Other Characterized Proteins Similar to dapB

Finding the characterized proteins for dapB (4-hydroxy-tetrahydrodipicolinate reductase) in L-lysine biosynthesis

Or see clustering for step dapB

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of dapB

• Curated proteins or TIGRFams with EC 1.17.1.8
• UniProt sequence L0G028_ECHVK: SubName: Full=Dihydrodipicolinate reductase {ECO:0000313|EMBL:AGA78643.1};
• UniProt sequence A0A1X9Z7Q6_9SPHI: RecName: Full=4-hydroxy-tetrahydrodipicolinate reductase {ECO:0000256|HAMAP-Rule:MF_00102}; Short=HTPA reductase {ECO:0000256|HAMAP-Rule:MF_00102}; EC=1.17.1.8 {ECO:0000256|HAMAP-Rule:MF_00102};
• Curated sequence Q3MFY8: 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)
• Ignore hits to Q3M723 when looking for 'other' hits (4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8))
• Comment: Formerly known as dihydrodipicolinate reductase. Echvi_2395 (L0G028_ECHVK) and CA265_RS15670 (A0A1X9Z7Q6_9SPHI) are somewhat diverged, but conserved essentiality confirms they are dapB. Q3MFY8 is misannotated in BRENDA, so it is added manually. Q3M723 is misannotated in BRENDA, so it is ignored.

Fetched 19 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 0 other characterized sequences. (Found 17 hits including self hits.)

There are also 1 HMM-only high-coverage hits.

HMM-only sequences

(Since these sequences' annotations are outside the definition for dapB, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

DAPB3_ARATH / Q9FJ82 Dihydrodipicolinate reductase-like protein CRR1, chloroplastic; 4-hydroxy-tetrahydrodipicolinate reductase 3; HTPA reductase 3; Protein CHLORORESPIRATORY REDUCTION 1 from Arabidopsis thaliana (Mouse-ear cress)
PFams: DapB_N, DapB_C
298 amino acids: PaperBLAST, CDD