Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for serB (phosphoserine phosphatase) in L-serine biosynthesis

Or see other characterized proteins similar to serB

Or see all steps for L-serine biosynthesis

Or cluster curated proteins matching a keyword

Definition of serB

Curated proteins or TIGRFams with EC 3.1.3.3
UniProt sequence A0A1X9ZBA8_9SPHI: RecName: Full=2-oxoglutarate reductase {ECO:0000256|ARBA:ARBA00016905}; EC=1.1.1.399 {ECO:0000256|ARBA:ARBA00013001}; EC=3.1.3.3 {ECO:0000256|ARBA:ARBA00012640}; AltName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|ARBA:ARBA00021582}; AltName: Full=O-phosphoserine phosphohydrolase {ECO:0000256|ARBA:ARBA00013466};
UniProt sequence L0G228_ECHVK: RecName: Full=2-oxoglutarate reductase {ECO:0000256|ARBA:ARBA00016905}; EC=1.1.1.399 {ECO:0000256|ARBA:ARBA00013001}; EC=1.1.1.95 {ECO:0000256|ARBA:ARBA00013143}; EC=3.1.3.3 {ECO:0000256|ARBA:ARBA00012640}; AltName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|ARBA:ARBA00021582}; AltName: Full=O-phosphoserine phosphohydrolase {ECO:0000256|ARBA:ARBA00013466};
Ignore hits to items matching EC 1.1.1.95 when looking for 'other' hits
Ignore hits to P60487 when looking for 'other' hits (pyridoxal phosphatase (EC 3.1.3.74). Pyridoxal phosphate phosphatase; PLP phosphatase; Chronophin; EC 3.1.3.3; EC 3.1.3.74)
Ignore hits to Q96GD0 when looking for 'other' hits (pyridoxal phosphatase (EC 3.1.3.74). Pyridoxal phosphate phosphatase; PLP phosphatase; Chronophin; EC 3.1.3.3; EC 3.1.3.74)
Ignore hits to Q9P376 when looking for 'other' hits (CTD phosphatase Fcp1; EC 3.1.3.3. RNA polymerase II subunit A C-terminal domain phosphatase; CTD phosphatase fcp1; EC 3.1.3.16)
Ignore hits to Q3ZBF9 when looking for 'other' hits (Pyridoxal phosphate phosphatase; PLP phosphatase; Chronophin; EC 3.1.3.3; EC 3.1.3.74)
Ignore hits to P00634 when looking for 'other' hits (alkaline phosphatase (EC 3.1.3.1). alkaline phosphatase (EC 3.1.3.1; EC 3.1.3.75; EC 3.1.3.41; EC 3.1.3.74; EC 3.1.3.99; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.91; EC 3.1.3.60; EC 3.1.3.15; EC 3.1.3.102; EC 3.1.3.2; EC 3.1.3.11; EC 3.1.3.20; EC 3.1.3.19; EC 3.1.3.3; EC 3.6.1.25; EC 3.6.1.1; EC 3.1.3.58; EC 3.1.3.9; EC 3.1.3.23; EC 3.1.3.38; EC 3.1.3.18; EC 3.1.3.68; EC 3.9.1.1). alkaline phosphatase (EC 3.1.3.1; EC 3.1.3.75; EC 3.1.3.41; EC 3.1.3.74; EC 3.1.3.99; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.91; EC 3.1.3.60; EC 3.1.3.15; EC 3.1.3.102; EC 3.1.3.2; EC 3.1.3.11; EC 3.1.3.20; EC 3.1.3.19; EC 3.1.3.3; EC 3.6.1.25; EC 3.6.1.1; EC 3.1.3.58; EC 3.1.3.23; EC 3.1.3.38; EC 3.1.3.18; EC 3.1.3.68; EC 3.9.1.1))
Ignore hits to P0AE22 when looking for 'other' hits (acid phosphatase (EC 3.1.3.2). class B acid phosphatase; EC 3.1.3.2. Class B acid phosphatase; CBAP; EC 3.1.3.2. acid phosphatase / phosphotransferase (EC 3.1.3.2; EC 3.1.3.31; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.34; EC 3.1.3.3). acid phosphatase / phosphotransferase (EC 3.1.3.2; EC 3.1.3.31; EC 3.1.3.5; EC 3.1.3.6; EC 3.1.3.89; EC 3.1.3.34; EC 3.1.3.3))
Ignore hits to Q9P376 when looking for 'other' hits (CTD phosphatase Fcp1; EC 3.1.3.3. RNA polymerase II subunit A C-terminal domain phosphatase; CTD phosphatase fcp1; EC 3.1.3.16)
Ignore hits to P17906 when looking for 'other' hits (Phosphoserine phosphatase RsbX; Sigma-B negative effector; EC 3.1.3.3)
Ignore hits to P40399 when looking for 'other' hits (Phosphoserine phosphatase RsbU; Sigma factor SigB regulation protein RsbU; EC 3.1.3.3)
Ignore hits to P94526 when looking for 'other' hits (Sugar-phosphatase AraL; Arabinose operon protein AraL; Phosphoserine phosphatase; EC 3.1.3.23; EC 3.1.3.3)
UniProt sequence Q9K8N3: SubName: Full=BH2972 protein {ECO:0000313|EMBL:BAB06691.1};
UniProt sequence A0A1R2PVY2: RecName: Full=O-phosphoserine phosphohydrolase {ECO:0000256|ARBA:ARBA00013466}; EC=3.1.3.3 {ECO:0000256|ARBA:ARBA00012640}; AltName: Full=Phosphoserine phosphatase {ECO:0000256|ARBA:ARBA00015196};
Comment: CA265_RS22635 (A0A1X9ZBA8_9SPHI) is diverged serB and is auxotrophic. It also appears to be fused to diverged serA, but there is another serA in the genome (CA265_RS09010), so CA265_RS22635 may not be a functional dehydrogenase. Echvi_2777 (L0G228_ECHVK) from Echinicola vietnamensis KMM 6221 is a diverged serB and is auxotrophic, rescued by serine. It is fused to serA and probably provides that activity as well. Hits to serA are ignored because of serAB fusions. Some curated resources link this EC number to protein phosphatases, or to non-specific periplasmic phosphatases, that are unlikely to play a role in serine biosynthesis. These are all marked ignore (P60487, Q96GD0, Q3ZBF9, P00634, P0AE22, Q9P376). Also, Swiss-Prot annotates RsbX (P17906) and RsbU (P40399) with this EC number, but they probably act on proteins. I was not able to find evidence that AraL (P94526) is a phosphoserine phosphatase (the cited paper PMID:25848029 does not seem to discuss this protein.) PMID:25848029 does show that Q9K8N3 and X3MFA4 (A0A1R2PVY2) have this activity.

