Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for metA (homoserine O-succinyltransferase) in L-methionine biosynthesis

Or see other characterized proteins similar to metA

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metA

Curated proteins or TIGRFams with EC 2.3.1.46
Comment: As discussed in PMID:28581482, many members of the MetA family are actually homoserine O-acetyltransferases, and many members of the MetX family are actually homoserine O-succinyltransferases. Fortunately, many enzymes of both types have been curated in Swiss-Prot.

Fetched 54 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 54 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by cluster

Acinetobacter baylyi

METXS_ACIAD / Q6FEQ3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
PFams: Abhydrolase_1
387 amino acids: PaperBLAST, CDD (Cluster 2)

Agrobacterium fabrum

Q7CWE8 homoserine O-acetyltransferase (EC 2.3.1.31) (from HMM only) from Agrobacterium fabrum (strain C58 / ATCC 33970)
METAA_AGRFC / Q7CWE8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
PFams: HTS
308 amino acids: PaperBLAST, CDD (Cluster 1)

Alkalihalobacillus clausii

METAA_ALKCL / A0A1D3PDD4 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Alkalihalobacillus clausii (Bacillus clausii)
PFams: HTS
309 amino acids: PaperBLAST, CDD (Cluster 1)

Allochromatium vinosum

METAS_ALLVD / D3RNP0 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) (Chromatium vinosum)
PFams: HTS
357 amino acids: PaperBLAST, CDD (Cluster 1)

Alteromonas mediterranea

METAS_ALTMD / B4RUL1 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
PFams: HTS
312 amino acids: PaperBLAST, CDD (Cluster 1)

Bacillus cereus

METAA_BACC1 / Q72X44 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 from Bacillus cereus (strain ATCC 10987 / NRS 248)
Q72X44 homoserine O-succinyltransferase (EC 2.3.1.46) from Bacillus cereus
PFams: HTS
301 amino acids: PaperBLAST, CDD (Cluster 1)

METAA_BACCR / Q814M3 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
PFams: HTS
301 amino acids: PaperBLAST, CDD (Cluster 1)

Bacillus subtilis

METAA_BACSU / P54167 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Bacillus subtilis (strain 168)
PFams: HTS
301 amino acids: PaperBLAST, CDD (Cluster 1)

Bacteroides fragilis

METAA_BACFN / Q5LHS7 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)
PFams: HTS
305 amino acids: PaperBLAST, CDD (Cluster 1)

Bifidobacterium adolescentis

METAA_BIFAA / A1A3D2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
PFams: HTS
344 amino acids: PaperBLAST, CDD (Cluster 1)

Bordetella petrii

METXS_BORPD / A9I0E6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
PFams: Abhydrolase_1
424 amino acids: PaperBLAST, CDD (Cluster 2)

Bradyrhizobium japonicum

METAS_BRAJP / A0A1D3PCJ5 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Bradyrhizobium japonicum
PFams: HTS
325 amino acids: PaperBLAST, CDD (Cluster 1)

Brevundimonas diminuta

METXS_BREDA / F4QV02 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Brevundimonas diminuta (strain ATCC 11568 / DSM 7234 / NBRC 12697 / NCIMB 9393 / NCTC 8545)
PFams: Abhydrolase_6, Abhydrolase_1, Hydrolase_4
369 amino acids: PaperBLAST, CDD (Cluster 3)

Burkholderia thailandensis

METXS_BURTA / Q2T284 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CCUG 48851 / CIP 106301 / E264)
PFams: Abhydrolase_1
381 amino acids: PaperBLAST, CDD (Cluster 2)

Cardiobacterium hominis

METAS_CARH6 / C8NA81 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Cardiobacterium hominis (strain ATCC 15826 / DSM 8339 / NCTC 10426 / 6573)
PFams: HTS
350 amino acids: PaperBLAST, CDD (Cluster 1)

Catenibacterium mitsuokai

METAA_CATMR / E2NPN0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Catenibacterium mitsuokai (strain DSM 15897 / JCM 10609 / CIP 106738 / RCA14-39)
PFams: HTS
312 amino acids: PaperBLAST, CDD (Cluster 1)

Cereibacteraeroides (strain

METAA_CERS4 / Q3J205 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides)
PFams: HTS
305 amino acids: PaperBLAST, CDD (Cluster 1)

