GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for thrB (homoserine kinase) in L-threonine biosynthesis

Or see other characterized proteins similar to thrB

Or see all steps for L-threonine biosynthesis

Or cluster curated proteins matching a keyword

Definition of thrB

Fetched 14 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 13 of these sequences

Found 2 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 301-370 amino acids (not heteromeric)

Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana
KHSE_ARATH / Q8L7R2 Homoserine kinase; Protein DOWNY MILDEW RESISTANT 1; EC 2.7.1.39 from Arabidopsis thaliana (Mouse-ear cress)
Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana
PFams: GHMP_kinases_N, GHMP_kinases_C
370 amino acids: PaperBLAST, CDD, Compare to cluster

P07128 homoserine kinase (EC 2.7.1.39) from Corynebacterium glutamicum
PFams: GHMP_kinases_N, GHMP_kinases_C
309 amino acids: PaperBLAST, CDD, Compare to cluster

Q4Q6Y2 homoserine kinase (EC 2.7.1.39) from Leishmania major
PFams: GHMP_kinases_N, GHMP_kinases_C
341 amino acids: PaperBLAST, CDD, Compare to cluster

b0003 homoserine kinase (EC 2.7.1.39) from Escherichia coli K-12 substr. MG1655
P00547 homoserine kinase (EC 2.7.1.39) from Escherichia coli (strain K12)
KHSE_ECOLI / P00547 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Escherichia coli (strain K12)
GB|BAB96580.2 homoserine kinase; EC 2.7.1.39 from Escherichia coli
PFams: GHMP_kinases_N, GHMP_kinases_C
310 amino acids: PaperBLAST, CDD, Compare to cluster

KHSE_METMP / Q6M0H5 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Methanococcus maripaludis (strain S2 / LL)
PFams: GHMP_kinases_N, GHMP_kinases_C
301 amino acids: PaperBLAST, CDD, Compare to cluster

P04948 Homoserine kinase; Short=HK; Short=HSK; EC=2.7.1.39
309 amino acids: PaperBLAST, CDD, Compare to cluster

Echvi_2001 homoserine kinase (EC 2.7.1.39) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: GHMP_kinases_N, GHMP_kinases_C
311 amino acids: PaperBLAST, CDD, Compare to cluster

N515DRAFT_0576 homoserine kinase (EC 2.7.1.39) from Dyella japonica UNC79MFTsu3.2
PFams: GHMP_kinases_N, GHMP_kinases_C
330 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS23470 homoserine kinase (EC 2.7.1.39) from Pedobacter sp. GW460-11-11-14-LB5
PFams: GHMP_kinases_N, GHMP_kinases_C
310 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 316-319 amino acids (not heteromeric)

KHSE_PSEAE / P29364 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: APH
316 amino acids: PaperBLAST, CDD, Compare to cluster

Ga0059261_3253 homoserine kinase (EC 2.7.1.39) from Sphingomonas koreensis DSMZ 15582
PFams: APH
319 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

KHSE_YEAST / P17423 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: GHMP_kinases_N, GHMP_kinases_C
357 amino acids: PaperBLAST, CDD
(similar to BRENDA::P07128 from Cluster 1, but similarity to seed sequence is below thresholds)

Q58504 homoserine kinase monomer (EC 2.7.1.39) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
PFams: GHMP_kinases_N, GHMP_kinases_C
296 amino acids: PaperBLAST, CDD
(similar to CharProtDB::CH_002113 from Cluster 1, but similarity to seed sequence is below thresholds)

DvMF_0971 Homoserine kinase (EC:2.7.1.39) from Desulfovibrio vulgaris Miyazaki F
B8DPL9 homoserine kinase (EC 2.7.1.39) from Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F)
PFams: SKI
185 amino acids: PaperBLAST, CDD