Other Characterized Proteins Similar to serB
Finding the characterized proteins for serB (phosphoserine phosphatase) in L-serine biosynthesis
Or see clustering for step serB
Or see all steps for L-serine biosynthesis
Or cluster curated proteins matching a keyword
Definition of serB
- Curated proteins or TIGRFams with EC 3.1.3.3
- UniProt sequence A0A1X9ZBA8_9SPHI: RecName: Full=2-oxoglutarate reductase {ECO:0000256|ARBA:ARBA00016905}; EC=1.1.1.399 {ECO:0000256|ARBA:ARBA00013001}; EC=3.1.3.3 {ECO:0000256|ARBA:ARBA00012640}; AltName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|ARBA:ARBA00021582}; AltName: Full=O-phosphoserine phosphohydrolase {ECO:0000256|ARBA:ARBA00013466};
- UniProt sequence L0G228_ECHVK: RecName: Full=2-oxoglutarate reductase {ECO:0000256|ARBA:ARBA00016905}; EC=1.1.1.399 {ECO:0000256|ARBA:ARBA00013001}; EC=1.1.1.95 {ECO:0000256|ARBA:ARBA00013143}; EC=3.1.3.3 {ECO:0000256|ARBA:ARBA00012640}; AltName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|ARBA:ARBA00021582}; AltName: Full=O-phosphoserine phosphohydrolase {ECO:0000256|ARBA:ARBA00013466};
- Ignore hits to items matching EC 1.1.1.95 when looking for 'other' hits
- Ignore hits to P60487 when looking for 'other' hits (pyridoxal phosphatase (EC 3.1.3.74). Pyridoxal phosphate phosphatase; PLP phosphatase; Chronophin; EC 3.1.3.3; EC 3.1.3.74)
- Ignore hits to Q96GD0 when looking for 'other' hits (pyridoxal phosphatase (EC 3.1.3.74). Pyridoxal phosphate phosphatase; PLP phosphatase; Chronophin; EC 3.1.3.3; EC 3.1.3.74)
- Ignore hits to Q9P376 when looking for 'other' hits (CTD phosphatase Fcp1; EC 3.1.3.3. RNA polymerase II subunit A C-terminal domain phosphatase; CTD phosphatase fcp1; EC 3.1.3.16)
- Ignore hits to Q3ZBF9 when looking for 'other' hits (Pyridoxal phosphate phosphatase; PLP phosphatase; Chronophin; EC 3.1.3.3; EC 3.1.3.74)
- Ignore hits to P00634 when looking for 'other' hits (alkaline phosphatase (EC 3.1.3.1). alkaline phosphatase (EC 3.1.3.1; EC 3.1.3.75; EC 3.1.3.41; EC 3.1.3.74; EC 3.1.3.99; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.91; EC 3.1.3.60; EC 3.1.3.15; EC 3.1.3.102; EC 3.1.3.2; EC 3.1.3.11; EC 3.1.3.20; EC 3.1.3.19; EC 3.1.3.3; EC 3.6.1.25; EC 3.6.1.1; EC 3.1.3.58; EC 3.1.3.9; EC 3.1.3.23; EC 3.1.3.38; EC 3.1.3.18; EC 3.1.3.68; EC 3.9.1.1). alkaline phosphatase (EC 3.1.3.1; EC 3.1.3.75; EC 3.1.3.41; EC 3.1.3.74; EC 3.1.3.99; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.91; EC 3.1.3.60; EC 3.1.3.15; EC 3.1.3.102; EC 3.1.3.2; EC 3.1.3.11; EC 3.1.3.20; EC 3.1.3.19; EC 3.1.3.3; EC 3.6.1.25; EC 3.6.1.1; EC 3.1.3.58; EC 3.1.3.23; EC 3.1.3.38; EC 3.1.3.18; EC 3.1.3.68; EC 3.9.1.1))
- Ignore hits to P0AE22 when looking for 'other' hits (acid phosphatase (EC 3.1.3.2). class B acid phosphatase; EC 3.1.3.2. Class B acid phosphatase; CBAP; EC 3.1.3.2. acid phosphatase / phosphotransferase (EC 3.1.3.2; EC 3.1.3.31; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.34; EC 3.1.3.3). acid phosphatase / phosphotransferase (EC 3.1.3.2; EC 3.1.3.31; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.34; EC 3.1.3.3))
- Ignore hits to Q9P376 when looking for 'other' hits (CTD phosphatase Fcp1; EC 3.1.3.3. RNA polymerase II subunit A C-terminal domain phosphatase; CTD phosphatase fcp1; EC 3.1.3.16)
- Ignore hits to P17906 when looking for 'other' hits (Phosphoserine phosphatase RsbX; Sigma-B negative effector; EC 3.1.3.3)
- Ignore hits to P40399 when looking for 'other' hits (Phosphoserine phosphatase RsbU; Sigma factor SigB regulation protein RsbU; EC 3.1.3.3)
- Ignore hits to P94526 when looking for 'other' hits (Sugar-phosphatase AraL; Arabinose operon protein AraL; Phosphoserine phosphatase; EC 3.1.3.23; EC 3.1.3.3)
- UniProt sequence Q9K8N3: SubName: Full=BH2972 protein {ECO:0000313|EMBL:BAB06691.1};
- UniProt sequence A0A1R2PVY2: RecName: Full=O-phosphoserine phosphohydrolase {ECO:0000256|ARBA:ARBA00013466}; EC=3.1.3.3 {ECO:0000256|ARBA:ARBA00012640}; AltName: Full=Phosphoserine phosphatase {ECO:0000256|ARBA:ARBA00015196};
- Comment: CA265_RS22635 (A0A1X9ZBA8_9SPHI) is diverged serB and is auxotrophic. It also appears to be fused to diverged serA, but there is another serA in the genome (CA265_RS09010), so CA265_RS22635 may not be a functional dehydrogenase. Echvi_2777 (L0G228_ECHVK) from Echinicola vietnamensis KMM 6221 is a diverged serB and is auxotrophic, rescued by serine. It is fused to serA and probably provides that activity as well. Hits to serA are ignored because of serAB fusions. Some curated resources link this EC number to protein phosphatases, or to non-specific periplasmic phosphatases, that are unlikely to play a role in serine biosynthesis. These are all marked ignore (P60487, Q96GD0, Q3ZBF9, P00634, P0AE22, Q9P376). Also, Swiss-Prot annotates RsbX (P17906) and RsbU (P40399) with this EC number, but they probably act on proteins. I was not able to find evidence that AraL (P94526) is a phosphoserine phosphatase (the cited paper PMID:25848029 does not seem to discuss this protein.) PMID:25848029 does show that Q9K8N3 and X3MFA4 (A0A1R2PVY2) have this activity.
Fetched 31 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 1 other characterized sequences. (Found 28 hits including self hits.)
Close sequences
(Sequences that are similar to these will not be high-confidence candidates for serB.)
C5H3W1 glycerol-3-phosphate dehydrogenase (NAD+) (EC 1.1.1.8)
PFams: HAD, Hydrolase, NAD_Gly3P_dh_N, NAD_Gly3P_dh_C
701 amino acids: PaperBLAST, CDD, BRENDA::C5H3W1
40% identical to
Q5M819 phosphoserine phosphatase (EC 3.1.3.3)
PFams: Hydrolase, HAD
225 amino acids: PaperBLAST, CDD