Clostridium kluyveri

METAA_CLOK5 / A5N8M0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: HTS
309 amino acids: PaperBLAST, CDD (Cluster 1)

Comamonas testosteroni

METXS_COMTK / B7X2B6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Comamonas testosteroni (strain DSM 14576 / KF-1)
PFams: Abhydrolase_1
409 amino acids: PaperBLAST, CDD (Cluster 2)

Escherichia coli

b4013 homoserine O-succinyltransferase (EC 2.3.1.46) from Escherichia coli K-12 substr. MG1655
P07623 homoserine O-succinyltransferase (EC 2.3.1.46) from Escherichia coli (strain K12)
METAS_ECOLI / P07623 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Escherichia coli (strain K12)
P07623 homoserine O-succinyltransferase (EC 2.3.1.46) from Escherichia coli
CH_004029 homoserine O-succinyltransferase; EC 2.3.1.46 from Escherichia coli K12
PFams: HTS
309 amino acids: PaperBLAST, CDD (Cluster 1)

Frateuria aurantia

SST_FRAAD / H8L374 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Frateuria aurantia (strain ATCC 33424 / DSM 6220 / KCTC 2777 / LMG 1558 / NBRC 3245 / NCIMB 13370) (Acetobacter aurantius)
PFams: Abhydrolase_1
367 amino acids: PaperBLAST, CDD (Cluster 2)

Geobacillus kaustophilus

METAA_GEOKU / A0A0D8BWP6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Geobacillus kaustophilus
PFams: HTS
302 amino acids: PaperBLAST, CDD (Cluster 1)

Halomonas anticariensis

SST_HALAF / S2KHP1 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Halomonas anticariensis (strain DSM 16096 / CECT 5854 / LMG 22089 / FP35)
PFams: Abhydrolase_1, Esterase
367 amino acids: PaperBLAST, CDD (Cluster 2)

METXS_HALAF / S2L5R8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Halomonas anticariensis (strain DSM 16096 / CECT 5854 / LMG 22089 / FP35)
PFams: Abhydrolase_1
390 amino acids: PaperBLAST, CDD (Cluster 2)

Halothiobacillus neapolitanus

METXS_HALNC / D0L1T6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)
PFams: Abhydrolase_1
403 amino acids: PaperBLAST, CDD (Cluster 2)

Hyphomonas neptunium

METAA_HYPNA / Q0BX37 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Hyphomonas neptunium (strain ATCC 15444)
PFams: HTS
305 amino acids: PaperBLAST, CDD (Cluster 1)

Ilyobacter polytropus

META1_ILYPC / E3H7X6 Homoserine O-acetyltransferase 1; HAT 1; Homoserine transacetylase 1; HTA 1; EC 2.3.1.31 (from HMM only) from Ilyobacter polytropus (strain ATCC 51220 / DSM 2926 / LMG 16218 / CuHBu1)
PFams: HTS
302 amino acids: PaperBLAST, CDD (Cluster 1)

Methanomassiliicoccus intestinalis

METAA_METII / R9T6W8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Methanomassiliicoccus intestinalis (strain Issoire-Mx1)
PFams: HTS
305 amino acids: PaperBLAST, CDD (Cluster 1)

Methanomethylophilus alvus

METAA_METAX / M9SGV8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Methanomethylophilus alvus (strain Mx1201)
PFams: HTS
309 amino acids: PaperBLAST, CDD (Cluster 1)

Methylobacter tundripaludum

METAS_METTV / G3ISL7 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Methylobacter tundripaludum (strain ATCC BAA-1195 / DSM 17260 / SV96)
PFams: HTS
354 amino acids: PaperBLAST, CDD (Cluster 1)

Methylococcus capsulatus

METAS_METCA / Q606Y5 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
PFams: HTS
355 amino acids: PaperBLAST, CDD (Cluster 1)

Methylorubrum extorquens

METAS_METED / C7C8V4 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4) (Methylobacterium extorquens)
PFams: HTS
331 amino acids: PaperBLAST, CDD (Cluster 1)

Neisseria gonorrhoeae

METXS_NEIGO / A0A0I9QGZ7 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Neisseria gonorrhoeae
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD (Cluster 2)

