Other Characterized Proteins Similar to dapA
Finding the characterized proteins for dapA (4-hydroxy-tetrahydrodipicolinate synthase) in L-lysine biosynthesis
Or see clustering for step dapA
Or see all steps for L-lysine biosynthesis
Or cluster curated proteins matching a keyword
Definition of dapA
- Curated proteins or TIGRFams with EC 4.3.3.7
- Curated proteins or TIGRFams with EC 4.2.1.52
- Ignore hits to Q3MFY8 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Ignore hits to Q3M723 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8))
- Ignore hits to A9CGZ4 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Ignore hits to A9CHR2 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Ignore hits to A9CL94 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Ignore hits to A9CL97 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Ignore hits to Q7D0E8 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Ignore hits to Q7D313 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Ignore hits to Q8A3Z0 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7))
- Comment: Q3MFY8, Q3M723, and many proteins form Agrobacterium tumefaciens are misannotated in BRENDA, and are ignored. (The reference for those points at gene 1133062 = Atu1024 as the synthase instead, and states that the other Agrobacterium dapA-like proteins lack this activity, see PMID:24677246.) Q8A3Z0 is annotated as this in BRENDA, but the cited paper does not demonstrate this activity, and another protein (BT0895) appears to be the major dapA in Bacteroides thetaiotaomicron, (it is essentail), so Q8A3Z0 is ignored.
Fetched 23 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 1 other characterized sequences. (Found 24 hits including self hits.)
Removing ignored items reduces this to 0 close sequences.
Close but ignored sequences
(Sequences that are similar to these will still be high-confidence candidates for dapA.)
Q3M723 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) from Trichormus variabilis
PFams: DHDPS
294 amino acids: PaperBLAST, CDD, BRENDA::Q3M723
50% identical to
Q04796 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) from Bacillus subtilis (strain 168)
PFams: DHDPS
290 amino acids: PaperBLAST, CDD