Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for argA (N-acylglutamate synthase) in L-proline biosynthesis

Or see other characterized proteins similar to argA

Or see all steps for L-proline biosynthesis

Or cluster curated proteins matching a keyword

Definition of argA

Curated proteins or TIGRFams with EC 2.3.1.1
UniProt sequence Q8A1A5_BACTN: SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAO78866.1};
UniProt sequence L0G3H4_ECHVK: SubName: Full=Acetyltransferase, N-acetylglutamate synthase {ECO:0000313|EMBL:AGA80057.1};
UniProt sequence H1XRZ0_9BACT: SubName: Full=Acetyltransferase (GNAT) family protein {ECO:0000313|EMBL:EHO42483.1}; SubName: Full=L-amino acid N-acyltransferase YncA {ECO:0000313|EMBL:APF18481.1};
Curated sequence A0A0H2X8L7: acetylglutamate kinase (EC 2.7.2.8)
UniProt sequence A0A1I2DIM7: RecName: Full=Acetylglutamate kinase {ECO:0000256|ARBA:ARBA00021197, ECO:0000256|PIRNR:PIRNR036441}; EC=2.7.2.8 {ECO:0000256|ARBA:ARBA00013065, ECO:0000256|PIRNR:PIRNR036441};
Comment: Bacteroidetes have a divergent N-acylglutamate synthase, see BT3761 (Q8A1A5_BACTN) or Echvi_3845 (L0G3H4_ECHVK). Also see the related protein Cabys_1732 (H1XRZ0_9BACT) which is reported to form N-acetylglutamate (PMID:28265262). Bacteroides use succinylated intermediates (PMID:16704984), so their proteins are probably N-succinylglutamate synthases. A0A0H2X8L7 is annotated as argB in BRENDA, but it is also argA (a fusion protein). N515DRAFT_3768 (A0A1I2DIM7) is similar to ArgAB fusion proteins and mutants are rescued by arginine.

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 22 of these sequences

Found 4 clusters of similar sequences. Another 9 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 397-468 amino acids (8/9 heteromeric)

P9WPZ3 Arginine biosynthesis bifunctional protein ArgJ; EC 2.3.1.35; EC 2.3.1.1
P9WPZ3 glutamate N-acetyltransferase (EC 2.3.1.35)
PFams: ArgJ
Heteromeric, 404 amino acids: PaperBLAST, CDD, Compare to cluster

CH_000559 glutamate N-acetyltransferase/amino-acid acetyltransferase; EC 2.3.1.35 2.3.1.1
PFams: ArgJ
406 amino acids: PaperBLAST, CDD, Compare to cluster

O94346 Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; EC 2.3.1.35; EC 2.3.1.1
PFams: ArgJ
Heteromeric, 445 amino acids: PaperBLAST, CDD, Compare to cluster

Q04728 Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Extracellular mutant protein 40; EC 2.3.1.35; EC 2.3.1.1
PFams: ArgJ
Heteromeric, 441 amino acids: PaperBLAST, CDD, Compare to cluster

Q07908 Arginine biosynthesis bifunctional protein ArgJ; EC 2.3.1.35; EC 2.3.1.1
PFams: ArgJ
Heteromeric, 410 amino acids: PaperBLAST, CDD, Compare to cluster

Q3C251 Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; EC 2.3.1.35; EC 2.3.1.1
PFams: ArgJ
Heteromeric, 460 amino acids: PaperBLAST, CDD, Compare to cluster

Q9K8V3 Arginine biosynthesis bifunctional protein ArgJ; EC 2.3.1.35; EC 2.3.1.1
PFams: ArgJ
Heteromeric, 411 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Z4S1 Arginine biosynthesis bifunctional protein ArgJ; EC 2.3.1.35; EC 2.3.1.1
PFams: ArgJ
Heteromeric, 397 amino acids: PaperBLAST, CDD, Compare to cluster

Q9ZUR7 Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; EC 2.3.1.35; EC 2.3.1.1
PFams: ArgJ
Heteromeric, 468 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 368-534 amino acids (not heteromeric)

Q87EL2 amino-acid N-acetyltransferase (EC 2.3.1.1)
PFams: AA_kinase, NAT
421 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0H2X8L7 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase, NAT
447 amino acids: PaperBLAST, CDD, Compare to cluster

A4GTP3 amino-acid N-acetyltransferase (EC 2.3.1.1)
PFams: AA_kinase, NAT
368 amino acids: PaperBLAST, CDD, Compare to cluster

Q0ASS9 amino-acid N-acetyltransferase (EC 2.3.1.1); acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase, NAT
441 amino acids: PaperBLAST, CDD, Compare to cluster

