Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for metA (homoserine O-succinyltransferase) in L-methionine biosynthesis

Or see other characterized proteins similar to metA

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metA

Curated proteins or TIGRFams with EC 2.3.1.46
Comment: As discussed in PMID:28581482, many homologs of MetA family are actually homoserine O-acetyltransferases, and many homologs of MetX are actually homoserine O-succinyltransferases. Fortunately, many enzymes of both types have been curated in Swiss-Prot.

Fetched 54 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 54 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 301-360 amino acids (not heteromeric)

Q3IHM8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
315 amino acids: PaperBLAST, CDD, Compare to cluster

HOMSUCTRAN-MONOMER homoserine O-succinyltransferase (EC 2.3.1.46)
P07623 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
P07623 homoserine O-succinyltransferase (EC 2.3.1.46)
CH_004029 homoserine O-succinyltransferase; EC 2.3.1.46
PFams: HTS
309 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0D8BWP6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
302 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D3PCI9 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
333 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D3PCJ5 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
325 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D3PDD4 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
309 amino acids: PaperBLAST, CDD, Compare to cluster

A1A3D2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
344 amino acids: PaperBLAST, CDD, Compare to cluster

A5IIQ2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
Q9WZY3 Homoserine O-acetyltransferase; HAT; HTS-like HTA; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
304 amino acids: PaperBLAST, CDD, Compare to cluster

A5N8M0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
309 amino acids: PaperBLAST, CDD, Compare to cluster

A6LC32 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
310 amino acids: PaperBLAST, CDD, Compare to cluster

A6WLE9 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
313 amino acids: PaperBLAST, CDD, Compare to cluster

B4RUL1 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
312 amino acids: PaperBLAST, CDD, Compare to cluster

C7C8V4 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
331 amino acids: PaperBLAST, CDD, Compare to cluster

C8NA81 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
350 amino acids: PaperBLAST, CDD, Compare to cluster

D3RNP0 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
357 amino acids: PaperBLAST, CDD, Compare to cluster

E2NPN0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
312 amino acids: PaperBLAST, CDD, Compare to cluster

E3H7X6 Homoserine O-acetyltransferase 1; HAT 1; Homoserine transacetylase 1; HTA 1; EC 2.3.1.31 (from HMM only)
PFams: HTS
302 amino acids: PaperBLAST, CDD, Compare to cluster

E8LIC0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

G3ISL7 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
354 amino acids: PaperBLAST, CDD, Compare to cluster

G4RES5 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
306 amino acids: PaperBLAST, CDD, Compare to cluster

I3BN39 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
360 amino acids: PaperBLAST, CDD, Compare to cluster

L0E1U3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
356 amino acids: PaperBLAST, CDD, Compare to cluster

M4YMP0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
307 amino acids: PaperBLAST, CDD, Compare to cluster

M9SGV8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
309 amino acids: PaperBLAST, CDD, Compare to cluster

P54167 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q0BX37 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Q15RG1 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
308 amino acids: PaperBLAST, CDD, Compare to cluster

Q2GAJ2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q3J205 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Q3J7P0 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS, GATase
358 amino acids: PaperBLAST, CDD, Compare to cluster

Q3SM51 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
349 amino acids: PaperBLAST, CDD, Compare to cluster

Q5LHS7 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Q5LSN6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
312 amino acids: PaperBLAST, CDD, Compare to cluster

Q606Y5 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: HTS
355 amino acids: PaperBLAST, CDD, Compare to cluster

Q72X44 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q7CWE8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
MONOMER-17841 homoserine O-acetyltransferase (EC 2.3.1.31) (from HMM only)
PFams: HTS
308 amino acids: PaperBLAST, CDD, Compare to cluster

Q814M3 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

R9T6W8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only)
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 367-424 amino acids (not heteromeric)

A0A0I9QGZ7 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0I9RJ56 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46
PFams: Abhydrolase_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

A9I0E6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
424 amino acids: PaperBLAST, CDD, Compare to cluster

B7X2B6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
409 amino acids: PaperBLAST, CDD, Compare to cluster

D0L1T6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
403 amino acids: PaperBLAST, CDD, Compare to cluster

H8L374 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46
PFams: Abhydrolase_1, Abhydrolase_6
367 amino acids: PaperBLAST, CDD, Compare to cluster

P57714 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

Q2T284 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
381 amino acids: PaperBLAST, CDD, Compare to cluster

Q4ZZ78 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

Q6FEQ3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
387 amino acids: PaperBLAST, CDD, Compare to cluster

Q88CT3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

Q8P8L2 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46
PFams: Abhydrolase_1
380 amino acids: PaperBLAST, CDD, Compare to cluster

S2KHP1 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46
PFams: Abhydrolase_1, Esterase
367 amino acids: PaperBLAST, CDD, Compare to cluster

S2L5R8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1
390 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 369-369 amino acids (not heteromeric)

F4QV02 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1, Abhydrolase_6
369 amino acids: PaperBLAST, CDD, Compare to cluster

Q8P6V8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46
PFams: Abhydrolase_1, Abhydrolase_6
369 amino acids: PaperBLAST, CDD, Compare to cluster