Other Characterized Proteins Similar to dapC

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to dapC

Finding the characterized proteins for dapC (N-succinyldiaminopimelate aminotransferase) in L-lysine biosynthesis

Or see clustering for step dapC

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of dapC

Curated proteins or TIGRFams with EC 2.6.1.17
Curated proteins or TIGRFams with EC 2.6.1.52
Ignore hits to O50434 when looking for 'other' hits (Probable aminotransferase Rv1178; EC 2.6.1.-)
Ignore hits to items matching EC 2.6.1.81 when looking for 'other' hits
Comment: 2.6.1.52 is the EC number for 3-phosphoserine aminotransferase (serC), which catalyzes this reaction in E. coli. The function of O50434 is not known, so similarity to it is ignored. E.coli's succinylornithine transaminase has this activity as well (PMID:25243376), so similarity to succinylornithine transaminases (EC 2.6.1.81) is ignored.

Fetched 26 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 17 other characterized sequences. (Found 43 hits including self hits.)

Removing ignored items reduces this to 8 close sequences.

There are also 1 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for dapC.)

P73133 bifunctional acetylornithine transaminase/4-aminobutyrate—2-oxoglutarate transaminase (EC 2.6.1.19; EC 2.6.1.11) from Synechocystis sp. (strain PCC 6803 / Kazusa)
P73133 acetylornithine transaminase (EC 2.6.1.11); 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Synechococcus sp. PCC 6803
PFams: Aminotran_3
429 amino acids: PaperBLAST, CDD, BRENDA::P73133
44% identical to

AZOBR_RS19025 acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] from Azospirillum brasilense Sp245
PFams: Aminotran_3
389 amino acids: PaperBLAST, CDD

A0A3Q7IS73 2-oxo-4-methylthiobutanoate-glutamine aminotransferase monomer (EC 2.6.1.117) from Solanum lycopersicum
PFams: Aminotran_1_2, Aminotran_5, DegT_DnrJ_EryC1, Cys_Met_Meta_PP
452 amino acids: PaperBLAST, CDD, metacyc::MONOMER-18739
44% identical to

DAPC_MYCTU / P9WPZ5 Probable N-succinyldiaminopimelate aminotransferase DapC; DAP-AT; EC 2.6.1.17 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WPZ5 succinyldiaminopimelate transaminase (EC 2.6.1.17) from Mycobacterium tuberculosis
PFams: Aminotran_1_2, Aminotran_5
397 amino acids: PaperBLAST, CDD

A0A1D6I5Q5 L-glutamine-4-(methylsulfanyl)-2-oxobutanoate aminotransferase (EC 2.6.1.117) from Zea mays
PFams: Aminotran_1_2, Aminotran_5, DegT_DnrJ_EryC1, Cys_Met_Meta_PP
512 amino acids: PaperBLAST, CDD, BRENDA::A0A1D6I5Q5
43% identical to

SAT_THEMA / Q9X1C0 Serine-pyruvate aminotransferase; SAT; EC 2.6.1.51 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: Aminotran_5, Aminotran_1_2, Cys_Met_Meta_PP, DegT_DnrJ_EryC1
384 amino acids: PaperBLAST, CDD, SwissProt::Q9X1C0
43% identical to

P74281 serine—glyoxylate transaminase (EC 2.6.1.52) from Synechocystis sp. (strain PCC 6803 / Kazusa)
P74281 phosphoserine transaminase (EC 2.6.1.52) from Synechocystis sp.
PFams: Aminotran_5
384 amino acids: PaperBLAST, CDD

B1XNF8 acetylornithine transaminase (EC 2.6.1.11); 4-aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) from Synechococcus sp. PCC 7002
PFams: Aminotran_3
418 amino acids: PaperBLAST, CDD, BRENDA::B1XNF8
43% identical to

AZOBR_RS19025 acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] from Azospirillum brasilense Sp245
PFams: Aminotran_3
389 amino acids: PaperBLAST, CDD

ARGD_ARATH / Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Aminotran_3
457 amino acids: PaperBLAST, CDD, SwissProt::Q9M8M7
43% identical to

AZOBR_RS19025 acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17] from Azospirillum brasilense Sp245
PFams: Aminotran_3
389 amino acids: PaperBLAST, CDD

A8J933 acetylornithine transaminase (EC 2.6.1.11) from Chlamydomonas reinhardtii
PFams: Aminotran_3
460 amino acids: PaperBLAST, CDD, BRENDA::A8J933
41% identical to

b3359 N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (EC 2.6.1.11; EC 2.6.1.17) from Escherichia coli K-12 substr. MG1655
P18335 N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (EC 2.6.1.11; EC 2.6.1.17) from Escherichia coli (strain K12)
ARGD_ECOLI / P18335 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Escherichia coli (strain K12)
PFams: Aminotran_3, Aminotran_1_2
406 amino acids: PaperBLAST, CDD

