Other Characterized Proteins Similar to preph-dehydratase

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to preph-dehydratase

Finding the characterized proteins for preph-dehydratase (prephenate dehydratase) in L-phenylalanine biosynthesis

Or see clustering for step preph-dehydratase

Or see all steps for L-phenylalanine biosynthesis

Or cluster curated proteins matching a keyword

Definition of preph-dehydratase

Curated proteins or TIGRFams with EC 4.2.1.51
UniProt sequence Q8A0T5_BACTN: RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147}; EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
Ignore hits to items matching EC 4.2.1.91 when looking for 'other' hits
UniProt sequence D4GRZ0: SubName: Full=Prephenate dehydratase {ECO:0000313|EMBL:ADE02290.1}; EC=4.2.1.51 {ECO:0000313|EMBL:ADE02290.1};
UniProt sequence A0A160HWY7: RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147}; EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
Predicted: UniProt sequence A0A1L8CUL6: RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147}; EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
Comment: prephenate dehydratase and arogenate dehydratase can be difficult to distinguish. BT3936 (Q8A0T5_BACTN) is diverged but has auxotrophic phenotypes (as do homologs Echvi_0123, CA265_RS11630). HVO_0449 (D4GRZ0) is a phenylalanine auxotroph and is probably prephenate dehydratase (PMC4300041). A0A160HWY7 from Brevundimonas is a somewhat diverged prephenate dehydratase; it has auxotrophic phenotypes. The putative prephenate dehydratase from Carboxydothermus pertinax (A0A1L8CUL6) is lacking the regulatory (ACT) domain but has the active site residues and is often encoded near aromatic amino acid synthesis genes (it might be an arogenate dehydratase instead).

Fetched 31 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 3 other characterized sequences. (Found 30 hits including self hits.)

Removing ignored items reduces this to 0 close sequences.

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for preph-dehydratase.)

AROD1_PETHY / D3U715 Arogenate dehydratase 1; PhADT1; EC 4.2.1.91 from Petunia hybrida (Petunia)
D3U715 arogenate dehydratase (EC 4.2.1.91) from Petunia x hybrida
PFams: PDT
424 amino acids: PaperBLAST, CDD, SwissProt::D3U715
84% identical to

AROD3_PETHY / D3U717 Arogenate dehydratase 3; PhADT3; Prephenate dehydratase ADT3; EC 4.2.1.91; EC 4.2.1.51 from Petunia hybrida (Petunia)
D3U717 arogenate dehydratase (EC 4.2.1.91) from Petunia x hybrida
PFams: PDT
434 amino acids: PaperBLAST, CDD

AROD5_ARATH / Q9FNJ8 Arogenate dehydratase 5, chloroplastic; AtADT5; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress)
Q9FNJ8 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana
PFams: PDT
425 amino acids: PaperBLAST, CDD, BRENDA::Q9FNJ8
74% identical to

AROD6_ARATH / Q9SGD6 Arogenate dehydratase/prephenate dehydratase 6, chloroplastic; AtADT6; AtPDT6; EC 4.2.1.51; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress)
Q9SGD6 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana
PFams: PDT
413 amino acids: PaperBLAST, CDD

AROD4_ARATH / O22241 Arogenate dehydratase 4, chloroplastic; AtADT4; EC 4.2.1.91 from Arabidopsis thaliana (Mouse-ear cress)
O22241 arogenate dehydratase (EC 4.2.1.91) from Arabidopsis thaliana
PFams: PDT
424 amino acids: PaperBLAST, CDD, BRENDA::O22241
72% identical to