeuA_dimer
631 amino acids: PaperBLAST, CDD, Compare to cluster

LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: HMGL-like, LeuA_dimer
523 amino acids: PaperBLAST, CDD, Compare to cluster

LEU1_SOYBN / Q39891 Probable 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; Late nodulin-56; N-56; EC 2.3.3.13 from Glycine max (Soybean) (Glycine hispida)
PFams: HMGL-like, LeuA_dimer
565 amino acids: PaperBLAST, CDD, Compare to cluster

LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
PFams: HMGL-like
386 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9Z750_9SPHI 2-isopropylmalate synthase
386 amino acids: PaperBLAST, CDD, Compare to cluster

L0G5E1_ECHVK Isopropylmalate/homocitrate/citramalate synthase
390 amino acids: PaperBLAST, CDD, Compare to cluster

b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655
P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12)
PFams: HMGL-like, LeuA_dimer
523 amino acids: PaperBLAST, CDD, Compare to cluster

BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
PFams: HMGL-like, LeuA_dimer
498 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_3833 2-isopropylmalate synthase (EC 2.3.3.13) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: HMGL-like
390 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS15855 2-isopropylmalate synthase (EC 2.3.3.13) from Pedobacter sp. GW460-11-11-14-LB5
PFams: HMGL-like
386 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 582-644 amino acids (not heteromeric)

LEU1_MYCTO / P9WQB2 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
LEU1_MYCTU / P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WQB3 2-isopropylmalate synthase (EC 2.3.3.13) from Mycobacterium tuberculosis
PFams: HMGL-like, LeuA_dimer
644 amino acids: PaperBLAST, CDD, Compare to cluster

AMT7_ALTAL / C9K7B8 Isopropyl malate synthase AMT7; AM-toxin biosynthesis protein 7; EC 2.3.3.13 from Alternaria alternata (Alternaria rot fungus) (Torula alternata)
PFams: HMGL-like
582 amino acids: PaperBLAST, CDD, Compare to cluster

LEU1_YEAST / P06208 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: HMGL-like, LeuA_dimer
619 amino acids: PaperBLAST, CDD, Compare to cluster

LEU1_CORGL / P42455 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: HMGL-like, LeuA_dimer
616 amino acids: PaperBLAST, CDD, Compare to cluster

LEU9_YEAST / Q12166 2-isopropylmalate synthase 2, mitochondrial; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II; EC 2.3.3.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: HMGL-like, LeuA_dimer
604 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 394-428 amino acids (not heteromeric)

B0SN40 2-isopropylmalate synthase (EC 2.3.3.13) from Leptospira biflexa
PFams: HMGL-like
394 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0G2T6D7 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum pennellii
PFams: HMGL-like
394 amino acids: PaperBLAST, CDD, Compare to cluster

LEU12_LEPIN / Q8F8T4 2-isopropylmalate synthase 2; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
PFams: HMGL-like
428 amino acids: PaperBLAST, CDD, Compare to cluster