Other Characterized Proteins Similar to hicdh

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to hicdh

Finding the characterized proteins for hicdh (homo-isocitrate dehydrogenase) in L-lysine biosynthesis

Or see clustering for step hicdh

Or see all steps for L-lysine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hicdh

Curated proteins or TIGRFams with EC 1.1.1.87
Curated proteins or TIGRFams with EC 1.1.1.286
Comment: homoisocitrate to 2-oxoadipate. This rule also matches some isocitrate/homoisocitrate dehydrogenases (1.1.1.286) which often have multiple subunits in eukaryotes; this is not represented here.

Fetched 14 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 48 other characterized sequences. (Found 62 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for hicdh.)

IDH3A_PIG / P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Sus scrofa (Pig)
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, SwissProt::P56471
98% identical to

P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.286) from Homo sapiens
IDH3A_HUMAN / P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Homo sapiens (Human)
P50213 isocitrate dehydrogenase (NAD+) (subunit 2/2) (EC 1.1.1.41) from Homo sapiens
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD

IDH3A_MOUSE / Q9D6R2 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Mus musculus (Mouse)
Q9D6R2 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Mus musculus
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, BRENDA::Q9D6R2
97% identical to

IDH3A_RAT / Q99NA5 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Rattus norvegicus (Rat)
Q99NA5 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Rattus norvegicus
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, BRENDA::Q99NA5
97% identical to

IDH3A_BOVIN / P41563 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitrate dehydrogenase subunits 3/4; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Bos taurus (Bovine)
PFams: Iso_dh
Heteromeric, 366 amino acids: PaperBLAST, CDD, SwissProt::P41563
97% identical to

IDH6_ARATH / Q8LG77 Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial; IDH-VI; Isocitric dehydrogenase 6; NAD(+)-specific ICDH 6; EC 1.1.1.41 from Arabidopsis thaliana (Mouse-ear cress)
Q8LG77 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana
PFams: Iso_dh
Heteromeric, 374 amino acids: PaperBLAST, CDD, BRENDA::Q8LG77
88% identical to

Q945K7 NAD+-dependent isocitrate dehydrogenase catalytic subunit (EC 1.1.1.286) from Arabidopsis thaliana
IDH5_ARATH / Q945K7 Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial; IDH-V; Isocitric dehydrogenase 5; NAD(+)-specific ICDH 5; EC 1.1.1.41 from Arabidopsis thaliana (Mouse-ear cress)
Q945K7 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana
PFams: Iso_dh
Heteromeric, 374 amino acids: PaperBLAST, CDD

IDH1_ARATH / Q8LFC0 Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; IDH-I; Isocitric dehydrogenase 1; NAD(+)-specific ICDH 1 from Arabidopsis thaliana (Mouse-ear cress)
Q8LFC0 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana
PFams: Iso_dh
Heteromeric, 367 amino acids: PaperBLAST, CDD, BRENDA::Q8LFC0
87% identical to

P93032 NAD+-dependent isocitrate dehydrogenase regulatory subunit (EC 1.1.1.286) from Arabidopsis thaliana
IDH2_ARATH / P93032 Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial; IDH-II; Isocitric dehydrogenase 2; NAD(+)-specific ICDH 2 from Arabidopsis thaliana (Mouse-ear cress)
P93032 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana
PFams: Iso_dh
Heteromeric, 367 amino acids: PaperBLAST, CDD

IDH3_ARATH / O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial; IDH-III; Isocitric dehydrogenase 3; NAD(+)-specific ICDH 3 from Arabidopsis thaliana (Mouse-ear cress)
O81796 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Arabidopsis thaliana
PFams: Iso_dh
Heteromeric, 368 amino acids: PaperBLAST, CDD, BRENDA::O81796
80% identical to

IDH3A_CAEEL / Q93714 Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; EC 1.1.1.41 from Caenorhabditis elegans
PFams: Iso_dh
Heteromeric, 358 amino acids: PaperBLAST, CDD, SwissProt::Q93714
69% identical to

