Finding the characterized proteins for hcs (homocitrate synthase) in L-lysine biosynthesis
Or see clustering for step hcs
Or see all steps for L-lysine biosynthesis
Or cluster curated proteins matching a keyword
Definition of hcs
Fetched 14 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 24 other characterized sequences. (Found 38 hits including self hits.)
(Sequences that are similar to these will not be high-confidence candidates for hcs.)
LEU1_SOYBN / Q39891 Probable 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; Late nodulin-56; N-56; EC 2.3.3.13 from Glycine max (Soybean) (Glycine hispida)
PFams: HMGL-like, LeuA_dimer
565 amino acids: PaperBLAST, CDD, SwissProt::Q39891
72% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
Q30DX9 2-isopropylmalate synthase (EC 2.3.3.13) from Brassica insularis
PFams: HMGL-like, LeuA_dimer
623 amino acids: PaperBLAST, CDD, BRENDA::Q30DX9
69% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
LEU12_ARATH / Q9C550 2-isopropylmalate synthase 2, chloroplastic; 2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress)
Q9C550 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana
PFams: HMGL-like, LeuA_dimer
631 amino acids: PaperBLAST, CDD, BRENDA::Q9C550
69% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
LEU11_ARATH / Q9LPR4 2-isopropylmalate synthase 1, chloroplastic; Methylthioalkylmalate synthase-like 4; EC 2.3.3.13 from Arabidopsis thaliana (Mouse-ear cress)
Q9LPR4 2-isopropylmalate synthase (EC 2.3.3.13) from Arabidopsis thaliana
PFams: HMGL-like, LeuA_dimer
631 amino acids: PaperBLAST, CDD, BRENDA::Q9LPR4
68% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
K4C627 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum
PFams: HMGL-like, LeuA_dimer
612 amino acids: PaperBLAST, CDD, BRENDA::K4C627
66% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
Q2RAP8 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group
PFams: HMGL-like, LeuA_dimer
635 amino acids: PaperBLAST, CDD, BRENDA::Q2RAP8
64% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
Q2QXY9 2-isopropylmalate synthase (EC 2.3.3.13) from Oryza sativa Japonica Group
PFams: HMGL-like, LeuA_dimer
635 amino acids: PaperBLAST, CDD, BRENDA::Q2QXY9
64% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
LEU1_METJA / Q58595 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58595 2-isopropylmalate synthase (EC 2.3.3.13) from Methanocaldococcus jannaschii
PFams: HMGL-like, LeuA_dimer
518 amino acids: PaperBLAST, CDD, BRENDA::Q58595
51% identical to
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: HMGL-like
406 amino acids: PaperBLAST, CDD
Q58787 (R)-citratemalate synthase subunit (EC 2.3.3.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
CIMA_METJA / Q58787 (R)-citramalate synthase CimA; EC 2.3.3.21 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58787 (R)-citramalate synthase (EC 2.3.3.21) from Methanocaldococcus jannaschii
PFams: HMGL-like, LeuA_dimer
491 amino acids: PaperBLAST, CDD, BRENDA::Q58787
52% identical to
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: HMGL-like
406 amino acids: PaperBLAST, CDD
Q9FG67 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
MAM1_ARATH / Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q9FG67 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
506 amino acids: PaperBLAST, CDD, BRENDA::Q9FG67
60% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
Q9FN52 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
MAM3_ARATH / Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q9FN52 2-isopropylmalate synthase (EC 2.3.3.13); methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
503 amino acids: PaperBLAST, CDD, BRENDA::Q9FN52
60% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
LEU1_NEIMB / Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58)
