GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for serB (phosphoserine phosphatase) in L-serine biosynthesis

Or see other characterized proteins similar to serB

Or see all steps for L-serine biosynthesis

Or cluster curated proteins matching a keyword

Definition of serB

Fetched 38 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 31 of these sequences

Found 6 clusters of similar sequences. Another 10 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 206-295 amino acids (not heteromeric)

SERB_ALBFT / Q21YU0 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
PFams: Hydrolase, Put_Phosphatase, HAD, Hydrolase_3
237 amino acids: PaperBLAST, CDD, Compare to cluster

P78330 L-3-phosphoserine phosphatase (EC 3.1.3.3) from Homo sapiens
SERB_HUMAN / P78330 Phosphoserine phosphatase; PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Homo sapiens (Human)
P78330 phosphoserine phosphatase (EC 3.1.3.3) from Homo sapiens
PFams: Hydrolase, HAD, UMPH-1
225 amino acids: PaperBLAST, CDD, Compare to cluster

Q5M819 phosphoserine phosphatase (EC 3.1.3.3) from Rattus norvegicus
PFams: Hydrolase, HAD
225 amino acids: PaperBLAST, CDD, Compare to cluster

Q99LS3 phosphoserine phosphatase (EC 3.1.3.3) from Mus musculus
PFams: Hydrolase, HAD
225 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_CAMJD / A7H590 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
PFams: Hydrolase, HAD_2, HAD, Hydrolase_3
207 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_HALS3 / B0R7U7 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
PFams: Hydrolase, HAD, Hydrolase_3
211 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_POLSJ / Q12A06 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Polaromonas sp. (strain JS666 / ATCC BAA-500)
PFams: Hydrolase, Put_Phosphatase, HAD, Hydrolase_3
236 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_METJA / Q58989 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58989 phosphoserine phosphatase (EC 3.1.3.3) from Methanocaldococcus jannaschii
PFams: Hydrolase, Put_Phosphatase, HAD_2, HAD, Hydrolase_3
211 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_STRT2 / Q5M3B3 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
PFams: Hydrolase, HAD, HAD_2, Hydrolase_3
215 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_IDILO / Q5QXU4 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
PFams: Hydrolase, HAD, Hydrolase_3
220 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_WOLSU / Q7M7U5 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
PFams: Hydrolase, HAD, HAD_2, Hydrolase_3
206 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_LACLA / Q9CHW3 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
PFams: Hydrolase, HAD, HAD_2, Hydrolase_3
216 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1R2PVY2 Phosphoserine phosphatase; EC=3.1.3.3; O-phosphoserine phosphohydrolase
295 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 205-238 amino acids (not heteromeric)

PSPA_HYDTT / D3DFG8 Phosphoserine phosphatase 1; PSP 1; PSPase 1; Metal-independent phosphoserine phosphatase 1; iPSP1; O-phosphoserine phosphohydrolase 1; EC 3.1.3.3 from Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
D3DFG8 phosphoserine phosphatase (EC 3.1.3.3) from Hydrogenobacter thermophilus
PFams: His_Phos_1
211 amino acids: PaperBLAST, CDD, Compare to cluster

SERCL_ARATH / F4KI56 Metal-independent phosphoserine phosphatase; iPSP; Phosphoglycerate mutase-like protein 3; EC 3.1.3.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: His_Phos_1
238 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0H2XA29 Phosphoglycerate mutase
214 amino acids: PaperBLAST, CDD, Compare to cluster

A0A3D8VK77 Histidine phosphatase family protein
213 amino acids: PaperBLAST, CDD, Compare to cluster

N9V397 Phosphoglycerate mutase family protein, putative
205 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 309-328 amino acids (not heteromeric)

b4388 phosphoserine phosphatase (EC 3.1.3.3) from Escherichia coli K-12 substr. MG1655
P0AGB0 phosphoserine phosphatase (EC 3.1.3.3) from Escherichia coli (strain K12)
SERB_ECOLI / P0AGB0 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Escherichia coli (strain K12)
CH_024035 phosphoserine phosphatase; EC 3.1.3.3 from Escherichia coli K12
PFams: DUF5609, Hydrolase, HAD, Hydrolase_3
322 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_YEAST / P42941 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Hydrolase, HAD, Hydrolase_3
309 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_VIBCH / Q9KPM2 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
PFams: DUF5609, Hydrolase, HAD, Hydrolase_3
328 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 409-411 amino acids (not heteromeric)

