Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for asp-kinase (aspartate kinase) in L-threonine biosynthesis

Or see other characterized proteins similar to asp-kinase

Or see all steps for L-threonine biosynthesis

Or cluster curated proteins matching a keyword

Definition of asp-kinase

Curated proteins or TIGRFams with EC 2.7.2.4
Ignore hits to O63067 when looking for 'other' hits (homoserine dehydrogenase (EC 1.1.1.3))
Comment: For BRENDA::O63067 -- the paper describes a monofunctional hom but the sequence of O63067 is much longer and has a close homolog of functional aspartate kinase (due to alternative splicing?)

Fetched 29 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 27 of these sequences

Found 3 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 404-600 amino acids (not heteromeric)

Q57991 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT_7, ACT, ACT_7, ACT
473 amino acids: PaperBLAST, CDD, Compare to cluster

O23653 Aspartokinase 2, chloroplastic; Aspartate kinase 2; EC 2.7.2.4
O23653 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase
544 amino acids: PaperBLAST, CDD, Compare to cluster

P08495 Aspartokinase 2; Aspartate kinase 2; Aspartokinase II; EC 2.7.2.4
P08495 aspartate kinase (EC 2.7.2.4)
CH_090825 aspartate kinase 2; EC 2.7.2.4
PFams: AA_kinase, ACT, ACT_7
408 amino acids: PaperBLAST, CDD, Compare to cluster

ASPKINIII-MONOMER aspartate kinase III (EC 2.7.2.4)
P08660 Lysine-sensitive aspartokinase 3; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III; EC 2.7.2.4
P08660 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT
449 amino acids: PaperBLAST, CDD, Compare to cluster

P10869 Aspartokinase; Aspartate kinase; EC 2.7.2.4
P10869 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT_7
527 amino acids: PaperBLAST, CDD, Compare to cluster

P26512 Aspartokinase; Aspartate kinase; EC 2.7.2.4
P26512 aspartate kinase (EC 2.7.2.4)
CH_091815 aspartate kinase 2; EC 2.7.2.4
PFams: AA_kinase, ACT, ACT_7
421 amino acids: PaperBLAST, CDD, Compare to cluster

P61489 Aspartokinase; Aspartate kinase; AK; ASK; Threonine-sensitive AK; ThrA; EC 2.7.2.4
P61489 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT, ACT_7
405 amino acids: PaperBLAST, CDD, Compare to cluster

P74569 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT, ACT_7, ACT, ACT, ACT_7
600 amino acids: PaperBLAST, CDD, Compare to cluster

P9WPX3 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4
P9WPX3 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT, ACT_7
421 amino acids: PaperBLAST, CDD, Compare to cluster

Q97MC0 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT
437 amino acids: PaperBLAST, CDD, Compare to cluster

Q9LYU8 Aspartokinase 1, chloroplastic; Aspartate kinase 1; EC 2.7.2.4
Q9LYU8 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase
569 amino acids: PaperBLAST, CDD, Compare to cluster

Q9RUL9 aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase, ACT_7
473 amino acids: PaperBLAST, CDD, Compare to cluster

Q9S702 Aspartokinase 3, chloroplastic; Aspartate kinase 3; EC 2.7.2.4
Q9S702 aspartate kinase (EC 2.7.2.4)
AT3G02020-MONOMER aspartate kinase (EC 2.7.2.4)
PFams: AA_kinase
559 amino acids: PaperBLAST, CDD, Compare to cluster

CH_090816 aspartate kinase 1; EC 2.7.2.4
PFams: AA_kinase, ACT_7
404 amino acids: PaperBLAST, CDD, Compare to cluster

P41398 Aspartokinase; Aspartate kinase; EC 2.7.2.4
CH_091816 aspartate kinase; EC 2.7.2.4
PFams: AA_kinase, ACT, ACT_7
421 amino acids: PaperBLAST, CDD, Compare to cluster

A4VJB4 Aspartate kinase Ask_LysC; Aspartokinase; EC 2.7.2.4
PFams: AA_kinase, ACT, ACT_7, ACT
412 amino acids: PaperBLAST, CDD, Compare to cluster

C3JXY0 Aspartate kinase; Aspartokinase; EC 2.7.2.4
PFams: AA_kinase, ACT, ACT_7
413 amino acids: PaperBLAST, CDD, Compare to cluster

P61488 Aspartokinase; Aspartate kinase; ASK; EC 2.7.2.4
PFams: AA_kinase, ACT, ACT_7
405 amino acids: PaperBLAST, CDD, Compare to cluster

Q88EI9 Aspartate kinase; Aspartokinase; EC 2.7.2.4
PFams: AA_kinase, ACT, ACT_7
411 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 810-916 amino acids (not heteromeric)

O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3
PFams: AA_kinase, ACT, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3
PFams: AA_kinase, ACT_7, ACT, ACT_7, ACT, NAD_binding_3, Homoserine_dh
911 amino acids: PaperBLAST, CDD, Compare to cluster

ASPKINIHOMOSERDEHYDROGI-MONOMER fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3)
PFams: AA_kinase, ACT_7, ACT, ACT_7, ACT, NAD_binding_3, Homoserine_dh
820 amino acids: PaperBLAST, CDD, Compare to cluster

ASPKINIIHOMOSERDEHYDROGII-MONOMER fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3)
PFams: AA_kinase, NAD_binding_3, Homoserine_dh
810 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 510-542 amino acids (not heteromeric)

A0A0D2YG09 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4
PFams: YCII, AA_kinase, ACT_7
542 amino acids: PaperBLAST, CDD, Compare to cluster

S0DVT6 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4
PFams: AA_kinase, ACT_7
510 amino acids: PaperBLAST, CDD, Compare to cluster

W7MS01 Aspartate kinase FUB3; Fusaric acid biosynthesis protein 3; EC 2.7.2.4
PFams: AA_kinase, ACT_7
510 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

Q46133 aspartate kinase (EC 2.7.2.4)
PFams: ACT, ACT_7
172 amino acids: PaperBLAST, CDD

A4VFY3 Aspartate kinase Ask_Ect; Aspartokinase; EC 2.7.2.4
PFams: AA_kinase, ACT_7, ACT
476 amino acids: PaperBLAST, CDD

P94417 Aspartokinase 3; Aspartate kinase 3; Aspartokinase III; EC 2.7.2.4
MONOMER-6563 aspartate kinase III (EC 2.7.2.4)
PFams: AA_kinase, ACT_7
454 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q97MC0 from Cluster 1, but similarity to seed sequence is below thresholds)