Other Characterized Proteins Similar to IGPS
Finding the characterized proteins for IGPS (indole-3-glycerol phosphate synthase) in L-tryptophan biosynthesis
Or see clustering for step IGPS
Or see all steps for L-tryptophan biosynthesis
Or cluster curated proteins matching a keyword
Definition of IGPS
- Curated proteins or TIGRFams with EC 4.1.1.48
- UniProt sequence E4PQZ8_MARAH: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|HAMAP-Rule:MF_00134};
- UniProt sequence B8DM44_DESVM: RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362}; EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
- UniProt sequence TRPC_BACTN: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
- UniProt sequence A0A560BXT3: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|HAMAP-Rule:MF_00134};
- UniProt sequence A0A166NT80_PSEFL: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|HAMAP-Rule:MF_00134};
- UniProt sequence A0A166NT80_PSEFL: RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00134}; Short=IGPS {ECO:0000256|HAMAP-Rule:MF_00134}; EC=4.1.1.48 {ECO:0000256|HAMAP-Rule:MF_00134};
- Ignore hits to items matching EC 4.1.3.27 when looking for 'other' hits
- Ignore hits to P24920 when looking for 'other' hits (phosphoribosylanthranilate isomerase (EC 5.3.1.24))
- Comment: Sometimes fused to anthranilate synthase subunits or known as trpC (if fused to PRAI). Ignore BRENDA::P24920 because annotated as phosphoribosylanthranilate isomerase but is also believed to be IGPS. And based on presence in Trp clusters and auxotrophic or cofit phenotypes, annotate somewhat diverged IGPS: HP15_3291 (E4PQZ8_MARAH), DvMF_1743 (B8DM44_DESVM), BT0529 (TRPC_BACTN), AZOBR_RS07450 (A0A560BXT3), Pf1N1B4_2549 (A0A166NT80_PSEFL), AO353_07210 (A0A0N9WG05_PSEFL).
Fetched 12 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 2 other characterized sequences. (Found 9 hits including self hits.)
Removing ignored items reduces this to 0 close sequences.
Close but ignored sequences
(Sequences that are similar to these will still be high-confidence candidates for IGPS.)
CH_122586 anthranilate synthase component 2; EC 4.1.3.27 from Emericella nidulans
PFams: GATase, IGPS, PRAI
768 amino acids: PaperBLAST, CDD, CharProtDB::CH_122586
53% identical to
TRPG_YEAST / P00937 Multifunctional tryptophan biosynthesis protein; EC 4.1.3.27; EC 4.1.1.48 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: GATase, Peptidase_C26, IGPS, QRPTase_C
484 amino acids: PaperBLAST, CDD
P24920 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Phytophthora parasitica
PFams: IGPS, PRAI
531 amino acids: PaperBLAST, CDD, BRENDA::P24920
40% identical to
A1KJ27 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis variant bovis BCG
A5U2W7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis H37Ra
P9WFX7 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) from Mycobacterium tuberculosis
PFams: IGPS
272 amino acids: PaperBLAST, CDD