Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for serA (3-phosphoglycerate dehydrogenase) in L-serine biosynthesis

Or see other characterized proteins similar to serA

Or see all steps for L-serine biosynthesis

Or cluster curated proteins matching a keyword

Definition of serA

Curated proteins or TIGRFams with EC 1.1.1.95
UniProt sequence A0A1X9ZCD3: SubName: Full=3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:ARS42937.1};
Ignore hits to Q4JDI4 when looking for 'other' hits (phosphoglycerate dehydrogenase (EC 1.1.1.95))
Comment: BRENDA::Q4JDI4 is misannotated as 3-phosphoglycerate dehydrogenase instead of 3-phosphoglycerate kinase. (The curators were notified and report that they have corrected this.) CA265_RS09010 (A0A1X9ZCD3) from Pedobacter sp. GW460-11-11-14-LB5 is annotated as 3-phosphoglycerate dehydrogenase and has auxotrophic phenotypes. In particular, mutants are partially rescued by glycine or serine. Also it is adjacent to the putative serC.

Fetched 20 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 19 of these sequences

Found 4 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 525-624 amino acids (not heteromeric)

P9WNX3 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, ACT
528 amino acids: PaperBLAST, CDD, Compare to cluster

O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, ACT
624 amino acids: PaperBLAST, CDD, Compare to cluster

O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
533 amino acids: PaperBLAST, CDD, Compare to cluster

O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, AdoHcyase_NAD, IlvN, ACT
603 amino acids: PaperBLAST, CDD, Compare to cluster

Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
533 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LT69 D-3-phosphoglycerate dehydrogenase 3, chloroplastic; EC 1.1.1.95
Q9LT69 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, ACT
588 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, ACT
529 amino acids: PaperBLAST, CDD, Compare to cluster

CH_004924 phosphoglycerate dehydrogenase; EC 1.1.1.95
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, ACT
525 amino acids: PaperBLAST, CDD, Compare to cluster

O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95
MONOMER-10261 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
533 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 315-469 amino acids (not heteromeric)

PGLYCDEHYDROG-MONOMER phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399)
P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95)
CH_088336 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95
PFams: 2-Hacid_dh, 2-Hacid_dh_C, ACT
410 amino acids: PaperBLAST, CDD, Compare to cluster

U3RH61 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
442 amino acids: PaperBLAST, CDD, Compare to cluster

P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
469 amino acids: PaperBLAST, CDD, Compare to cluster

P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
469 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9ZCD3 3-phosphoglycerate dehydrogenase
315 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 299-333 amino acids (not heteromeric)

Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C
313 amino acids: PaperBLAST, CDD, Compare to cluster

O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q76KF5 phosphoglycerate dehydrogenase (EC 1.1.1.95)
CH_000791 D-phosphoglycerate dehydrogenase; EC 1.1.1.95
PFams: 2-Hacid_dh, 2-Hacid_dh_C
299 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 1333-1364 amino acids (not heteromeric)

BFirm:BPHYT_RS03150 Phosphoglycerate dehydrogenase (EC:1.1.1.95)
PFams: DUF3683, FAD_binding_4, FAD-oxidase_C, FAD-oxidase_C, Fer4_8, CCG, CCG, DUF3400
1364 amino acids: PaperBLAST, CDD, Compare to cluster

HerbieS:HSERO_RS19500 Putative phosphoglycerate dehydrogenase (EC:1.1.1.95)
PFams: DUF3683, FAD_binding_4, FAD-oxidase_C, FAD-oxidase_C, Fer4_8, Fer4_17, CCG, CCG, DUF3400
1333 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

SB2B:6938941 Phosphoglycerate dehydrogenase (EC 1.1.1.95)
PFams: 2-Hacid_dh_C, NAD_binding_2
308 amino acids: PaperBLAST, CDD