Other Characterized Proteins Similar to metX

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to metX

Finding the characterized proteins for metX (homoserine O-acetyltransferase) in L-methionine biosynthesis

Or see clustering for step metX

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metX

Curated proteins or TIGRFams with EC 2.3.1.31
Comment: MetX is often encoded next to a methyltransferase-like protein MetW. Because MetW is not consistently required for MetX's activity, it is not included in GapMind. MetW can bind MetX and increase its activity (PMID:33604638), and in some bacteria, there is tight cofitness between MetX and MetW, which suggests that MetW is required for MetX's activity (i.e., Paraburkholderia bryophila, many Pseudomonas, Caulobacter crescentus, or Sphingomonas koreensis). But in other diverse bacteria, metW mutants can still grow in minimal media (i.e., Herbaspirillum seropedicae or Cupriavidus necator), or have milder phenotypes than metX mutants (i.e., Burkholderia phytofirmans, Acidovorax 3H11, Dechlorosoma suillum PS, Marinobacter adhaerens).

Fetched 87 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 9 other characterized sequences. (Found 96 hits including self hits.)

There are also 19 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for metX.)

EFUC_HORCR / A0A2Z4HPY5 Acetyltransferase efuC; Enfumafungin biosynthesis cluster protein C; EC 2.3.1.- from Hormonema carpetanum
PFams: Abhydrolase_1
551 amino acids: PaperBLAST, CDD, SwissProt::A0A2Z4HPY5
62% identical to

I1R9N5 serine O-acetyltransferase (EC 2.3.1.30) from Fusarium graminearum
PFams: Abhydrolase_1
509 amino acids: PaperBLAST, CDD

b4013 homoserine O-succinyltransferase (EC 2.3.1.46) from Escherichia coli K-12 substr. MG1655
P07623 homoserine O-succinyltransferase (EC 2.3.1.46) from Escherichia coli (strain K12)
METAS_ECOLI / P07623 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Escherichia coli (strain K12)
P07623 homoserine O-succinyltransferase (EC 2.3.1.46) from Escherichia coli
CH_004029 homoserine O-succinyltransferase; EC 2.3.1.46 from Escherichia coli K12
PFams: HTS
309 amino acids: PaperBLAST, CDD, BRENDA::P07623
58% identical to

METAA_SUCHY / E8LIC0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 from Succinatimonas hippei (strain DSM 22608 / JCM 16073 / KCTC 15190 / YIT 12066)
PFams: HTS
301 amino acids: PaperBLAST, CDD

METAS_PELHB / G4RES5 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pelagibacterium halotolerans (strain DSM 22347 / JCM 15775 / CGMCC 1.7692 / B2)
PFams: HTS
306 amino acids: PaperBLAST, CDD, SwissProt::G4RES5
58% identical to

METAA_HYPNA / Q0BX37 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 from Hyphomonas neptunium (strain ATCC 15444)
PFams: HTS
305 amino acids: PaperBLAST, CDD

METAS_SHEB8 / A6WLE9 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Shewanella baltica (strain OS185)
PFams: HTS
313 amino acids: PaperBLAST, CDD, SwissProt::A6WLE9
55% identical to

METAS_ALTMD / B4RUL1 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)
PFams: HTS
312 amino acids: PaperBLAST, CDD, SwissProt::B4RUL1
53% identical to

METAA_THEMA / Q9WZY3 Homoserine O-acetyltransferase; HAT; HTS-like HTA; Homoserine transacetylase; HTA; EC 2.3.1.31 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
METAA_THEP1 / A5IIQ2 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 from Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)
PFams: HTS
304 amino acids: PaperBLAST, CDD

METAS_PSEA6 / Q15RG1 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
PFams: HTS
308 amino acids: PaperBLAST, CDD, SwissProt::Q15RG1
53% identical to

METAS_PSET1 / Q3IHM8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudoalteromonas translucida (strain TAC 125)
PFams: HTS
315 amino acids: PaperBLAST, CDD, SwissProt::Q3IHM8
51% identical to

METAA_CLOK5 / A5N8M0 Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.31 from Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
PFams: HTS
309 amino acids: PaperBLAST, CDD

CYSE_LACCA / A0A120HUS7 Serine O-acetyltransferase; SAT; EC 2.3.1.30 from Lactobacillus casei
PFams: HTS
271 amino acids: PaperBLAST, CDD, SwissProt::A0A120HUS7
47% identical to