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 27 of these sequences

Found 5 clusters of similar sequences. Another 7 sequences are not clustered. Download as table or as draft rules or view by cluster

Organism unknown

B6YX36 phosphoserine phosphatase (EC 3.1.3.3)
PFams: Hydrolase, HAD
194 amino acids: PaperBLAST, CDD (Cluster 1)

D3DFG8 Phosphoserine phosphatase 1; PSP 1; PSPase 1; Metal-independent phosphoserine phosphatase 1; iPSP1; O-phosphoserine phosphohydrolase 1; EC 3.1.3.3
D3DFG8 phosphoserine phosphatase (EC 3.1.3.3)
PFams: His_Phos_1
211 amino acids: PaperBLAST, CDD (Cluster 3)

D3DFP8 Putative phosphoserine phosphatase 2; PSP 2; PSPase 2; Metal-independent phosphoserine phosphatase 2; iPSP2; O-phosphoserine phosphohydrolase 2; EC 3.1.3.3
D3DFP8 phosphoserine phosphatase (EC 3.1.3.3)
PFams: His_Phos_1
Heteromeric, 203 amino acids: PaperBLAST, CDD (Cluster 3)

O53289 Phosphoserine phosphatase SerB2; PSP; PSPase; O-phosphoserine phosphohydrolase; Protein-serine/threonine phosphatase; EC 3.1.3.3; EC 3.1.3.16
O53289 phosphoserine phosphatase (EC 3.1.3.3)
PFams: ACT_6, Hydrolase, HAD, S6PP, Hydrolase_3
409 amino acids: PaperBLAST, CDD (Cluster 4)

Q58989 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
Q58989 phosphoserine phosphatase (EC 3.1.3.3)
PFams: Hydrolase, Put_Phosphatase, HAD_2, HAD, Hydrolase_3
211 amino acids: PaperBLAST, CDD (Cluster 1)

Q5M819 phosphoserine phosphatase (EC 3.1.3.3)
PFams: Hydrolase, HAD
225 amino acids: PaperBLAST, CDD (Cluster 1)

Q99LS3 phosphoserine phosphatase (EC 3.1.3.3)
PFams: Hydrolase, HAD
225 amino acids: PaperBLAST, CDD (Cluster 1)

