Other Characterized Proteins Similar to ramA

Finding the characterized proteins for ramA (ATP-dependent reduction of co(II)balamin) in L-methionine biosynthesis

Or see clustering for step ramA

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of ramA

• HMM PF14574
• Curated proteins matching ATP-dependent reduction of co(II)balamin
• Comment: As of April 2019, all characterized members of the RamA family or PF14574 are involved in the reactivation of co(II)balamin. This includes RamA (B8Y445), DvMF_1398, PGA1_c15200, and ELI_0370 (part of a O-demethylase). Many bacteria contain MetH and probably rely on a distant homolog of RamA for reactivation of B-12. PF14574 describes only the C-terminal putative ATPase domain of RamA, but no other functions are known, except for the reactivation of Co(II) corrinoid proteins (i.e. RamQ, P0DX10).

Fetched 6 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 0 other characterized sequences. (Found 6 hits including self hits.)

There are also 3 HMM-only high-coverage hits.

HMM-only sequences

(Since these sequences' annotations are outside the definition for ramA, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

RAMQ_EUBLI / P0DX10 Corrinoid activation enzyme RamQ from Eubacterium limosum
PFams: Raco_middle, RACo_C_ter
593 amino acids: PaperBLAST, CDD

B8R2M5 [Co(II) methylated amine-specific corrinoid protein] reductase (EC 1.16.99.1) from Acetobacterium dehalogenans
PFams: Raco_middle, RACo_C_ter
598 amino acids: PaperBLAST, CDD

B8Y445 [Co(II) methylated amines-specific corrinoid protein] reductase (EC 1.16.99.1) from Methanosarcina barkeri
B8Y445 [Co(II) methylated amine-specific corrinoid protein] reductase (EC 1.16.99.1) from Methanosarcina barkeri
PFams: Raco_middle, RACo_C_ter, Fer4, Fer4_21, Fer4_7, Fer4_9
540 amino acids: PaperBLAST, CDD