Clusters of Characterized Proteins

Clustering the characterized proteins for metB (cystathionine gamma-synthase) in L-methionine biosynthesis

Or see other characterized proteins similar to metB

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metB

• Curated sequence O31631: Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase; CGS/OAH thiolyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase; EC 2.5.1.-
• Curated proteins or TIGRFams with EC 2.5.1.48
• Comment: METI_BACSU (O31631) has activity as CGS but is given a more vague EC number.

Fetched 13 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 13 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 373-388 amino acids (not heteromeric)

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48)
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD, Compare to cluster

Q1M0P5 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48
Q1M0P5 cystathionine gamma-synthase (EC 2.5.1.48)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
380 amino acids: PaperBLAST, CDD, Compare to cluster

O31631 Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase; CGS/OAH thiolyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase; EC 2.5.1.-
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
373 amino acids: PaperBLAST, CDD, Compare to cluster

O-SUCCHOMOSERLYASE-MONOMER O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase (EC 2.5.1.48)
P00935 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48
PFams: Cys_Met_Meta_PP, Aminotran_1_2
386 amino acids: PaperBLAST, CDD, Compare to cluster

P9WGB7 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1
388 amino acids: PaperBLAST, CDD, Compare to cluster

HP0106-MONOMER cystathionine γ-lyase (EC 2.5.1.48)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
380 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 575-649 amino acids (not heteromeric)

O74314 Probable cystathionine gamma-synthase; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48
PFams: Cys_Met_Meta_PP
610 amino acids: PaperBLAST, CDD, Compare to cluster

P47164 Cystathionine gamma-synthase; O-succinylhomoserine (thiol)-lyase; Sulfur transfer protein 2; EC 2.5.1.48
PFams: Cys_Met_Meta_PP
639 amino acids: PaperBLAST, CDD, Compare to cluster

Q04533 Putative cystathionine gamma-synthase YML082W; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48
PFams: Cys_Met_Meta_PP
649 amino acids: PaperBLAST, CDD, Compare to cluster

Q12198 Putative cystathionine gamma-synthase YLL058W; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48
PFams: Cys_Met_Meta_PP
575 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 534-563 amino acids (not heteromeric)

P55217 Cystathionine gamma-synthase 1, chloroplastic; AtCGS1; METHIONINE OVERACCUMULATION 1; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48
PFams: Cys_Met_Meta_PP, Beta_elim_lyase
563 amino acids: PaperBLAST, CDD, Compare to cluster

L0EK12 cystathionine gamma-synthase (EC 2.5.1.48)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Beta_elim_lyase
534 amino acids: PaperBLAST, CDD, Compare to cluster

L0EKR2 cystathionine gamma-synthase (EC 2.5.1.48)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Beta_elim_lyase
535 amino acids: PaperBLAST, CDD, Compare to cluster