Nitrosococcus oceani

METAS_NITOC / Q3J7P0 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)
PFams: HTS, GATase
358 amino acids: PaperBLAST, CDD (Cluster 1)

Novosphingobium aromaticivorans

METAA_NOVAD / Q2GAJ2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)
PFams: HTS
301 amino acids: PaperBLAST, CDD (Cluster 1)

Parabacteroides distasonis

METAA_PARD8 / A6LC32 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)
PFams: HTS
310 amino acids: PaperBLAST, CDD (Cluster 1)

Pelagibacterium halotolerans

METAS_PELHB / G4RES5 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pelagibacterium halotolerans (strain DSM 22347 / JCM 15775 / CGMCC 1.7692 / B2)
PFams: HTS
306 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudoalteromonas atlantica

METAS_PSEA6 / Q15RG1 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
PFams: HTS
308 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudoalteromonas translucida

METAS_PSET1 / Q3IHM8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudoalteromonas translucida (strain TAC 125)
PFams: HTS
315 amino acids: PaperBLAST, CDD (Cluster 1)

Pseudomonas aeruginosa

METXS_PSEAE / P57714 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD (Cluster 2)

Pseudomonas putida

METXS_PSEPK / Q88CT3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD (Cluster 2)

Pseudomonas syringae

METXS_PSEU2 / Q4ZZ78 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudomonas syringae pv. syringae (strain B728a)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD (Cluster 2)

Rhodopseudomonas palustris

METAS_RHOPL / A0A1D3PCI9 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Rhodopseudomonas palustris
PFams: HTS
333 amino acids: PaperBLAST, CDD (Cluster 1)

Ruegeria pomeroyi

METAA_RUEPO / Q5LSN6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
PFams: HTS
312 amino acids: PaperBLAST, CDD (Cluster 1)

Shewanella baltica

METAS_SHEB8 / A6WLE9 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Shewanella baltica (strain OS185)
PFams: HTS
313 amino acids: PaperBLAST, CDD (Cluster 1)

Stenotrophomonas maltophilia

SST_STEMA / A0A0I9RJ56 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
PFams: Abhydrolase_1
370 amino acids: PaperBLAST, CDD (Cluster 2)

Succinatimonas hippei

METAA_SUCHY / E8LIC0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Succinatimonas hippei (strain DSM 22608 / JCM 16073 / KCTC 15190 / YIT 12066)
PFams: HTS
301 amino acids: PaperBLAST, CDD (Cluster 1)

Thermoplasmatales archaeon

METAA_THEXX / M4YMP0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Thermoplasmatales archaeon (strain BRNA1)
PFams: HTS
307 amino acids: PaperBLAST, CDD (Cluster 1)

Thermotoga maritima

METAA_THEMA / Q9WZY3 Homoserine O-acetyltransferase; HAT; HTS-like HTA; Homoserine transacetylase; HTA; EC 2.3.1.31 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
METAA_THEP1 / A5IIQ2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 (from HMM only) from Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)
PFams: HTS
304 amino acids: PaperBLAST, CDD (Cluster 1)

Thermotoga petrophila

Thioalkalivibrio nitratireducens

METAS_THIND / L0E1U3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Thioalkalivibrio nitratireducens (strain DSM 14787 / UNIQEM 213 / ALEN2)
PFams: HTS
356 amino acids: PaperBLAST, CDD (Cluster 1)

Thiobacillus denitrificans

METAS_THIDA / Q3SM51 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Thiobacillus denitrificans (strain ATCC 25259)
PFams: HTS
349 amino acids: PaperBLAST, CDD (Cluster 1)

Thiothrix nivea

METAS_THINJ / I3BN39 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Thiothrix nivea (strain ATCC 35100 / DSM 5205 / JP2)
PFams: HTS
360 amino acids: PaperBLAST, CDD (Cluster 1)

Xanthomonas campestris

METXS_XANCP / Q8P6V8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
PFams: Abhydrolase_6, Abhydrolase_1
369 amino acids: PaperBLAST, CDD (Cluster 3)

SST_XANCP / Q8P8L2 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
PFams: Abhydrolase_1
380 amino acids: PaperBLAST, CDD (Cluster 2)