GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for lysN (2-aminoadipate:2-oxoglutarate aminotransferase) in L-lysine biosynthesis

Or see other characterized proteins similar to lysN

Or see all steps for L-lysine biosynthesis

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Definition of lysN

Fetched 9 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 2 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 425-491 amino acids (not heteromeric)

Q64602 α-aminoadipate aminotransferase subunit (EC 2.6.1.39) from Rattus norvegicus
AADAT_RAT / Q64602 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Rattus norvegicus (Rat)
Q64602 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Rattus norvegicus
PFams: Aminotran_1_2
425 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D8PG20 2-aminoadipate transaminase (EC 2.6.1.39); aromatic-amino-acid transaminase (EC 2.6.1.57) from Candida albicans
PFams: Aminotran_1_2
491 amino acids: PaperBLAST, CDD, Compare to cluster

Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (EC 2.6.1.7; EC 2.6.1.39) from Homo sapiens
AADAT_HUMAN / Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Homo sapiens (Human)
Q8N5Z0 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Homo sapiens
PFams: Aminotran_1_2, Asp_aminotransf
425 amino acids: PaperBLAST, CDD, Compare to cluster

AADAT_MOUSE / Q9WVM8 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Glycine transaminase AADAT; Kynurenine aminotransferase II; Kynurenine--glyoxylate transaminase AADAT; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; Methionine--glyoxylate transaminase AADAT; EC 2.6.1.39; EC 2.6.1.4; EC 2.6.1.63; EC 2.6.1.7; EC 2.6.1.73 from Mus musculus (Mouse)
Q9WVM8 2-aminoadipate transaminase (EC 2.6.1.39); kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Mus musculus
PFams: Aminotran_1_2
425 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 397-397 amino acids (not heteromeric)

LYSN_THET2 / Q72LL6 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT; EC 2.6.1.39 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Q72LL6 2-aminoadipate transaminase (EC 2.6.1.39) from Thermus thermophilus
PFams: Aminotran_1_2, Asp_aminotransf
397 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SL82 L-2-aminoadipate aminotransferase monomer (EC 2.6.1.39) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: Aminotran_1_2, Asp_aminotransf
397 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

P53090 aromatic amino acid/aminoadipate aminotransferase monomer (EC 2.6.1.39; EC 2.6.1.1; EC 2.6.1.28) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ARO8_YEAST / P53090 Aromatic/aminoadipate aminotransferase 1; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Aromatic amino acid aminotransferase 1; Aromatic amino acid aminotransferase I; Aromatic amino acid-requiring protein 8; EC 2.6.1.39; EC 2.6.1.57 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P53090 2-aminoadipate transaminase (EC 2.6.1.39); aromatic-amino-acid transaminase (EC 2.6.1.57) from Saccharomyces cerevisiae
PFams: Aminotran_1_2
500 amino acids: PaperBLAST, CDD
(similar to BRENDA::A0A1D8PG20 from Cluster 1, but similarity to seed sequence is below thresholds)

SMc04386 2-aminoadipate:2-oxoglutarate aminotransferase (EC 2.6.1.39) from Sinorhizobium meliloti 1021
AAT_RHIME / P58350 Aspartate aminotransferase; AAT; AspAT; Putative 2-aminoadipate transaminase; Transaminase A; EC 2.6.1.1; EC 2.6.1.39 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
PFams: Aminotran_1_2, DegT_DnrJ_EryC1
410 amino acids: PaperBLAST, CDD

PP_4108 2-aminoadipate transaminase (EC 2.6.1.39) from Pseudomonas putida KT2440
Q88FI7 4-aminobutyrate aminotransferase (EC 2.6.1.39) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
2AAAT_PSEPK / Q88FI7 2-aminoadipate transaminase; 2-aminoadipate aminotransferase; L-2AA aminotransferase; EC 2.6.1.39 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
PFams: Aminotran_3
416 amino acids: PaperBLAST, CDD