Clusters of Characterized Proteins

Clustering the characterized proteins for leuD (3-isopropylmalate dehydaratase, small subunit) in L-leucine biosynthesis

Or see other characterized proteins similar to leuD

Or see all steps for L-leucine biosynthesis

Or cluster curated proteins matching a keyword

Definition of leuD

• Curated proteins matching 3-isopropylmalate dehydratase small subunit
• Curated proteins matching 3-isopropylmalate dehydratase%LeuD
• HMM TIGR00171
• HMM TIGR02084
• HMM TIGR02087
• Ignore hits to Q0QLE1 when looking for 'other' hits (2,3-dimethylmalate dehydratase small subunit; EC 4.2.1.85)
• Ignore hits to items matching EC 4.2.1.33 when looking for 'other' hits
• Ignore hits to items matching EC 4.2.1.35 when looking for 'other' hits
• UniProt sequence LEUD_DESVH: RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000255|HAMAP-Rule:MF_01032}; EC=4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01032}; AltName: Full=Alpha-IPM isomerase {ECO:0000255|HAMAP-Rule:MF_01032}; Short=IPMI {ECO:0000255|HAMAP-Rule:MF_01032}; AltName: Full=Isopropylmalate isomerase {ECO:0000255|HAMAP-Rule:MF_01032};
• Ignore hits to CH_122621 when looking for 'other' hits (alpha isopropylmalate isomerase (Eurofung))
• Comment: DvH leuD (DVU2983) has similarity to both LeuD and to homoaconitase, and fitness data confirms its role in amino acid biosynthesis.

Fetched 13 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 13 of these sequences

Found 4 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 197-201 amino acids (heteromeric)

P65278 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33
P9WK95 3-isopropylmalate dehydratase (EC 4.2.1.33)
PFams: Aconitase_C
Heteromeric, 198 amino acids: PaperBLAST, CDD, Compare to cluster

P04787 3-isopropylmalate dehydratase small subunit 1; Alpha-IPM isomerase 1; IPMI 1; Isopropylmalate isomerase 1; EC 4.2.1.33
PFams: Aconitase_C
Heteromeric, 201 amino acids: PaperBLAST, CDD, Compare to cluster

Q8NQV7 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33
PFams: Aconitase_C
Heteromeric, 197 amino acids: PaperBLAST, CDD, Compare to cluster

LEUD-MONOMER 3-isopropylmalate dehydratase subunit LeuD (EC 4.2.1.33)
LEUD-MONOMER LeuD
PFams: Aconitase_C
Heteromeric, 201 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 251-256 amino acids (heteromeric)

Q9LYT7 3-isopropylmalate dehydratase small subunit 2; AtLEUD2; Isopropylmalate isomerase small subunit 1; EC 4.2.1.33
Q9LYT7 2-(omega-methylthio)alkylmalate dehydratase (subunit 1/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33)
PFams: Aconitase_C
Heteromeric, 253 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZW84 3-isopropylmalate dehydratase small subunit 1; AtLEUD1; Isopropylmalate isomerase small subunit 2; EC 4.2.1.33
Q9ZW84 3-isopropylmalate dehydratase (EC 4.2.1.33)
PFams: Aconitase_C
Heteromeric, 256 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZW85 3-isopropylmalate dehydratase small subunit 3; AtLEUD3; Isopropylmalate isomerase small subunit 3; EC 4.2.1.33
Q9ZW85 2-(omega-methylthio)alkylmalate dehydratase (subunit 1/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33)
PFams: Aconitase_C
Heteromeric, 251 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 163-170 amino acids (2/3 heteromeric)

Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 (from HMM only)
PFams: Aconitase_2_N, Aconitase_C
Heteromeric, 170 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZND9 Homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.36 (from HMM only)
PFams: Aconitase_C
Heteromeric, 163 amino acids: PaperBLAST, CDD, Compare to cluster

LEUD_DESVH 3-isopropylmalate dehydratase small subunit {ECO:0000255|HAMAP-Rule:MF_01032}; EC=4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01032}; Alpha-IPM isomerase {ECO:0000255|HAMAP-Rule:MF_01032}; Short=IPMI {ECO:0000255|HAMAP-Rule:MF_01032}; AltName: Full=Isopropylmalate isomerase {ECO:0000255|HAMAP-Rule:MF_01032}
167 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 811-843 amino acids (not heteromeric)

C9K7B9 Aconitase AMT8; AM-toxin biosynthesis protein 8; EC 4.2.1.- (from HMM only)
PFams: Aconitase, Aconitase, Aconitase_C
840 amino acids: PaperBLAST, CDD, Compare to cluster

C9K7I3 Aconitase AMT8-2; AM-toxin biosynthesis protein 8-2; EC 4.2.1.- (from HMM only)
PFams: Aconitase, Aconitase, Aconitase_C
843 amino acids: PaperBLAST, CDD, Compare to cluster

Q4WBR0 Putative aconitate hydratase; Aconitase 3; EC 4.2.1.- (from HMM only)
PFams: Aconitase, Aconitase_C
811 amino acids: PaperBLAST, CDD, Compare to cluster