Q9JZG1 2-isopropylmalate synthase (EC 2.3.3.13) from Neisseria meningitidis
PFams: HMGL-like, LeuA_dimer
517 amino acids: PaperBLAST, CDD, BRENDA::Q9JZG1
48% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus (strain ATCC 31215)
FRBC_STRR3 / Q0ZQ46 2-phosphonomethylmalate synthase; EC 2.3.3.19 from Streptomyces rubellomurinus (strain ATCC 31215)
Q0ZQ46 2-phosphonomethylmalate synthase (EC 2.3.3.19) from Streptomyces rubellomurinus
PFams: HMGL-like
373 amino acids: PaperBLAST, CDD, SwissProt::Q0ZQ46
46% identical to
P58637 homocitrate synthase (EC 2.3.3.14) from Nostoc sp. PCC 7120 = FACHB-418
PFams: HMGL-like
376 amino acids: PaperBLAST, CDD
MAM2_ARATH / Q8VX04 Methylthioalkylmalate synthase 2, chloroplastic; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress)
Q8VX04 methylthioalkylmalate synthase (EC 2.3.3.17) from Arabidopsis thaliana
PFams: HMGL-like
506 amino acids: PaperBLAST, CDD, SwissProt::Q8VX04
58% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
K4CJ56 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum lycopersicum
PFams: HMGL-like
445 amino acids: PaperBLAST, CDD, BRENDA::K4CJ56
60% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
LEU11_LEPIN / Q8F445 2-isopropylmalate synthase 1; Alpha-IPM synthase 1; Alpha-isopropylmalate synthase 1; EC 2.3.3.13 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
PFams: HMGL-like, LeuA_dimer
501 amino acids: PaperBLAST, CDD, SwissProt::Q8F445
46% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
LEU1_SULAC / Q4JA78 2-isopropylmalate synthase; IPMS; Alpha-isopropylmalate synthase; Alpha-IPM synthase; EC 2.3.3.13 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
PFams: HMGL-like
386 amino acids: PaperBLAST, CDD, SwissProt::Q4JA78
46% identical to
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: HMGL-like
406 amino acids: PaperBLAST, CDD
Q72JC9 2-isopropylmalate synthase (EC 2.3.3.13) from Thermus thermophilus
PFams: HMGL-like, LeuA_dimer
520 amino acids: PaperBLAST, CDD, BRENDA::Q72JC9
44% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
BT1861 2-isopropylmalate synthase (EC 2.3.3.13) from Bacteroides thetaiotaomicron VPI-5482
PFams: HMGL-like, LeuA_dimer
498 amino acids: PaperBLAST, CDD, reanno::Btheta:351389
44% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
b0074 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli K-12 substr. MG1655
P09151 2-isopropylmalate synthase (EC 2.3.3.13) from Escherichia coli (strain K12)
PFams: HMGL-like, LeuA_dimer
523 amino acids: PaperBLAST, CDD, ecocyc::2-ISOPROPYLMALATESYN-MONOMER
42% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
LEU1_SALTY / P15875 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: HMGL-like, LeuA_dimer
523 amino acids: PaperBLAST, CDD, SwissProt::P15875
41% identical to
D0VY45 homocitrate synthase (EC 2.3.3.14) from Lotus japonicus
PFams: HMGL-like, LeuA_dimer
540 amino acids: PaperBLAST, CDD
Echvi_3833 2-isopropylmalate synthase (EC 2.3.3.13) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: HMGL-like
390 amino acids: PaperBLAST, CDD, reanno::Cola:Echvi_3833
41% identical to
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: HMGL-like
406 amino acids: PaperBLAST, CDD
CA265_RS15855 2-isopropylmalate synthase (EC 2.3.3.13) from Pedobacter sp. GW460-11-11-14-LB5
PFams: HMGL-like
386 amino acids: PaperBLAST, CDD, reanno::Pedo557:CA265_RS15855
40% identical to
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: HMGL-like
406 amino acids: PaperBLAST, CDD
A0A0G2T6D7 2-isopropylmalate synthase (EC 2.3.3.13) from Solanum pennellii
PFams: HMGL-like
394 amino acids: PaperBLAST, CDD, BRENDA::A0A0G2T6D7
41% identical to
AKSA_METJA / Q57926 Homocitrate synthase AksA; (R)-homo(2)citrate synthase; (R)-homo(3)citrate synthase; EC 2.3.3.14; EC 2.3.3.- from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: HMGL-like
406 amino acids: PaperBLAST, CDD