Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for cyclodeaminase (ornithine cyclodeaminase) in L-proline biosynthesis

Or see other characterized proteins similar to cyclodeaminase

Or see all steps for L-proline biosynthesis

Or cluster curated proteins matching a keyword

Definition of cyclodeaminase

Curated proteins or TIGRFams with EC 4.3.1.12
UniProt sequence Q6LXX7: RecName: Full=LOR/SDH bifunctional enzyme conserved domain-containing protein {ECO:0000259|Pfam:PF04455};
Comment: In many archaea, proline is formed from ornithine via a cyclodeaminase (PMID:11489875). Mls2 (Q6LXX7, MMP1218, MMP_RS06270) was identified as an ornithine cyclodeaminase (PMID:30636068), and it is important for fitness unless proline is added (Leslie Day).

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 341-356 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

OCD_PSEPK / Q88H32 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Q88H32 ornithine cyclodeaminase (EC 4.3.1.12) from Pseudomonas putida
PFams: OCD_Mu_crystall
350 amino acids: PaperBLAST, CDD, Compare to cluster

P09773 ornithine cyclodeaminase (EC 4.3.1.12) from Agrobacterium fabrum (strain C58 / ATCC 33970)
OCD_AGRFC / P09773 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
PFams: OCD_Mu_crystall
354 amino acids: PaperBLAST, CDD, Compare to cluster

OCD_AGRT4 / Q59701 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Agrobacterium tumefaciens (strain Ach5)
PFams: OCD_Mu_crystall
356 amino acids: PaperBLAST, CDD, Compare to cluster

J7SH14 ornithine cyclodeaminase subunit (EC 4.3.1.12) from Clostridium sporogenes (strain ATCC 15579)
PFams: OCD_Mu_crystall
341 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

Q6LXX7 LOR/SDH bifunctional enzyme conserved domain-containing protein {ECO:0000259|Pfam:PF04455}
415 amino acids: PaperBLAST, CDD

Q8YMD9 arginine dihydrolase/ornithine cyclodeaminase (EC 4.3.1.12) from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
PFams: DDAH_eukar, Saccharop_dh_N, ArgZ-like_C_1st, ArgZ-like_C_2nd
703 amino acids: PaperBLAST, CDD