Other Characterized Proteins Similar to PRAI
Finding the characterized proteins for PRAI (phosphoribosylanthranilate isomerase) in L-tryptophan biosynthesis
Or see clustering for step PRAI
Or see all steps for L-tryptophan biosynthesis
Or cluster curated proteins matching a keyword
Definition of PRAI
- Curated proteins or TIGRFams with EC 5.3.1.24
- UniProt sequence Q8AAD7_BACTN: RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000256|ARBA:ARBA00022272, ECO:0000256|HAMAP-Rule:MF_00135}; Short=PRAI {ECO:0000256|HAMAP-Rule:MF_00135}; EC=5.3.1.24 {ECO:0000256|ARBA:ARBA00012572, ECO:0000256|HAMAP-Rule:MF_00135};
- UniProt sequence A0A0H3CC53_CAUVN: RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000256|ARBA:ARBA00022272, ECO:0000256|HAMAP-Rule:MF_00135}; Short=PRAI {ECO:0000256|HAMAP-Rule:MF_00135}; EC=5.3.1.24 {ECO:0000256|ARBA:ARBA00012572, ECO:0000256|HAMAP-Rule:MF_00135};
- UniProt sequence TRPF_RHIME: RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000255|HAMAP-Rule:MF_00135}; Short=PRAI {ECO:0000255|HAMAP-Rule:MF_00135}; EC=5.3.1.24 {ECO:0000255|HAMAP-Rule:MF_00135};
- UniProt sequence A0A1L6JC25_9SPHN: RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000256|ARBA:ARBA00022272, ECO:0000256|HAMAP-Rule:MF_00135}; Short=PRAI {ECO:0000256|HAMAP-Rule:MF_00135}; EC=5.3.1.24 {ECO:0000256|ARBA:ARBA00012572, ECO:0000256|HAMAP-Rule:MF_00135};
- Ignore hits to items matching EC 5.3.1.16 when looking for 'other' hits
- Comment: PRAI is sometimes known as trpF or as part of trpC (if fused to IGPS). In Bacteroides thetaiotaomicron, BT0528 (Q8AAD7_BACTN) has a PRAI domain (PF00697), is auxotrophic, and clusters with trp synthesis genes Similarly, annotate CCNA_03659 (A0A0H3CC53_CAUVN), SMc02767 (TRPF_RHIME), and Ga0059261_0237 (A0A1L6JC25_9SPHN). Some bacteria have a bifunctional phosphoribosylanthranilate isomerase (EC 5.3.1.24) and isomerase in histidine biosynthesis (hisA, EC 5.3.1.16), for instance P16250. (In both reactions a N-modified-1-amino-ribofuranose-5-phosphate rearranges to a linear N-modified-1-amino-ribulose-5-phosphate.) So hits to hisA are ignored.
Fetched 18 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 0 other characterized sequences. (Found 14 hits including self hits.)