Clusters of Characterized Proteins

Clustering the characterized proteins for trpD_2 (anthranilate phosphoribosyltransferase) in L-tryptophan biosynthesis

Or see other characterized proteins similar to trpD_2

Or see all steps for L-tryptophan biosynthesis

Or cluster curated proteins matching a keyword

Definition of trpD_2

• Curated proteins or TIGRFams with EC 2.4.2.18
• Ignore hits to items matching EC 4.1.3.27 when looking for 'other' hits
• Comment: Often fused to anthranilate synthase so ignore that (i.e., P00500 is labeled in BRENDA as a subunit of anthranilate synthase; it is probably anthranilate phosphoribosyltransferase as well)

Fetched 8 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 8 of these sequences

Found 2 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 329-380 amino acids (not heteromeric)

P50384 Anthranilate phosphoribosyltransferase; EC 2.4.2.18
P50384 anthranilate phosphoribosyltransferase (EC 2.4.2.18)
PFams: Glycos_trans_3N, Glycos_transf_3
345 amino acids: PaperBLAST, CDD, Compare to cluster

P07285 Anthranilate phosphoribosyltransferase; EC 2.4.2.18
PFams: Glycos_trans_3N, Glycos_transf_3
380 amino acids: PaperBLAST, CDD, Compare to cluster

P83827 Anthranilate phosphoribosyltransferase; EC 2.4.2.18
Q5SH88 Anthranilate phosphoribosyltransferase; EC 2.4.2.18
PFams: Glycos_trans_3N, Glycos_transf_3
329 amino acids: PaperBLAST, CDD, Compare to cluster

Q8PD71 Anthranilate phosphoribosyltransferase; EC 2.4.2.18
PFams: Glycos_trans_3N, Glycos_transf_3
345 amino acids: PaperBLAST, CDD, Compare to cluster

Q8YXQ9 Anthranilate phosphoribosyltransferase 2; EC 2.4.2.18
PFams: Glycos_trans_3N, Glycos_transf_3
362 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 531-531 amino acids (1/2 heteromeric)

ANTHRANSYNCOMPII-MONOMER anthranilate synthase subunit TrpD (EC 2.4.2.18; EC 4.1.3.27)
P00904 Bifunctional protein TrpGD; EC 4.1.3.27; EC 2.4.2.18
ANTHRANSYNCOMPII-MONOMER anthranilate synthase component II (EC 2.4.2.18)
PFams: GATase, Peptidase_C26, Glycos_trans_3N, Glycos_transf_3
Heteromeric, 531 amino acids: PaperBLAST, CDD, Compare to cluster

P00905 Bifunctional protein TrpGD; EC 4.1.3.27; EC 2.4.2.18
PFams: GATase, Peptidase_C26, Glycos_trans_3N, Glycos_transf_3
531 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18
P9WFX5 anthranilate phosphoribosyltransferase (EC 2.4.2.18)
PFams: Glycos_trans_3N, Glycos_transf_3
370 amino acids: PaperBLAST, CDD
(similar to BRENDA::P50384 from Cluster 1, but similarity to seed sequence is below thresholds)