GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for serA (3-phosphoglycerate dehydrogenase) in L-serine biosynthesis

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Definition of serA

Fetched 20 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 19 of these sequences

Found 4 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 525-624 amino acids (not heteromeric)

P9WNX3 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, ACT
528 amino acids: PaperBLAST, CDD, Compare to cluster

O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, ACT
624 amino acids: PaperBLAST, CDD, Compare to cluster

O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
533 amino acids: PaperBLAST, CDD, Compare to cluster

O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, AdoHcyase_NAD, IlvN, ACT
603 amino acids: PaperBLAST, CDD, Compare to cluster

Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
533 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LT69 D-3-phosphoglycerate dehydrogenase 3, chloroplastic; EC 1.1.1.95
Q9LT69 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, ACT
588 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, ACT
529 amino acids: PaperBLAST, CDD, Compare to cluster

CH_004924 phosphoglycerate dehydrogenase; EC 1.1.1.95
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, ACT
525 amino acids: PaperBLAST, CDD, Compare to cluster

O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95
MONOMER-10261 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
533 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 315-469 amino acids (not heteromeric)

PGLYCDEHYDROG-MONOMER phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399)
P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95)
CH_088336 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95
PFams: 2-Hacid_dh, 2-Hacid_dh_C, ACT
410 amino acids: PaperBLAST, CDD, Compare to cluster

U3RH61 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
442 amino acids: PaperBLAST, CDD, Compare to cluster

P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
469 amino acids: PaperBLAST, CDD, Compare to cluster

P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
469 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9ZCD3 3-phosphoglycerate dehydrogenase
315 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 299-333 amino acids (not heteromeric)

Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
313 amino acids: PaperBLAST, CDD, Compare to cluster

O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q76KF5 phosphoglycerate dehydrogenase (EC 1.1.1.95)
CH_000791 D-phosphoglycerate dehydrogenase; EC 1.1.1.95
PFams: 2-Hacid_dh, 2-Hacid_dh_C
299 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 1333-1364 amino acids (not heteromeric)

BFirm:BPHYT_RS03150 Phosphoglycerate dehydrogenase (EC:1.1.1.95)
PFams: DUF3683, FAD_binding_4, FAD-oxidase_C, FAD-oxidase_C, Fer4_8, CCG, CCG, DUF3400
1364 amino acids: PaperBLAST, CDD, Compare to cluster

HerbieS:HSERO_RS19500 Putative phosphoglycerate dehydrogenase (EC:1.1.1.95)
PFams: DUF3683, FAD_binding_4, FAD-oxidase_C, FAD-oxidase_C, Fer4_8, Fer4_17, CCG, CCG, DUF3400
1333 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

SB2B:6938941 Phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh_C, NAD_binding_2
308 amino acids: PaperBLAST, CDD