GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for trpA (indoleglycerol phosphate aldolase) in L-tryptophan biosynthesis

Or see other characterized proteins similar to trpA

Or see all steps for L-tryptophan biosynthesis

Or cluster curated proteins matching a keyword

Definition of trpA

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 251-269 amino acids (1/4 heteromeric)

A0A3N7DTH5 Tryptophan synthase alpha chain {ECO:0000256|HAMAP-Rule:MF_00131}; EC=4.2.1.20 {ECO:0000256|HAMAP-Rule:MF_00131}
255 amino acids: PaperBLAST, CDD, Compare to cluster

H0BV16 Tryptophan synthase alpha chain {ECO:0000256|HAMAP-Rule:MF_00131}; EC=4.2.1.20 {ECO:0000256|HAMAP-Rule:MF_00131}
269 amino acids: PaperBLAST, CDD, Compare to cluster

M4NLA4 Tryptophan synthase alpha chain {ECO:0000256|HAMAP-Rule:MF_00131}; EC=4.2.1.20 {ECO:0000256|HAMAP-Rule:MF_00131}
266 amino acids: PaperBLAST, CDD, Compare to cluster

Q9YGA9 tryptophan synthase subunit α (EC 4.1.2.8) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Q9YGA9 tryptophan synthase (subunit 1/2) (EC 4.2.1.20) from Thermococcus kodakarensis
PFams: Trp_syntA, Ribul_P_3_epim, His_biosynth
Heteromeric, 251 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 702-723 amino acids (not heteromeric)

CH_122413 bifunctional tryptophan synthase TRPB (from HMM only) from Emericella nidulans
PFams: Trp_syntA, PALP
723 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123254 likely tryptophan synthetase alpha chain (from HMM only) from Candida albicans
PFams: Trp_syntA, PALP
702 amino acids: PaperBLAST, CDD, Compare to cluster