Clusters of Characterized Proteins

Clustering the characterized proteins for metZ (O-succinylhomoserine sulfhydrylase) in L-methionine biosynthesis

Or see other characterized proteins similar to metZ

Or see all steps for L-methionine biosynthesis

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Definition of metZ

• Curated proteins matching O-succinylhomoserine sulfhydrylase
• Ignore hits to items matching EC 2.5.1.49 when looking for 'other' hits
• UniProt sequence A0A165KUI5_9BURK: SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KZT16112.1};
• UniProt sequence D8J1Y3_HERSS: SubName: Full=O-acetylhomoserine sulfhydrylase protein {ECO:0000313|EMBL:ADJ64766.1}; EC=2.3.1.31 {ECO:0000313|EMBL:ADJ64766.1};
• Comment: No EC number for metZ, so use "O-succinylhomoserine sulfhydrylase", which matches METZ_PSEAE and METZ_MYCTU. Two related proteins, Ac3H11_2452 (A0A165KUI5_9BURK) and HSERO_RS16440 (D8J1Y3_HERSS) are diverged metZ -- strongly cofit with homoserine succinyltransferases and similar to either sulfhydrylases or methionine gamma-lyases (but the latter function would not explain their phenotype).

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 403-415 amino acids (not heteromeric)

P55218 O-succinylhomoserine sulfhydrylase; OSH sulfhydrylase; OSHS sulfhydrylase; EC 2.5.1.-
MONOMER-13931 O-succinyl-L-homoserine sulfhydrylase
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5, DegT_DnrJ_EryC1
403 amino acids: PaperBLAST, CDD, Compare to cluster

P9WGB5 O-succinylhomoserine sulfhydrylase; OSH sulfhydrylase; OSHS sulfhydrylase; EC 2.5.1.-
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1
406 amino acids: PaperBLAST, CDD, Compare to cluster

A0A165KUI5_9BURK Uncharacterized protein
415 amino acids: PaperBLAST, CDD, Compare to cluster

D8J1Y3_HERSS O-acetylhomoserine sulfhydrylase protein; EC=2.3.1.31
413 amino acids: PaperBLAST, CDD, Compare to cluster