Q8N159 N-acetylglutamate synthase, mitochondrial; Amino-acid acetyltransferase; EC 2.3.1.1
Q8N159 amino-acid N-acetyltransferase (EC 2.3.1.1)
PFams: NAT
534 amino acids: PaperBLAST, CDD, Compare to cluster

Q8R4H7 N-acetylglutamate synthase, mitochondrial; Amino-acid acetyltransferase; EC 2.3.1.1
Q8R4H7 amino-acid N-acetyltransferase (EC 2.3.1.1)
PFams: NAT
527 amino acids: PaperBLAST, CDD, Compare to cluster

E7FCP8 N-acetylglutamate synthase, mitochondrial; EC 2.3.1.1
PFams: NAT
527 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1I2DIM7 Acetylglutamate kinase {ECO:0000256|ARBA:ARBA00021197, ECO:0000256|PIRNR:PIRNR036441}; EC=2.7.2.8 {ECO:0000256|ARBA:ARBA00013065, ECO:0000256|PIRNR:PIRNR036441}
438 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 192-224 amino acids (not heteromeric)

H1XRZ0_9BACT Acetyltransferase (GNAT) family protein; SubName: Full=L-amino acid N-acyltransferase YncA
202 amino acids: PaperBLAST, CDD, Compare to cluster

L0G3H4_ECHVK Acetyltransferase, N-acetylglutamate synthase
224 amino acids: PaperBLAST, CDD, Compare to cluster

Q8A1A5_BACTN Uncharacterized protein
192 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 432-443 amino acids (not heteromeric)

P22567 amino-acid N-acetyltransferase (EC 2.3.1.1)
PFams: AA_kinase, Acetyltransf_1, Acetyltransf_7
432 amino acids: PaperBLAST, CDD, Compare to cluster

N-ACETYLTRANSFER-MONOMER N-acetylglutamate synthase (EC 2.3.1.1)
P0A6C5 Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS; NAGS; EC 2.3.1.1
CH_024150 amino-acid acetyltransferase
PFams: AA_kinase, Acetyltransf_1
443 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/9 heteromeric)

C4NFG1 amino-acid N-acetyltransferase (EC 2.3.1.1)
PFams: AA_kinase, Acetyltransf_1, Acetyltransf_7
603 amino acids: PaperBLAST, CDD

Q8NM40 amino-acid N-acetyltransferase (EC 2.3.1.1)
G18NG-12357-MONOMER L-glutamate N-acetyltransferase (EC 2.3.1.1)
PFams: Acetyltransf_1, Acetyltransf_7, Acetyltransf_10, FR47
335 amino acids: PaperBLAST, CDD

Q9I3W7 amino-acid N-acetyltransferase (EC 2.3.1.1)
PFams: Acetyltransf_3, Acetyltransf_4, Acetyltransf_1, Acetyltransf_10, Acetyltransf_7
177 amino acids: PaperBLAST, CDD

O33289 Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS; NAGS; EC 2.3.1.1
PFams: Acetyltransf_1, Acetyltransf_10, Acetyltransf_7
174 amino acids: PaperBLAST, CDD

O94330 Amino-acid acetyltransferase, mitochondrial; Arginine-requiring protein 6; Glutamate N-acetyltransferase; N-acetylglutamate synthase; AGS; NAGS; EC 2.3.1.1
PFams: NAT
500 amino acids: PaperBLAST, CDD

P40360 Amino-acid acetyltransferase, mitochondrial; Arginine-requiring protein 2; Glutamate N-acetyltransferase; N-acetylglutamate synthase; AGS; NAGS; EC 2.3.1.1
PFams: NAT
574 amino acids: PaperBLAST, CDD

G6759-MONOMER L-amino acid N-acyltransferase (EC 2.3.1.1)
P76112 L-amino acid N-acyltransferase MnaT; L-methionine N-acyltransferase; L-methionine sulfoximine/L-methionine sulfone N-acetyltransferase; L-phenylglycine N-acetyltransferase; EC 2.3.1.-
PFams: Acetyltransf_3, Acetyltransf_4, Acetyltransf_1, Acetyltransf_10, Acetyltransf_7, GNAT_acetyltran, FR47
172 amino acids: PaperBLAST, CDD

Q1K8F6 Amino-acid acetyltransferase, mitochondrial; Arginine-requiring protein 14; Glutamate N-acetyltransferase; N-acetylglutamate synthase; AGS; NAGS; EC 2.3.1.1
PFams: NAT
712 amino acids: PaperBLAST, CDD

Q59MB6 Amino-acid acetyltransferase, mitochondrial; Arginine-requiring protein 2; Glutamate N-acetyltransferase; N-acetylglutamate synthase; AGS; NAGS; EC 2.3.1.1
PFams: NAT
580 amino acids: PaperBLAST, CDD