SERB2_MYCTU / O53289 Phosphoserine phosphatase SerB2; PSP; PSPase; O-phosphoserine phosphohydrolase; Protein-serine/threonine phosphatase; EC 3.1.3.3; EC 3.1.3.16 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
O53289 phosphoserine phosphatase (EC 3.1.3.3) from Mycobacterium tuberculosis
PFams: ACT_6, ACT_PSP_2, Hydrolase, HAD, Hydrolase_3
409 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_MYCA1 / A0QJI1 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Mycobacterium avium (strain 104)
PFams: ACT_6, ACT_PSP_2, Hydrolase, HAD, Hydrolase_3
411 amino acids: PaperBLAST, CDD, Compare to cluster

SERB_STRCO / Q9S281 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
PFams: ACT_6, ACT_PSP_2, Hydrolase, HAD, Hydrolase_3
410 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 5 249-260 amino acids (not heteromeric)

PSP_BACSU / P94512 Phosphoserine phosphatase; PSP; EC 3.1.3.3 from Bacillus subtilis (strain 168)
PFams: Hydrolase, HAD_2, Hydrolase_like
260 amino acids: PaperBLAST, CDD, Compare to cluster

PSP_THET2 / Q72H00 Phosphoserine phosphatase; PSP; EC 3.1.3.3 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
PFams: Hydrolase, HAD_2, Hydrolase_like
249 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 6 205-237 amino acids (not heteromeric)

THRH_PSESM / Q883R9 Phosphoserine phosphatase; PSP; PSPase; EC 3.1.3.3 from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
PFams: Hydrolase, HAD
237 amino acids: PaperBLAST, CDD, Compare to cluster

THRH_PSEAE / Q9I2Y2 Phosphoserine phosphatase ThrH; PSP; PSPase; EC 3.1.3.3 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Hydrolase, HAD
205 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/10 heteromeric)

B6YX36 phosphoserine phosphatase (EC 3.1.3.3) from Thermococcus onnurineus
PFams: Hydrolase, HAD
194 amino acids: PaperBLAST, CDD
(similar to SwissProt::Q58989 from Cluster 1, but similarity to seed sequence is below thresholds)

SERC_ARATH / O82796 Phosphoserine phosphatase, chloroplastic; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Hydrolase, HAD
295 amino acids: PaperBLAST, CDD
(similar to BRENDA::P78330 from Cluster 1, but similarity to seed sequence is below thresholds)

SERB1_MYCTU / P9WGJ3 Phosphoserine phosphatase SerB1; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Hydrolase, HAD, Hydrolase_3
308 amino acids: PaperBLAST, CDD

SERB_DROME / Q9VSY6 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3 from Drosophila melanogaster (Fruit fly)
PFams: Hydrolase, HAD
270 amino acids: PaperBLAST, CDD
(similar to BRENDA::P78330 from Cluster 1, but similarity to seed sequence is below thresholds)

A0A6B4WGC7 DUF1015 domain-containing protein
440 amino acids: PaperBLAST, CDD

F9VNX9 Phosphoserine aminotransferase; EC=2.6.1.52
372 amino acids: PaperBLAST, CDD

P72649 Phosphoglycerate mutase
349 amino acids: PaperBLAST, CDD

Q9K8N3 BH2972 protein
276 amino acids: PaperBLAST, CDD

Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: HAD, 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
630 amino acids: PaperBLAST, CDD

CA265_RS22635 phosphoserine phosphatase (EC 3.1.3.3) from Pedobacter sp. GW460-11-11-14-LB5
PFams: HAD, 2-Hacid_dh
433 amino acids: PaperBLAST, CDD