SAT_LACAI / A0A1D3PCK2 Serine O-acetyltransferase; SAT; Homoserine O-acetyltransferase; HAT; Homoserine transacetylase; HTA; EC 2.3.1.30; EC 2.3.1.31 from Lactobacillus acidophilus
PFams: HTS
262 amino acids: PaperBLAST, CDD

Q03BU2 serine O-acetyltransferase (EC 2.3.1.30) from Lacticaseibacillus casei
PFams: HTS
271 amino acids: PaperBLAST, CDD, BRENDA::Q03BU2
47% identical to

HMM-only sequences

(Since these sequences' annotations are outside the definition for metX, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

SST_SCHPO / Q10341 Serine O-succinyltransferase; SST; EC 2.3.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
CH_125687 homoserine O-acetyltransferase (predicted); EC 2.3.1.- from Schizosaccharomyces pombe
PFams: Abhydrolase_1
504 amino acids: PaperBLAST, CDD

METXS_PSEU2 / Q4ZZ78 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudomonas syringae pv. syringae (strain B728a)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD

P39058 deacetylcephalosporin C acetyltransferase (EC 2.3.1.175) from Hapsidospora chrysogena
CEFG_HAPCH / P39058 Acetyl-CoA--deacetylcephalosporin C acetyltransferase; DAC acetyltransferase; DAC-AT; DCPC-ATF; EC 2.3.1.175 from Hapsidospora chrysogena (Acremonium chrysogenum)
P39058 deacetylcephalosporin-C acetyltransferase (EC 2.3.1.175) from Acremonium chrysogenum
PFams: Abhydrolase_1
Heteromeric, 444 amino acids: PaperBLAST, CDD

METXS_BORPD / A9I0E6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
PFams: Abhydrolase_1
424 amino acids: PaperBLAST, CDD

METXS_PSEPK / Q88CT3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD

SST_STEMA / A0A0I9RJ56 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
PFams: Abhydrolase_1
370 amino acids: PaperBLAST, CDD

SST_XANCP / Q8P8L2 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
PFams: Abhydrolase_1
380 amino acids: PaperBLAST, CDD

METXS_COMTK / B7X2B6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Comamonas testosteroni (strain DSM 14576 / KF-1)
PFams: Abhydrolase_1
409 amino acids: PaperBLAST, CDD

METXS_HALAF / S2L5R8 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Halomonas anticariensis (strain DSM 16096 / CECT 5854 / LMG 22089 / FP35)
PFams: Abhydrolase_1
390 amino acids: PaperBLAST, CDD

SST_EMEND / A0A1D3PCM3 Serine O-succinyltransferase; SST; EC 2.3.1.- from Emericella nidulans (Aspergillus nidulans)
PFams: Abhydrolase_1
517 amino acids: PaperBLAST, CDD

METXS_HALNC / D0L1T6 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus neapolitanus)
PFams: Abhydrolase_1
403 amino acids: PaperBLAST, CDD

I1R9N5 serine O-acetyltransferase (EC 2.3.1.30) from Fusarium graminearum
PFams: Abhydrolase_1
509 amino acids: PaperBLAST, CDD

METXS_BURTA / Q2T284 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CCUG 48851 / CIP 106301 / E264)
PFams: Abhydrolase_1
381 amino acids: PaperBLAST, CDD

SST_FRAAD / H8L374 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Frateuria aurantia (strain ATCC 33424 / DSM 6220 / KCTC 2777 / LMG 1558 / NBRC 3245 / NCIMB 13370) (Acetobacter aurantius)
PFams: Abhydrolase_1
367 amino acids: PaperBLAST, CDD

METXS_ACIAD / Q6FEQ3 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
PFams: Abhydrolase_1
387 amino acids: PaperBLAST, CDD

SST_EMENI / Q5AT15 Serine O-succinyltransferase; SST; EC 2.3.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: Abhydrolase_1
517 amino acids: PaperBLAST, CDD

METXS_PSEAE / P57714 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD

METXS_NEIGO / A0A0I9QGZ7 Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.46 from Neisseria gonorrhoeae
PFams: Abhydrolase_1
379 amino acids: PaperBLAST, CDD

SST_HALAF / S2KHP1 Serine O-succinyltransferase; SST; Homoserine O-succinyltransferase; HST; Homoserine transsuccinylase; HTS; EC 2.3.1.-; EC 2.3.1.46 from Halomonas anticariensis (strain DSM 16096 / CECT 5854 / LMG 22089 / FP35)
PFams: Abhydrolase_1, Esterase
367 amino acids: PaperBLAST, CDD