Other Characterized Proteins Similar to homK

Finding the characterized proteins for homK (putative homoserine phosphotransferase) in L-threonine biosynthesis

Or see clustering for step homK

Or see all steps for L-threonine biosynthesis

Or cluster curated proteins matching a keyword

Definition of homK

• UniProt sequence Q8PX04: RecName: Full=2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Short=BPG-independent PGAM; Short=Phosphoglyceromutase; Short=aPGAM; EC=5.4.2.12;
• Comment: BT2402 (Q8PX04) is required for threonine synthesis (PMC7311316) and belongs to a family (TIGR02535) that was proposed replace the missing homoserine kinase. This family is also known as ThrB2 (PMC9026213). Homologs from Phocaeicola are also required for threonine synthesis (Surya Tripathi, personal communication). The HomK family is often encoded next to aspartate kinase and threonine synthase. It is related to phosphoglycerate mutases and might transfer phosphate groups from a donor such as phosphoenolpyruvate to homoserine. In GapMind, HomK is described separately from ThrB because it probably carries out a different reaction.

Fetched 1 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 1 other characterized sequences. (Found 1 hits including self hits.)

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for homK.)

A0A1D3TXG7 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) (EC 5.4.2.11) from Anaerobium acetethylicum
PFams: Metalloenzyme, PhosphMutase
402 amino acids: PaperBLAST, CDD, BRENDA::A0A1D3TXG7
47% identical to

Q8PX04 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Short=BPG-independent PGAM; Short=Phosphoglyceromutase; Short=aPGAM; EC=5.4.2.12
397 amino acids: PaperBLAST, CDD