GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for asp-kinase (aspartate kinase) in L-lysine biosynthesis

Or see other characterized proteins similar to asp-kinase

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of asp-kinase

Fetched 36 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 33 of these sequences

Found 3 clusters of similar sequences. Another 4 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 404-600 amino acids (2/22 heteromeric)

Q57991 aspartate kinase (EC 2.7.2.4) from Methanocaldococcus jannaschii
PFams: AA_kinase, ACT_7, ACT, ACT_7, ACT
473 amino acids: PaperBLAST, CDD, Compare to cluster

AK2_ARATH / O23653 Aspartokinase 2, chloroplastic; Aspartate kinase 2; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress)
O23653 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana
PFams: AA_kinase
544 amino acids: PaperBLAST, CDD, Compare to cluster

O69077 aspartate kinase (EC 2.7.2.4) from Pseudomonas aeruginosa
PFams: AA_kinase, ACT, ACT_7
412 amino acids: PaperBLAST, CDD, Compare to cluster

P08495 aspartate kinase II α subunit (EC 2.7.2.4) from Bacillus subtilis (strain 168)
P08495 aspartate kinase II β subunit (EC 2.7.2.4) from Bacillus subtilis (strain 168)
AK2_BACSU / P08495 Aspartokinase 2; Aspartate kinase 2; Aspartokinase II; EC 2.7.2.4 from Bacillus subtilis (strain 168)
P08495 aspartate kinase (EC 2.7.2.4) from Bacillus subtilis
GB|CAA99580.1 aspartate kinase 2; EC 2.7.2.4 from Bacillus subtilis
PFams: AA_kinase, ACT, ACT_7
Heteromeric, 408 amino acids: PaperBLAST, CDD, Compare to cluster

b4024 aspartate kinase III (EC 2.7.2.4) from Escherichia coli K-12 substr. MG1655
P08660 aspartate kinase III (EC 2.7.2.4) from Escherichia coli (strain K12)
AK3_ECOLI / P08660 Lysine-sensitive aspartokinase 3; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III; EC 2.7.2.4 from Escherichia coli (strain K12)
P08660 aspartate kinase (EC 2.7.2.4) from Escherichia coli
PFams: AA_kinase
449 amino acids: PaperBLAST, CDD, Compare to cluster

AK_YEAST / P10869 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P10869 aspartate kinase (EC 2.7.2.4) from Saccharomyces cerevisiae
PFams: AA_kinase, ACT_7
527 amino acids: PaperBLAST, CDD, Compare to cluster

P26512 aspartokinase α subunit (EC 2.7.2.4) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
P26512 aspartokinase β subunit (EC 2.7.2.4) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
AK_CORGL / P26512 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
P26512 aspartate kinase (EC 2.7.2.4) from Corynebacterium glutamicum
CH_091815 aspartate kinase 2; EC 2.7.2.4 from Corynebacterium glutamicum
PFams: AA_kinase, ACT, ACT_7
Heteromeric, 421 amino acids: PaperBLAST, CDD, Compare to cluster

P74569 aspartate kinase (EC 2.7.2.4) from Synechocystis sp.
PFams: AA_kinase, ACT, ACT_7, ACT, ACT_7
600 amino acids: PaperBLAST, CDD, Compare to cluster

AK_MYCTU / P9WPX3 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WPX3 aspartate kinase (EC 2.7.2.4) from Mycobacterium tuberculosis
PFams: AA_kinase, ACT, ACT_7
421 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JK18 aspartate kinase (EC 2.7.2.4) from Oryza sativa Japonica Group
PFams: AA_kinase
570 amino acids: PaperBLAST, CDD, Compare to cluster

Q97MC0 aspartate kinase (EC 2.7.2.4) from Clostridium acetobutylicum
PFams: AA_kinase, ACT
437 amino acids: PaperBLAST, CDD, Compare to cluster

AK1_ARATH / Q9LYU8 Aspartokinase 1, chloroplastic; Aspartate kinase 1; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress)
Q9LYU8 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana
PFams: AA_kinase
569 amino acids: PaperBLAST, CDD, Compare to cluster

Q9RUL9 aspartate kinase (EC 2.7.2.4) from Deinococcus radiodurans
PFams: AA_kinase, ACT_7, ACT_7
473 amino acids: PaperBLAST, CDD, Compare to cluster

Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana
AK3_ARATH / Q9S702 Aspartokinase 3, chloroplastic; Aspartate kinase 3; EC 2.7.2.4 from Arabidopsis thaliana (Mouse-ear cress)
Q9S702 aspartate kinase (EC 2.7.2.4) from Arabidopsis thaliana
PFams: AA_kinase
559 amino acids: PaperBLAST, CDD, Compare to cluster

CH_090816 aspartate kinase 1; EC 2.7.2.4 from Bacillus subtilis
PFams: AA_kinase, ACT_7
404 amino acids: PaperBLAST, CDD, Compare to cluster

