Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for preph-dehydratase (prephenate dehydratase) in L-phenylalanine biosynthesis

Or see other characterized proteins similar to preph-dehydratase

Or see all steps for L-phenylalanine biosynthesis

Or cluster curated proteins matching a keyword

Definition of preph-dehydratase

Curated proteins or TIGRFams with EC 4.2.1.51
UniProt sequence Q8A0T5_BACTN: RecName: Full=Prephenate dehydratase {ECO:0000256|ARBA:ARBA00021872}; EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
Ignore hits to items matching EC 4.2.1.91 when looking for 'other' hits
UniProt sequence D4GRZ0: SubName: Full=Prephenate dehydratase {ECO:0000313|EMBL:ADE02290.1}; EC=4.2.1.51 {ECO:0000313|EMBL:ADE02290.1};
Comment: prephenate dehydratase and arogenate dehydratase can be difficult to distinguish. BT3936 (Q8A0T5_BACTN) is diverged but has auxotrophic phenotypes (as do homologs Echvi_0123, CA265_RS11630). HVO_0449 (D4GRZ0) is a phenylalanine auxotroph and is probably prephenate dehydratase (PMC4300041).

Fetched 21 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 19 of these sequences

Found 3 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 268-424 amino acids (not heteromeric)

P27603 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51
PFams: CM_2, PDT, ACT
365 amino acids: PaperBLAST, CDD, Compare to cluster

C7EXK8 prephenate dehydratase (EC 4.2.1.51)
PFams: CM_2, PDT
386 amino acids: PaperBLAST, CDD, Compare to cluster

P9WIC3 Prephenate dehydratase; PDT; EC 4.2.1.51
Q7TVJ6 Prephenate dehydratase; PDT; EC 4.2.1.51
P9WIC3 prephenate dehydratase (EC 4.2.1.51)
PFams: PDT, ACT
321 amino acids: PaperBLAST, CDD, Compare to cluster

Q6Z3Y3 prephenate dehydratase (EC 4.2.1.51)
PFams: PDT
364 amino acids: PaperBLAST, CDD, Compare to cluster

Q8DUV6 prephenate dehydratase (EC 4.2.1.51)
PFams: PDT
274 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZUY3 Arogenate dehydratase 3, chloroplastic; AtADT3; Prephenate dehydratase 1; AtPDT1; EC 4.2.1.91
Q9ZUY3 prephenate dehydratase (EC 4.2.1.51); arogenate dehydratase (EC 4.2.1.91)
PFams: PDT
424 amino acids: PaperBLAST, CDD, Compare to cluster

CHORISMUTPREPHENDEHYDRAT-MONOMER fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51)
P0A9J8 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51
CH_024084 P-protein; EC 4.2.1.51; EC 5.4.99.5
PFams: CM_2, PDT
386 amino acids: PaperBLAST, CDD, Compare to cluster

CH_124659 phrenate dehydratase; EC 4.2.1.51
PFams: PDT
287 amino acids: PaperBLAST, CDD, Compare to cluster

O14361 Putative prephenate dehydratase; PDT; EC 4.2.1.51
PFams: PDT
272 amino acids: PaperBLAST, CDD, Compare to cluster

Q58054 Prephenate dehydratase; PDT; MjPDT; EC 4.2.1.51
PFams: PDT, ACT
272 amino acids: PaperBLAST, CDD, Compare to cluster

D4GRZ0 Prephenate dehydratase; EC=4.2.1.51
268 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 282-413 amino acids (not heteromeric)

Q9SSE7 Arogenate dehydratase/prephenate dehydratase 2, chloroplastic; AtADT2; AtPDT2; EC 4.2.1.51; EC 4.2.1.91
Q9SSE7 arogenate dehydratase (EC 4.2.1.91)
PFams: PDT
381 amino acids: PaperBLAST, CDD, Compare to cluster

Q5NLV8 prephenate dehydratase (EC 4.2.1.51)
PFams: PDT
337 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SA96 Arogenate dehydratase/prephenate dehydratase 1, chloroplastic; AtADT1; AtPDT1; EC 4.2.1.51; EC 4.2.1.91
Q9SA96 arogenate dehydratase (EC 4.2.1.91)
PFams: PDT
392 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SGD6 Arogenate dehydratase/prephenate dehydratase 6, chloroplastic; AtADT6; AtPDT6; EC 4.2.1.51; EC 4.2.1.91
Q9SGD6 arogenate dehydratase (EC 4.2.1.91)
PFams: PDT
413 amino acids: PaperBLAST, CDD, Compare to cluster

Q8A0T5_BACTN Prephenate dehydratase; EC=4.2.1.51
282 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 591-620 amino acids (not heteromeric)

O30012 prephenate dehydrogenase (EC 1.3.1.12); prephenate dehydratase (EC 4.2.1.51); Chorismate mutase (EC 5.4.99.5)
PFams: PDH, CM_2, PDT, ACT
620 amino acids: PaperBLAST, CDD, Compare to cluster

Q74NC4 prephenate dehydratase (EC 4.2.1.51)
PFams: PDH, CM_2, PDT, ACT
591 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

P57472 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51
P57472 prephenate dehydratase (EC 4.2.1.51)
PFams: CM_2, PDT
385 amino acids: PaperBLAST, CDD
(similar to BRENDA::C7EXK8 from Cluster 1, but similarity to seed sequence is below thresholds)

Q01269 Cyclohexadienyl dehydratase; EC 4.2.1.51; EC 4.2.1.91
Q01269 arogenate dehydratase (EC 4.2.1.91)
PFams: SBP_bac_3
268 amino acids: PaperBLAST, CDD

P32452 Putative prephenate dehydratase; PDT; Phenylalanine-requiring protein 2; EC 4.2.1.51
PFams: PDT
334 amino acids: PaperBLAST, CDD