GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for hom (homoserine dehydrogenase) in L-threonine biosynthesis

Or see other characterized proteins similar to hom

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Definition of hom

Fetched 21 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 21 of these sequences

Found 3 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 413-445 amino acids (not heteromeric)

P08499 Homoserine dehydrogenase; HDH; EC 1.1.1.3
P08499 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh, ACT
445 amino acids: PaperBLAST, CDD, Compare to cluster

D8WXQ1 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh, ACT
432 amino acids: PaperBLAST, CDD, Compare to cluster

D8WXQ2 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh
413 amino acids: PaperBLAST, CDD, Compare to cluster

P46806 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh, ACT
441 amino acids: PaperBLAST, CDD, Compare to cluster

Q56R01 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh, ACT
433 amino acids: PaperBLAST, CDD, Compare to cluster

P19582 Homoserine dehydrogenase; HDH; EC 1.1.1.3
PFams: NAD_binding_3, Homoserine_dh, ACT
433 amino acids: PaperBLAST, CDD, Compare to cluster

P52985 Homoserine dehydrogenase; HDH; EC 1.1.1.3
PFams: NAD_binding_3, Homoserine_dh
428 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1L6J6Q3 Homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013376, ECO:0000256|RuleBase:RU000579}; EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}
430 amino acids: PaperBLAST, CDD, Compare to cluster

B8DRS3_DESVM Homoserine dehydrogenase {ECO:0000256|ARBA:ARBA00013376, ECO:0000256|RuleBase:RU000579}; EC=1.1.1.3 {ECO:0000256|ARBA:ARBA00013213, ECO:0000256|RuleBase:RU000579}
436 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 810-916 amino acids (not heteromeric)

O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3
PFams: AA_kinase, ACT, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD, Compare to cluster

O63067 homoserine dehydrogenase (EC 1.1.1.3)
PFams: AA_kinase, ACT, ACT_7, ACT, NAD_binding_3, Homoserine_dh
916 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SA18 Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic; AK-HD 1; AK-HSDH 1; Beta-aspartyl phosphate homoserine 1; EC 2.7.2.4; EC 1.1.1.3
PFams: AA_kinase, ACT_7, ACT, ACT_7, ACT, NAD_binding_3, Homoserine_dh
911 amino acids: PaperBLAST, CDD, Compare to cluster

Q8A541_BACTN Aspartokinase; EC=1.1.1.3; EC=2.7.2.4; Homoserine dehydrogenase
811 amino acids: PaperBLAST, CDD, Compare to cluster

ASPKINIHOMOSERDEHYDROGI-MONOMER fused aspartate kinase/homoserine dehydrogenase 1 (EC 2.7.2.4; EC 1.1.1.3)
PFams: AA_kinase, ACT_7, ACT, ACT_7, ACT, NAD_binding_3, Homoserine_dh
820 amino acids: PaperBLAST, CDD, Compare to cluster

ASPKINIIHOMOSERDEHYDROGII-MONOMER fused aspartate kinase/homoserine dehydrogenase 2 (EC 2.7.2.4; EC 1.1.1.3)
PFams: AA_kinase, NAD_binding_3, Homoserine_dh
810 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 359-376 amino acids (not heteromeric)

Q5AIA2 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh
359 amino acids: PaperBLAST, CDD, Compare to cluster

Q3S3F6 homoserine dehydrogenase (EC 1.1.1.3)
PFams: Homoserine_dh
376 amino acids: PaperBLAST, CDD, Compare to cluster

Q5B998 Homoserine dehydrogenase; HDH; EC 1.1.1.3
CH_122339 homoserine dehydrogenase; EC 1.1.1.3
PFams: NAD_binding_3, Homoserine_dh
368 amino acids: PaperBLAST, CDD, Compare to cluster

P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3
PFams: NAD_binding_3, Homoserine_dh
359 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

A0A0H2WVX4 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh
426 amino acids: PaperBLAST, CDD
(similar to BRENDA::D8WXQ2 from Cluster 1, but similarity to seed sequence is below thresholds)

O58802 homoserine dehydrogenase (EC 1.1.1.3)
PFams: NAD_binding_3, Homoserine_dh
319 amino acids: PaperBLAST, CDD
(similar to BRENDA::D8WXQ2 from Cluster 1, but similarity to seed sequence is below thresholds)