Clusters of Characterized Proteins

Clustering the characterized proteins for mesD (oxygen-dependent methionine synthase, methyltransferase component MesD) in L-methionine biosynthesis

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Definition of mesD

• UniProt sequence Q6F6Z8: SubName: Full=5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase {ECO:0000313|EMBL:CAG70167.1}; EC=2.1.1.14 {ECO:0000313|EMBL:CAG70167.1};
• Curated sequence Ga0059261_2929: oxygen-dependent methionine synthase, methyltransferase component MesD
• Comment: Genetic evidence shows that ACIAD3523 and Ga0059261_2929 are methionine synthases, see PMC2290942 and PMID:33534785. They require mesX (ACIAD3524 or Ga0059261_2928) and oxygen for activity, but not 5-methyltetrahydrofolates or cobalamin.

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by cluster

Organism unknown

Q6F6Z8 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; EC=2.1.1.14
344 amino acids: PaperBLAST, CDD (Cluster 1)

Sphingomonas koreensis

Ga0059261_2929 oxygen-dependent methionine synthase, methyltransferase component MesD from Sphingomonas koreensis DSMZ 15582
PFams: Meth_synt_2
Heteromeric, 342 amino acids: PaperBLAST, CDD (Cluster 1)