Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for metX (homoserine O-acetyltransferase) in L-methionine biosynthesis

Or see other characterized proteins similar to metX

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metX

Curated proteins or TIGRFams with EC 2.3.1.31
Comment: MetX is often found alongside a methyltransferase-like protein MetW. Because MetW is not consistently required for MetX's activity, it is not included in GapMind. Details on MetW: PMID:28581482 briefly mention that MetX proteins lacked activity when expressed in E. coli unless MetW was cloned along with it. They purified MetX by adding an N-terminal hexahistidine tag; MetW would not necessarily be purified along with it. Most likely, MetW is either modifying MetX and improving its activity, or forming a complex with MetX and stabilizing it. Mutant fitness data for MetW from various Proteobacteria shows that MetW need not be required for MetX activity (see Herbaspirillum seropedicae or Cupriavidus necator). In other organisms, MetW mutants have milder phenotypes than MetX mutants, or MetX mutants do not have a defect in some conditions, which suggests that MetW is only sometimes required (Burkholderia phytofirmans, Acidovorax 3H11, Dechlorosoma suillum PS, Marinobacter adhaerens). This might suggest that any modification has a regulatory role. In many other organisms, there is tight cofitness between MetX and MetW, suggesting that MetW is required for MetX's activity (Paraburkholderia bryophila, many Pseudomonas, Caulobacter crescentus, or Sphingomonas koreensis).

Fetched 84 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 83 of these sequences

Found 4 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 336-540 amino acids (not heteromeric)

C4XNQ9 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
397 amino acids: PaperBLAST, CDD, Compare to cluster

D2Z028 L-serine/homoserine O-acetyltransferase; Homoserine O-trans-acetylase; EC 2.3.1.30; EC 2.3.1.31
D2Z028 serine O-acetyltransferase (EC 2.3.1.30); homoserine O-acetyltransferase (EC 2.3.1.31)
MONOMER-18015 serine O-acetyltransferase (EC 2.3.1.30)
PFams: Abhydrolase_1
374 amino acids: PaperBLAST, CDD, Compare to cluster

P39058 deacetylcephalosporin-C acetyltransferase (EC 2.3.1.175)
MONOMER-13419 deacetylcephalosporin C acetyltransferase (EC 2.3.1.175) (from HMM only)
PFams: Abhydrolase_1
444 amino acids: PaperBLAST, CDD, Compare to cluster

P94891 homoserine O-acetyltransferase (EC 2.3.1.31)
MONOMER-9364 homoserine O-acetyltransferase (EC 2.3.1.31)
CH_121547 homoserine O-acetyltransferase; EC 2.3.1.31
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0D2YG05 Homoserine O-acetyltransferase FUB5; Fusaric acid biosynthesis protein 5; EC 2.3.1.31
PFams: Abhydrolase_1
362 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0I9QGZ7 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0I9RJ56 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
370 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D3PCM3 Serine O-succinyltransferase; SST; EC 2.3.1.- (from HMM only)
PFams: Abhydrolase_1
517 amino acids: PaperBLAST, CDD, Compare to cluster

A2SQW3 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
487 amino acids: PaperBLAST, CDD, Compare to cluster

A6UNL1 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
492 amino acids: PaperBLAST, CDD, Compare to cluster

A9I0E6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
424 amino acids: PaperBLAST, CDD, Compare to cluster

A9WKM8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
378 amino acids: PaperBLAST, CDD, Compare to cluster

B3E278 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, Abhydrolase_6, Esterase
367 amino acids: PaperBLAST, CDD, Compare to cluster

B7X2B6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
409 amino acids: PaperBLAST, CDD, Compare to cluster

B8GHE0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
490 amino acids: PaperBLAST, CDD, Compare to cluster

B9L9I6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
368 amino acids: PaperBLAST, CDD, Compare to cluster

B9LTF0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
433 amino acids: PaperBLAST, CDD, Compare to cluster

D0L1T6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
403 amino acids: PaperBLAST, CDD, Compare to cluster

D3E3E4 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
490 amino acids: PaperBLAST, CDD, Compare to cluster

D3P9D1 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
377 amino acids: PaperBLAST, CDD, Compare to cluster

D4GY94 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
415 amino acids: PaperBLAST, CDD, Compare to cluster

D5E9R7 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
483 amino acids: PaperBLAST, CDD, Compare to cluster

D7E9E0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
489 amino acids: PaperBLAST, CDD, Compare to cluster

E0UR96 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
368 amino acids: PaperBLAST, CDD, Compare to cluster

F7XKY8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
492 amino acids: PaperBLAST, CDD, Compare to cluster

G0J5N4 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
351 amino acids: PaperBLAST, CDD, Compare to cluster

H8L374 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1, Abhydrolase_6
367 amino acids: PaperBLAST, CDD, Compare to cluster

K2QXP6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
493 amino acids: PaperBLAST, CDD, Compare to cluster

K4ICC9 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, Hydrolase_4
336 amino acids: PaperBLAST, CDD, Compare to cluster

M0GNC6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
415 amino acids: PaperBLAST, CDD, Compare to cluster

M0HG00 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
415 amino acids: PaperBLAST, CDD, Compare to cluster

O68640 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
MONOMER-9447 homoserine O-acetyltransferase (EC 2.3.1.31)
PFams: Abhydrolase_1
377 amino acids: PaperBLAST, CDD, Compare to cluster

P45131 Homoserine O-acetyltransferase; HAT; Homoserine O-trans-acetylase; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
358 amino acids: PaperBLAST, CDD, Compare to cluster

P57714 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

Q12XS2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
488 amino acids: PaperBLAST, CDD, Compare to cluster

