Other Characterized Proteins Similar to cmutase

Finding the characterized proteins for cmutase (chorismate mutase) in L-phenylalanine biosynthesis

Or see clustering for step cmutase

Or see all steps for L-phenylalanine biosynthesis

Or cluster curated proteins matching a keyword

Definition of cmutase

• Curated proteins or TIGRFams with EC 5.4.99.5
• HMM PF01817
• Curated sequence P43902: prephenate dehydrogenase (EC 1.3.1.12)
• Curated sequence Q74NC4: prephenate dehydratase (EC 4.2.1.51)
• Curated sequence A8AAX2: prephenate dehydrogenase (NADP+) (EC 1.3.1.13)
• Comment: Chorismate mutase is usually fused to prephenate dehydratase, which makes it difficult to find this activity when it is fused to something else, so we included the entire pfam in the step's definition. The only other function for this family that we are aware of is 4-amino-4-deoxychorismate mutase, which is involved in the biosynthesis of some antibiotics. (Proteins that are similar to 4-amino-4-deoxychorismate mutases will be marked as medium-confidence in the results.) Several fusion proteins are missing this EC number in their annotations (P43902, Q74NC4, A8AAX2)

Fetched 49 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 2 other characterized sequences. (Found 51 hits including self hits.)

There are also 2 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for cmutase.)

Q9WYH8 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Thermotoga maritima
PFams: DAHP_snth_FXD, DAHP_synth_1, NeuB
338 amino acids: PaperBLAST, CDD, BRENDA::Q9WYH8
53% identical to

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis
PFams: CM_2, DAHP_synth_1, NeuB
358 amino acids: PaperBLAST, CDD

Q9YEJ7 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Aeropyrum pernix
PFams: DAHP_synth_1, NeuB
270 amino acids: PaperBLAST, CDD, BRENDA::Q9YEJ7
54% identical to

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis
PFams: CM_2, DAHP_synth_1, NeuB
358 amino acids: PaperBLAST, CDD

HMM-only sequences

(Since these sequences' annotations are outside the definition for cmutase, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

F2RB77 4-amino-4-deoxychorismate mutase (EC 5.4.99.67) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
PFams: CM_2
103 amino acids: PaperBLAST, CDD

PAPB_STRPR / P72541 4-amino-4-deoxychorismate mutase; ADC mutase; EC 5.4.99.67 from Streptomyces pristinaespiralis
P72541 4-amino-4-deoxychorismate mutase (EC 5.4.99.67) from Streptomyces pristinaespiralis
PFams: CM_2
129 amino acids: PaperBLAST, CDD