IDHG2_MOUSE / Q8BPC6 Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; Isocitric dehydrogenase subunit gamma 2; NAD(+)-specific ICDH subunit gamma 2 from Mus musculus (Mouse)
PFams: Iso_dh
Heteromeric, 396 amino acids: PaperBLAST, CDD, SwissProt::Q8BPC6
66% identical to

P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC 1.1.1.286) from Homo sapiens
IDH3G_HUMAN / P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma from Homo sapiens (Human)
P51553 isocitrate dehydrogenase (NAD+) (subunit 1/3) (EC 1.1.1.41) from Homo sapiens
PFams: Iso_dh
Heteromeric, 393 amino acids: PaperBLAST, CDD

RF|NP_595203.1 isocitrate dehydrogenase (NAD+) subunit 2; EC 1.1.1.41 from Schizosaccharomyces pombe
PFams: Iso_dh
378 amino acids: PaperBLAST, CDD, CharProtDB::CH_125980
62% identical to

P28241 isocitrate dehydrogenase [NAD] β subunit (EC 1.1.1.286) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
IDH2_YEAST / P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; Isocitric dehydrogenase; NAD(+)-specific ICDH; EC 1.1.1.41 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P28241 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Saccharomyces cerevisiae
PFams: Iso_dh
Heteromeric, 369 amino acids: PaperBLAST, CDD

IDH2_SCHPO / Q9USP8 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; Isocitric dehydrogenase; NAD(+)-specific ICDH; EC 1.1.1.41 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Iso_dh
379 amino acids: PaperBLAST, CDD, SwissProt::Q9USP8
62% identical to

G1APK3 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Rhodotorula toruloides
PFams: Iso_dh
371 amino acids: PaperBLAST, CDD, BRENDA::G1APK3
61% identical to

G1APK2 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Rhodotorula toruloides
PFams: Iso_dh
373 amino acids: PaperBLAST, CDD, BRENDA::G1APK2
58% identical to

P28834 isocitrate dehydrogenase [NAD] α subunit (EC 1.1.1.286) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
IDH1_YEAST / P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; Isocitric dehydrogenase; NAD(+)-specific ICDH; EC 1.1.1.41 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P28834 isocitrate dehydrogenase (NAD+) (EC 1.1.1.41) from Saccharomyces cerevisiae
PFams: Iso_dh
Heteromeric, 360 amino acids: PaperBLAST, CDD

IDH1_SCHPO / O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; Isocitric dehydrogenase; NAD(+)-specific ICDH; EC 1.1.1.41 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
RF|NP_594397.1 isocitrate dehydrogenase (NAD+) subunit 1 Idh1; EC 1.1.1.41 from Schizosaccharomyces pombe
PFams: Iso_dh
356 amino acids: PaperBLAST, CDD, CharProtDB::CH_124489
57% identical to

Q58130 3-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
LEU3_METJA / Q58130 3-isopropylmalate/3-methylmalate dehydrogenase; 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; IPMDH; Beta-IPM dehydrogenase; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.85; EC 1.1.1.n5; EC 1.1.1.83 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: Iso_dh
333 amino acids: PaperBLAST, CDD, SwissProt::Q58130
53% identical to

Q5SIJ1 homoisocitrate dehydrogenase subunit (EC 1.1.1.87) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
HICDH_THET8 / Q5SIJ1 Isocitrate/homoisocitrate dehydrogenase; Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.286 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
HICDH_THET2 / Q72IW9 Isocitrate/homoisocitrate dehydrogenase; Homoisocitrate dehydrogenase; HICDH; EC 1.1.1.286 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Q5SIJ1 homoisocitrate dehydrogenase (EC 1.1.1.87) from Thermus thermophilus
PFams: Iso_dh
334 amino acids: PaperBLAST, CDD

P96318 isocitrate dehydrogenase (NADP+) (EC 1.1.1.42) from Caldococcus noboribetus
PFams: Iso_dh
429 amino acids: PaperBLAST, CDD, BRENDA::P96318
53% identical to