Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for IGPS (indole-3-glycerol phosphate synthase) in L-tryptophan biosynthesis

Or see other characterized proteins similar to IGPS

Or see all steps for L-tryptophan biosynthesis

Or cluster curated proteins matching a keyword

Definition of IGPS

Curated proteins or TIGRFams with EC 4.1.1.48
UniProt sequence E4PQZ8_MARAH: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|ARBA:ARBA00018080, ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362, ECO:0000256|HAMAP-Rule:MF_00134};
UniProt sequence B8DM44_DESVM: RecName: Full=Indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362}; EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
UniProt sequence TRPC_BACTN: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
UniProt sequence G8AL05_AZOBR: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|HAMAP-Rule:MF_00134};
UniProt sequence A0A166NT80_PSEFL: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|ARBA:ARBA00018080, ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362, ECO:0000256|HAMAP-Rule:MF_00134};
UniProt sequence A0A166NT80_PSEFL: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|ARBA:ARBA00018080, ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362, ECO:0000256|HAMAP-Rule:MF_00134};
Ignore hits to items matching EC 4.1.3.27 when looking for 'other' hits
Ignore hits to P24920 when looking for 'other' hits (phosphoribosylanthranilate isomerase (EC 5.3.1.24))
Comment: Sometimes fused to anthranilate synthase subunits or known as trpC (if fused to PRAI). Ignore BRENDA::P24920 because annotated as phosphoribosylanthranilate isomerase but is also believed to be IGPS. And based on presence in Trp clusters and auxotrophic or cofit phenotypes, annotate somewhat diverged IGPS: HP15_3291 (E4PQZ8_MARAH), DvMF_1743 (B8DM44_DESVM), BT0529 (TRPC_BACTN), AZOBR_RS07450 (G8AL05_AZOBR), Pf1N1B4_2549 (A0A166NT80_PSEFL), AO353_07210 (A0A0N9WG05_PSEFL).

Fetched 13 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 9 of these sequences

Found 1 clusters of similar sequences. Another 4 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 227-278 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

Q9YGB5 indole-3-glycerol-phosphate synthase (EC 4.1.1.48)
MONOMER-3581 indole-3-glycerol phosphate synthase (EC 4.1.1.48)
PFams: IGPS
227 amino acids: PaperBLAST, CDD, Compare to cluster

A1KJ27 indole-3-glycerol-phosphate synthase (EC 4.1.1.48)
A5U2W7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48)
P9WFX7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48)
PFams: IGPS
272 amino acids: PaperBLAST, CDD, Compare to cluster

P84126 indole-3-glycerol-phosphate synthase (EC 4.1.1.48)
PFams: IGPS
254 amino acids: PaperBLAST, CDD, Compare to cluster

Q06121 indole-3-glycerol-phosphate synthase (EC 4.1.1.48)
PFams: IGPS
248 amino acids: PaperBLAST, CDD, Compare to cluster

A0A166NT80_PSEFL Indole-3-glycerol phosphate synthase {ECO:0000256|ARBA:ARBA00018080, ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362, ECO:0000256|HAMAP-Rule:MF_00134}
278 amino acids: PaperBLAST, CDD, Compare to cluster

E4PQZ8_MARAH Indole-3-glycerol phosphate synthase {ECO:0000256|ARBA:ARBA00018080, ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362, ECO:0000256|HAMAP-Rule:MF_00134}
273 amino acids: PaperBLAST, CDD, Compare to cluster

G8AL05_AZOBR Indole-3-glycerol phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|HAMAP-Rule:MF_00134}
262 amino acids: PaperBLAST, CDD, Compare to cluster

TRPC_BACTN Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134}
260 amino acids: PaperBLAST, CDD, Compare to cluster

MONOMER-343 indole-3-glycerol phosphate synthase (EC 4.1.1.48)
PFams: IGPS
252 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/4 heteromeric)

PRAI-IGPS fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (EC 4.1.1.48; EC 5.3.1.24)
P00909 phosphoribosylanthranilate isomerase (EC 5.3.1.24)
PRAI-IGPS indole-3-glycerol phosphate synthase (EC 4.1.1.48; EC 5.3.1.24)
PFams: IGPS, PRAI
453 amino acids: PaperBLAST, CDD

P00937 Multifunctional tryptophan biosynthesis protein; EC 4.1.3.27; EC 4.1.1.48
PFams: GATase, Peptidase_C26, IGPS, QRPTase_C
484 amino acids: PaperBLAST, CDD

P49572 Indole-3-glycerol phosphate synthase, chloroplastic; IGPS; EC 4.1.1.48
PFams: IGPS
402 amino acids: PaperBLAST, CDD

B8DM44_DESVM Indole-3-glycerol-phosphate synthase; EC=4.1.1.48
321 amino acids: PaperBLAST, CDD