Q1J115 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, Abhydrolase_6, Hydrolase_4
336 amino acids: PaperBLAST, CDD, Compare to cluster

Q2NGH9 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
490 amino acids: PaperBLAST, CDD, Compare to cluster

Q2S5A6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
352 amino acids: PaperBLAST, CDD, Compare to cluster

Q2T284 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
381 amino acids: PaperBLAST, CDD, Compare to cluster

Q3IUE8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
401 amino acids: PaperBLAST, CDD, Compare to cluster

Q3M5Q6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
359 amino acids: PaperBLAST, CDD, Compare to cluster

Q4ZZ78 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

Q5AT15 Serine O-succinyltransferase; SST; EC 2.3.1.- (from HMM only)
PFams: Abhydrolase_1
517 amino acids: PaperBLAST, CDD, Compare to cluster

Q6FEQ3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
387 amino acids: PaperBLAST, CDD, Compare to cluster

Q88CT3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD, Compare to cluster

Q8F4I0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
366 amino acids: PaperBLAST, CDD, Compare to cluster

Q8P8L2 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
380 amino acids: PaperBLAST, CDD, Compare to cluster

Q8TME4 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, CBS, CBS
540 amino acids: PaperBLAST, CDD, Compare to cluster

Q9AAS1 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1
382 amino acids: PaperBLAST, CDD, Compare to cluster

Q9RA51 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: Abhydrolase_1, Abhydrolase_6, Ndr
380 amino acids: PaperBLAST, CDD, Compare to cluster

S0DUX2 Homoserine O-acetyltransferase FUB5; Fusaric acid biosynthesis protein 5; EC 2.3.1.31
PFams: Abhydrolase_1
427 amino acids: PaperBLAST, CDD, Compare to cluster

S2KHP1 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1, Esterase
367 amino acids: PaperBLAST, CDD, Compare to cluster

S2L5R8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 (from HMM only)
PFams: Abhydrolase_1
390 amino acids: PaperBLAST, CDD, Compare to cluster

W7N293 Homoserine O-acetyltransferase FUB5; Fusaric acid biosynthesis protein 5; EC 2.3.1.31
PFams: Abhydrolase_1
463 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 262-344 amino acids (not heteromeric)

A0A0D8BWP6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
302 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D3PCK2 Serine O-acetyltransferase; SAT; Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.30; EC 2.3.1.31
PFams: HTS
262 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D3PDD4 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
309 amino acids: PaperBLAST, CDD, Compare to cluster

A1A3D2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
344 amino acids: PaperBLAST, CDD, Compare to cluster

A5IIQ2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
Q9WZY3 Homoserine O-acetyltransferase; HAT; HTS-like HTA; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
304 amino acids: PaperBLAST, CDD, Compare to cluster

A5N8M0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
309 amino acids: PaperBLAST, CDD, Compare to cluster

A6LC32 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
310 amino acids: PaperBLAST, CDD, Compare to cluster

E2NPN0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
312 amino acids: PaperBLAST, CDD, Compare to cluster

E3H7X6 Homoserine O-acetyltransferase 1; HAT 1; Homoserine transacetylase 1; HTA 1; EC 2.3.1.31
PFams: HTS
302 amino acids: PaperBLAST, CDD, Compare to cluster

E3HDJ8 Homoserine O-acetyltransferase 2; HAT 2; Homoserine transacetylase 2; HTA 2; EC 2.3.1.31
PFams: HTS
284 amino acids: PaperBLAST, CDD, Compare to cluster

E8LIC0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

M4YMP0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
307 amino acids: PaperBLAST, CDD, Compare to cluster

M9SGV8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
309 amino acids: PaperBLAST, CDD, Compare to cluster

P54167 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q03V79 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Q0BX37 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Q2GAJ2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q3J205 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Q5LHS7 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Q5LSN6 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
312 amino acids: PaperBLAST, CDD, Compare to cluster

Q72X44 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q7CWE8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
MONOMER-17841 homoserine O-acetyltransferase (EC 2.3.1.31)
PFams: HTS
308 amino acids: PaperBLAST, CDD, Compare to cluster

Q814M3 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
301 amino acids: PaperBLAST, CDD, Compare to cluster

R9T6W8 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31
PFams: HTS
305 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 486-489 amino acids (not heteromeric)

CH_122343 homoserine O-acetyltransferase; EC 2.3.1.31
PFams: Abhydrolase_1
489 amino acids: PaperBLAST, CDD, Compare to cluster

O60062 Homoserine O-acetyltransferase; Homoserine O-trans-acetylase; EC 2.3.1.31
CH_124802 homoserine O-acetyltransferase Met6; EC 2.3.1.31
PFams: Abhydrolase_1
489 amino acids: PaperBLAST, CDD, Compare to cluster

P08465 Homoserine O-acetyltransferase; Homoserine O-trans-acetylase; EC 2.3.1.31
YNL277W-MONOMER Met2 (EC 2.3.1.31)
PFams: Abhydrolase_1
486 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 504-509 amino acids (not heteromeric)

Q10341 Serine O-succinyltransferase; SST; EC 2.3.1.- (from HMM only)
CH_125687 homoserine O-acetyltransferase (predicted); EC 2.3.1.-
PFams: Abhydrolase_1
504 amino acids: PaperBLAST, CDD, Compare to cluster

I1R9N5 serine O-acetyltransferase (EC 2.3.1.30) (from HMM only)
PFams: Abhydrolase_1
509 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q7UG04 Bifunctional methionine biosynthesis protein MetXA/MetW; EC 2.3.1.31
PFams: Abhydrolase_1, MTS, MetW, Methyltransf_31, Methyltransf_25, Methyltransf_11
623 amino acids: PaperBLAST, CDD