Clusters of Characterized Proteins

Clustering the characterized proteins for argB (N-acylglutamate kinase) in L-proline biosynthesis

Or see other characterized proteins similar to argB

Or see all steps for L-proline biosynthesis

Or cluster curated proteins matching a keyword

Definition of argB

• Curated proteins or TIGRFams with EC 2.7.2.8
• Ignore hits to O67848 when looking for 'other' hits (UDP-3-O-acyl-N-acetylglucosamine deacetylase (EC 3.5.1.108))
• Comment: ArgB includes Bacteroides proteins that act on N-succinylglutamate instead of the usual N-acetylglutamate (i.e. BT3395). See "Discovery of novel pathways of microbial arginine biosynthesis" (2010), PhD thesis of Juan Manuel Cabrera Luque, which shows that argB from B. fragilis is N-succinylglutamate kinase. In the version of BRENDA we are using, lpxC from Aquifex aeolicus is erroneously given as O67848 (which is probably argB), not O67648. (This has since been corrected in BRENDA.)

Fetched 17 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 16 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 248-347 amino acids (not heteromeric)

Q9X2A4 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8
Q9X2A4 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase
282 amino acids: PaperBLAST, CDD, Compare to cluster

Q6R6P5 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase
317 amino acids: PaperBLAST, CDD, Compare to cluster

Q6V1L5 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q9HTN2 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8
Q9HTN2 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase
301 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SCL7 Acetylglutamate kinase, chloroplastic; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AtNAGK; EC 2.7.2.8
Q9SCL7 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase
347 amino acids: PaperBLAST, CDD, Compare to cluster

ACETYLGLUTKIN-MONOMER acetylglutamate kinase (EC 2.7.2.8)
P0A6C8 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8
CH_001694 acetylglutamate kinase; EC 2.7.2.8
PFams: AA_kinase
258 amino acids: PaperBLAST, CDD, Compare to cluster

O50147 [LysW]-aminoadipate kinase; EC 2.7.2.- (from HMM only)
PFams: AA_kinase
269 amino acids: PaperBLAST, CDD, Compare to cluster

P9WQ01 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8
PFams: AA_kinase
294 amino acids: PaperBLAST, CDD, Compare to cluster

Q4JAQ2 [LysW]-aminoadipate/[LysW]-glutamate kinase; EC 2.7.2.-
MONOMER-18312 [LysW}-glutamate/[LysW]-aminoadipate kinase (EC 2.7.2.8)
PFams: AA_kinase
261 amino acids: PaperBLAST, CDD, Compare to cluster

Q72HA9 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8
PFams: AA_kinase
248 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 421-447 amino acids (not heteromeric)

A0A0H2X8L7 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase, NAT
447 amino acids: PaperBLAST, CDD, Compare to cluster

Q0ASS9 amino-acid N-acetyltransferase (EC 2.3.1.1); acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase, NAT
441 amino acids: PaperBLAST, CDD, Compare to cluster

Q87EL2 amino-acid N-acetyltransferase (EC 2.3.1.1) (from HMM only)
PFams: AA_kinase, NAT
421 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 857-885 amino acids (not heteromeric)

Q01217 Protein ARG5,6, mitochondrial; EC 1.2.1.38; EC 2.7.2.8
Q01217 acetylglutamate kinase (EC 2.7.2.8)
PFams: AA_kinase, NAT, Semialdhyde_dh, Semialdhyde_dhC
863 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123299 arginine biosynthetic enzyme activities (from HMM only)
PFams: AA_kinase, NAT, Semialdhyde_dh
857 amino acids: PaperBLAST, CDD, Compare to cluster

CH_125213 N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase; EC 1.2.1.38; EC 2.7.2.8
PFams: AA_kinase, NAT, Semialdhyde_dh
885 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q8P8J7 acetylglutamate kinase (EC 2.7.2.8)
PFams: Acetyltransf_3
203 amino acids: PaperBLAST, CDD