GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for metH (vitamin B12-dependent methionine synthase) in L-methionine biosynthesis

Or see other characterized proteins similar to metH

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metH

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 1221-1265 amino acids (not heteromeric)

HOMOCYSMETB12-MONOMER cobalamin-dependent methionine synthase (EC 2.1.1.13)
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13
P13009 methionine synthase (EC 2.1.1.13)
HOMOCYSMETB12-MONOMER cobalamin-dependent methionine synthase (EC 2.1.1.13)
CH_090726 methionine synthase; EC 2.1.1.13
PFams: S-methyl_trans, Pterin_bind, B12-binding_2, B12-binding, Met_synt_B12
1227 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Z2Q4 methionine synthase (EC 2.1.1.13)
PFams: S-methyl_trans, Pterin_bind, B12-binding_2, B12-binding, Met_synt_B12
1253 amino acids: PaperBLAST, CDD, Compare to cluster

Q99707 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Vitamin-B12 dependent methionine synthase; MS; EC 2.1.1.13
HS04076-MONOMER methionine synthase (EC 2.1.1.13)
PFams: S-methyl_trans, Pterin_bind, B12-binding_2, B12-binding, Met_synt_B12
1265 amino acids: PaperBLAST, CDD, Compare to cluster

G18NG-11090-MONOMER cob(I)alamin-dependent methionine synthase (EC 2.1.1.13)
PFams: S-methyl_trans, Pterin_bind, B12-binding_2, B12-binding, Met_synt_B12
1221 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 768-818 amino acids (not heteromeric)

Q9WYA5 methionine synthase (EC 2.1.1.13)
PFams: S-methyl_trans, Pterin_bind, B12-binding_2, B12-binding
768 amino acids: PaperBLAST, CDD, Compare to cluster

B8DKK4_DESVM 5-methyltetrahydrofolate--homocysteine methyltransferase; EC=2.1.1.13; Methionine synthase
818 amino acids: PaperBLAST, CDD, Compare to cluster

Q72BP9_DESVH 5-methyltetrahydrofolate--homocysteine methyltransferase; EC=2.1.1.13; Methionine synthase
804 amino acids: PaperBLAST, CDD, Compare to cluster