AKLYS_STUS1 / A4VJB4 Aspartate kinase Ask_LysC; Aspartokinase; EC 2.7.2.4 from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri)
PFams: AA_kinase, ACT, ACT_7
412 amino acids: PaperBLAST, CDD, Compare to cluster

AK_PSEFS / C3JXY0 Aspartate kinase; Aspartokinase; EC 2.7.2.4 from Pseudomonas fluorescens (strain SBW25)
PFams: AA_kinase, ACT, ACT_7
413 amino acids: PaperBLAST, CDD, Compare to cluster

AK_CORFL / P41398 Aspartokinase; Aspartate kinase; EC 2.7.2.4 from Corynebacterium flavescens
GB|AAA23293.1 aspartate kinase; EC 2.7.2.4 from Corynebacterium flavescens
PFams: AA_kinase, ACT, ACT_7
421 amino acids: PaperBLAST, CDD, Compare to cluster

AK_THET2 / P61488 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
PFams: AA_kinase, ACT, ACT_7
405 amino acids: PaperBLAST, CDD, Compare to cluster

AK_THETH / P61489 Aspartokinase; Aspartate kinase; AK; ASK; Threonine-sensitive AK; ThrA; EC 2.7.2.4 from Thermus thermophilus
P61489 aspartate kinase (EC 2.7.2.4) from Thermus thermophilus
PFams: AA_kinase, ACT, ACT_7
405 amino acids: PaperBLAST, CDD, Compare to cluster

AK_PSEPK / Q88EI9 Aspartate kinase; Aspartokinase; EC 2.7.2.4 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
PFams: AA_kinase, ACT, ACT_7
411 amino acids: PaperBLAST, CDD, Compare to cluster

Q04795 aspartokinase I (alpha and beta subunits) (EC 2.7.2.4) from Bacillus subtilis (strain 168)
PFams: AA_kinase, ACT_7
404 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 810-916 amino acids (not heteromeric)

b0002 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655
P00561 fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12)
P00561 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Escherichia coli
PFams: AA_kinase, ACT_7, ACT_7, NAD_binding_3, Homoserine_dh
820 amino acids: PaperBLAST, CDD, Compare to cluster

AKH2_ARATH / O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD, Compare to cluster

AKH1_ARATH / Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
911 amino acids: PaperBLAST, CDD, Compare to cluster

b3940 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli K-12 substr. MG1655
P00562 fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3) from Escherichia coli (strain K12)
PFams: AA_kinase, NAD_binding_3, Homoserine_dh
810 amino acids: PaperBLAST, CDD, Compare to cluster

BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Bacteroides thetaiotaomicron VPI-5482
PFams: AA_kinase, ACT_7, ACT_7, NAD_binding_3, Homoserine_dh
811 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_2000 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: AA_kinase, ACT_7, NAD_binding_3, Homoserine_dh
815 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS23475 aspartate kinase; homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) from Pedobacter sp. GW460-11-11-14-LB5
PFams: AA_kinase, ACT_7, ACT, NAD_binding_3, Homoserine_dh
817 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 510-542 amino acids (not heteromeric)

FUB3_FUSO4 / A0A0D2YG09 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato)
PFams: YCII, AA_kinase, ACT_7
542 amino acids: PaperBLAST, CDD, Compare to cluster

FUB3_GIBF5 / S0DVT6 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
PFams: AA_kinase, ACT_7
510 amino acids: PaperBLAST, CDD, Compare to cluster

FUB3_GIBM7 / W7MS01 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4 from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides)
PFams: AA_kinase, ACT_7
510 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/4 heteromeric)

Q9WZ17 homoserine dehydrogenase (EC 1.1.1.3); aspartate kinase (EC 2.7.2.4) from Thermotoga maritima
PFams: NAD_binding_3, Homoserine_dh, AA_kinase, ACT, ACT_7
739 amino acids: PaperBLAST, CDD

AKECT_STUS1 / A4VFY3 Aspartate kinase Ask_Ect; Aspartokinase; EC 2.7.2.4 from Stutzerimonas stutzeri (strain A1501) (Pseudomonas stutzeri)
PFams: AA_kinase, ACT_7, ACT
476 amino acids: PaperBLAST, CDD

P94417 aspartate kinase III (EC 2.7.2.4) from Bacillus subtilis (strain 168)
AK3_BACSU / P94417 Aspartokinase 3; Aspartate kinase 3; Aspartokinase III; EC 2.7.2.4 from Bacillus subtilis (strain 168)
PFams: AA_kinase, ACT_7
454 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q5JK18 from Cluster 1, but similarity to seed sequence is below thresholds)

N515DRAFT_4002 aspartate kinase / diaminopimelate decarboxylase (EC 4.1.1.20; EC 2.7.2.4) from Dyella japonica UNC79MFTsu3.2
PFams: AA_kinase, Orn_Arg_deC_N, Orn_DAP_Arg_deC
853 amino acids: PaperBLAST, CDD