PSERPHOSPHA-MONOMER phosphoserine phosphatase (EC 3.1.3.3)
P0AGB0 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PSERPHOSPHA-MONOMER phosphoserine phosphatase (EC 3.1.3.3)
CH_024035 phosphoserine phosphatase; EC 3.1.3.3
PFams: DUF5609, Hydrolase, HAD, Hydrolase_3
322 amino acids: PaperBLAST, CDD (Cluster 2)

A0QJI1 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: ACT_6, Hydrolase, HAD, S6PP, Hydrolase_3
411 amino acids: PaperBLAST, CDD (Cluster 4)

A7H590 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, Put_Phosphatase, HAD_2, HAD, Hydrolase_3
207 amino acids: PaperBLAST, CDD (Cluster 1)

B0R7U7 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD, Hydrolase_3
211 amino acids: PaperBLAST, CDD (Cluster 1)

F4KI56 Metal-independent phosphoserine phosphatase; iPSP; Phosphoglycerate mutase-like protein 3; EC 3.1.3.3
PFams: His_Phos_1
238 amino acids: PaperBLAST, CDD (Cluster 3)

O82796 Phosphoserine phosphatase, chloroplastic; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD
295 amino acids: PaperBLAST, CDD (Singleton 1)

P42941 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, Put_Phosphatase, HAD, Hydrolase_3
309 amino acids: PaperBLAST, CDD (Cluster 2)

P78330 Phosphoserine phosphatase; PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD, UMPH-1
225 amino acids: PaperBLAST, CDD (Cluster 1)

P9WGJ3 Phosphoserine phosphatase SerB1; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD, Hydrolase_3
308 amino acids: PaperBLAST, CDD (Singleton 2)

Q12A06 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, Put_Phosphatase, HAD, Hydrolase_3
236 amino acids: PaperBLAST, CDD (Cluster 1)

Q21YU0 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, Put_Phosphatase, HAD, Hydrolase_3
237 amino acids: PaperBLAST, CDD (Cluster 1)

Q5M3B3 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD, Hydrolase_3
215 amino acids: PaperBLAST, CDD (Cluster 1)

Q5QXU4 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD, S6PP, Hydrolase_3
220 amino acids: PaperBLAST, CDD (Cluster 1)

Q7M7U5 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD, HAD_2, Hydrolase_3
206 amino acids: PaperBLAST, CDD (Cluster 1)

Q883R9 Phosphoserine phosphatase; PSP; PSPase; EC 3.1.3.3
PFams: Hydrolase, HAD
237 amino acids: PaperBLAST, CDD (Cluster 5)

Q9CHW3 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD, HAD_2, Hydrolase_3
216 amino acids: PaperBLAST, CDD (Cluster 1)

Q9I2Y2 Phosphoserine phosphatase ThrH; PSP; PSPase; EC 3.1.3.3
PFams: Hydrolase, HAD
205 amino acids: PaperBLAST, CDD (Cluster 5)

Q9KPM2 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: DUF5609, Hydrolase, HAD, Hydrolase_3
328 amino acids: PaperBLAST, CDD (Cluster 2)

Q9S281 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: ACT_6, Hydrolase, HAD, Hydrolase_3
410 amino acids: PaperBLAST, CDD (Cluster 4)

Q9VSY6 Phosphoserine phosphatase; PSP; PSPase; O-phosphoserine phosphohydrolase; EC 3.1.3.3
PFams: Hydrolase, HAD
270 amino acids: PaperBLAST, CDD (Singleton 3)

A0A1R2PVY2 O-phosphoserine phosphohydrolase; EC=3.1.3.3; Phosphoserine phosphatase
295 amino acids: PaperBLAST, CDD (Singleton 4)

A0A1X9ZBA8_9SPHI 2-oxoglutarate reductase; EC=1.1.1.399; EC=3.1.3.3; D-3-phosphoglycerate dehydrogenase; AltName: Full=O-phosphoserine phosphohydrolase
433 amino acids: PaperBLAST, CDD (Singleton 5)

L0G228_ECHVK 2-oxoglutarate reductase; EC=1.1.1.399; EC=1.1.1.95; EC=3.1.3.3; D-3-phosphoglycerate dehydrogenase; AltName: Full=O-phosphoserine phosphohydrolase
630 amino acids: PaperBLAST, CDD (Singleton 6)

Q9K8N3 BH2972 protein
276 amino acids: PaperBLAST, CDD (Singleton 7)