Other Characterized Proteins Similar to argE

Finding the characterized proteins for argE (N-acetylornithine deacetylase) in L-proline biosynthesis

Or see clustering for step argE

Or see all steps for L-proline biosynthesis

Or cluster curated proteins matching a keyword

Definition of argE

• Curated proteins or TIGRFams with EC 3.5.1.16
• Curated proteins matching N-acetylcitrulline deacetylase
• Predicted: UniProt sequence W3Y6L2: SubName: Full=Amidohydrolase {ECO:0000313|EMBL:ETS93161.1};
• Comment: This EC number also includes N-acetylcitrulline deacetylase, which is part of pathway III. A putative amidohydrolase "ArgA3" (W3Y6L2) is in a conserved operon with ornithine carbamoyltransferase (the next step) in Veillonella and related genera (PMC9026213). The genome context includes other arginine synthesis genes as well. Although ArgA3 was proposed to be a N-acetylglutamate synthase, it is related to N-acetyl-cysteine deacetylase, and the genomes with "ArgA3" are lacking argE as well; so we think argE is the more likely function.

Fetched 8 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 2 other characterized sequences. (Found 9 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for argE.)

O58754 N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) from Pyrococcus horikoshii
PFams: Peptidase_M20, M20_dimer
387 amino acids: PaperBLAST, CDD, BRENDA::O58754
41% identical to

W3Y6L2 Amidohydrolase
394 amino acids: PaperBLAST, CDD

O34980 N-acetyl-L-cysteine deacetylase from Bacillus subtilis (strain 168)
SNDA_BACSU / O34980 N-acetyl-L-cysteine deacetylase; EC 3.5.1.- from Bacillus subtilis (strain 168)
PFams: Peptidase_M20, M20_dimer
416 amino acids: PaperBLAST, CDD, SwissProt::O34980
42% identical to

W3Y6L2 Amidohydrolase
394 amino acids: PaperBLAST, CDD