Q93R93 L-2-aminoadipate semialdehyde transaminase monomer (EC 2.6.1.118) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
LYSJ_THET2 / Q93R93 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Q93R93 [amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase (EC 2.6.1.118) from Thermus thermophilus
PFams: Aminotran_3
395 amino acids: PaperBLAST, CDD, BRENDA::Q93R93
41% identical to

ARGD_SALTY / P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Aminotran_3, Aminotran_1_2
405 amino acids: PaperBLAST, CDD

HMM-only sequences

(Since these sequences' annotations are outside the definition for dapC, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

L8EVF8 4-dedimethylamino-4-oxo-anhydrotetracycline transaminase from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234)
OXYQ_STRRM / Q3S8P9 4-dedimethylamino-4-oxo-anhydrotetracycline transaminase OxyQ; PLP-dependent aminotransferase OxyQ; Reductive transaminase oxyQ; EC 2.6.1.- from Streptomyces rimosus
PFams: Aminotran_1_2
359 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for dapC.)

O30508 succinylornithine transaminase subunit (EC 2.6.1.13; EC 2.6.1.11; EC 2.6.1.81) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
ARUC_PSEAE / O30508 Succinylornithine transaminase/acetylornithine aminotransferase; ACOAT; SOAT; Succinylornithine aminotransferase; EC 2.6.1.11; EC 2.6.1.81 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
O30508 succinylornithine transaminase (EC 2.6.1.81) from Pseudomonas aeruginosa
PFams: Aminotran_3, Aminotran_1_2
406 amino acids: PaperBLAST, CDD, BRENDA::O30508
66% identical to

Pf1N1B4_3440 Succinylornithine transaminase (EC 2.6.1.81) from Pseudomonas fluorescens FW300-N1B4
PFams: Aminotran_3
406 amino acids: PaperBLAST, CDD, reanno::pseudo1_N1B4:Pf1N1B4_3440
64% identical to

PS417_21710 Succinylornithine transaminase (EC 2.6.1.81) from Pseudomonas simiae WCS417
PFams: Aminotran_3
406 amino acids: PaperBLAST, CDD, reanno::WCS417:GFF4238
64% identical to

Y1178_MYCTU / O50434 Probable aminotransferase Rv1178; EC 2.6.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Aminotran_1_2
418 amino acids: PaperBLAST, CDD, SwissProt::O50434
62% identical to

Q82IK5 succinyldiaminopimelate transaminase (EC 2.6.1.17); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Streptomyces avermitilis
PFams: Aminotran_1_2
364 amino acids: PaperBLAST, CDD

ASTC_SALTY / Q8ZPV2 Succinylornithine transaminase; SOAT; Succinylornithine aminotransferase; EC 2.6.1.81 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Aminotran_3, Aminotran_1_2
408 amino acids: PaperBLAST, CDD, SwissProt::Q8ZPV2
62% identical to

b1748 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli K-12 substr. MG1655
P77581 succinylornithine transaminase (EC 2.6.1.81; EC 2.6.1.11) from Escherichia coli (strain K12)
ASTC_ECOLI / P77581 Succinylornithine transaminase; SOAT; Carbon starvation protein C; Succinylornithine aminotransferase; EC 2.6.1.81 from Escherichia coli (strain K12)
RF|NP_416262.1 succinylornithine transaminase; EC 2.6.1.81 from Escherichia coli K12
PFams: Aminotran_3, Aminotran_1_2
406 amino acids: PaperBLAST, CDD, CharProtDB::CH_002469
61% identical to

A0A140N9B6 succinylornithine transaminase (EC 2.6.1.81) from Escherichia coli
PFams: Aminotran_3, Aminotran_1_2
406 amino acids: PaperBLAST, CDD, BRENDA::A0A140N9B6
61% identical to

BWI76_RS11670 Succinylornithine transaminase (EC 2.6.1.81) from Klebsiella michiganensis M5al
PFams: Aminotran_3
406 amino acids: PaperBLAST, CDD, reanno::Koxy:BWI76_RS11670
60% identical to

HP15_3042 acetylornithine aminotransferase (EC 2.6.1.11); succinylornithine aminotransferase (EC 2.6.1.81) from Marinobacter adhaerens HP15
PFams: Aminotran_3
404 amino acids: PaperBLAST, CDD, reanno::Marino:GFF3099
59% identical to