Other Characterized Proteins Similar to trpE

Finding the characterized proteins for trpE (anthranilate synthase subunit TrpE) in L-tryptophan biosynthesis

Or see clustering for step trpE

Or see all steps for L-tryptophan biosynthesis

Or cluster curated proteins matching a keyword

Definition of trpE

• HMM TIGR00564
• HMM TIGR00565
• HMM TIGR01820
• Curated proteins matching anthranilate synthase component 1
• Curated proteins matching anthranilate synthase component I
• Curated proteins matching anthranilate synthase alpha subunit
• UniProt sequence Q8AAD3_BACTN: SubName: Full=Anthranilate synthase component I {ECO:0000313|EMBL:AAO75639.1};
• UniProt sequence A0A1X9ZB07_9SPHI: SubName: Full=Anthranilate synthase component I {ECO:0000313|EMBL:ARS42349.1};
• UniProt sequence Q72EV3_DESVH: SubName: Full=Anthranilate synthase, component I {ECO:0000313|EMBL:AAS94948.1};
• UniProt sequence B8DM47_DESVM: SubName: Full=Anthranilate synthase {ECO:0000313|EMBL:ACL08691.1}; EC=4.1.3.27 {ECO:0000313|EMBL:ACL08691.1};
• Ignore hits to items matching EC 4.1.3.27 when looking for 'other' hits
• Comment: This component of anthranilate synthase is also known as the alpha subunit or component I. BT0532 (Q8AAD3_BACTN) and CA265_RS22890 (A0A1X9ZB07_9SPHI) are also component I. Similarly for DVU0465 (Q72EV3_DESVH) and DvMF_1746 (B8DM47_DESVM). Some related proteins have EC 2.6.1.85 which should perhaps be ignored.

Fetched 17 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 7 other characterized sequences. (Found 20 hits including self hits.)

Removing ignored items reduces this to 1 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for trpE.)

P28820 4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase) (EC 2.6.1.123) from Bacillus subtilis (strain 168)
PABB_BACSU / P28820 Aminodeoxychorismate synthase component 1; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 1; EC 2.6.1.85 from Bacillus subtilis (strain 168)
P28820 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) (EC 2.6.1.123); aminodeoxychorismate synthase (EC 2.6.1.85) from Bacillus subtilis
GB|BAA05309.1 para-aminobenzoate synthase, component 1; EC 2.6.1.85 from Bacillus subtilis
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 470 amino acids: PaperBLAST, CDD, BRENDA::P28820
41% identical to

Q08653 anthranilate synthase component I (EC 4.1.3.27) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: Anth_synt_I_N, Chorismate_bind
461 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for trpE.)

Q5XLF3 anthranilate synthase (EC 4.1.3.27) from Camptotheca acuminata
PFams: Anth_synt_I_N, Chorismate_bind
581 amino acids: PaperBLAST, CDD, BRENDA::Q5XLF3
73% identical to

TRPE_ARATH / P32068 Anthranilate synthase alpha subunit 1, chloroplastic; Anthranilate synthase component 1-1; Anthranilate synthase component I-1; Protein A-METHYL TRYPTOPHAN RESISTANT 1; Protein JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; Protein TRYPTOPHAN BIOSYNTHESIS 5; Protein WEAK ETHYLENE INSENSITIVE 2; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 595 amino acids: PaperBLAST, CDD

Q9AW95 anthranilate synthase (EC 4.1.3.27) from Catharanthus roseus
PFams: Anth_synt_I_N, Chorismate_bind
608 amino acids: PaperBLAST, CDD, BRENDA::Q9AW95
69% identical to

TRPE_ARATH / P32068 Anthranilate synthase alpha subunit 1, chloroplastic; Anthranilate synthase component 1-1; Anthranilate synthase component I-1; Protein A-METHYL TRYPTOPHAN RESISTANT 1; Protein JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; Protein TRYPTOPHAN BIOSYNTHESIS 5; Protein WEAK ETHYLENE INSENSITIVE 2; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 595 amino acids: PaperBLAST, CDD

Q41156 anthranilate synthase α subunit (EC 4.1.3.27) from Ruta graveolens
PFams: Anth_synt_I_N, Chorismate_bind
613 amino acids: PaperBLAST, CDD, metacyc::MONOMER-14031
69% identical to

TRPE_ARATH / P32068 Anthranilate synthase alpha subunit 1, chloroplastic; Anthranilate synthase component 1-1; Anthranilate synthase component I-1; Protein A-METHYL TRYPTOPHAN RESISTANT 1; Protein JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; Protein TRYPTOPHAN BIOSYNTHESIS 5; Protein WEAK ETHYLENE INSENSITIVE 2; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 595 amino acids: PaperBLAST, CDD

Q5XLF2 anthranilate synthase (EC 4.1.3.27) from Camptotheca acuminata
PFams: Anth_synt_I_N, Chorismate_bind
579 amino acids: PaperBLAST, CDD, BRENDA::Q5XLF2
68% identical to

TRPE_ARATH / P32068 Anthranilate synthase alpha subunit 1, chloroplastic; Anthranilate synthase component 1-1; Anthranilate synthase component I-1; Protein A-METHYL TRYPTOPHAN RESISTANT 1; Protein JASMONATE-INDUCED DEFECTIVE LATERAL ROOT 1; Protein TRYPTOPHAN BIOSYNTHESIS 5; Protein WEAK ETHYLENE INSENSITIVE 2; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 595 amino acids: PaperBLAST, CDD

P9WFX2 anthranilate synthase (EC 4.1.3.27) from Mycobacterium tuberculosis
P9WFX3 anthranilate synthase (EC 4.1.3.27) from Mycobacterium tuberculosis
PFams: Anth_synt_I_N, Chorismate_bind
516 amino acids: PaperBLAST, CDD, BRENDA::P9WFX2
46% identical to

P20580 anthranilate synthase α subunit (EC 4.1.3.27) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
TRPE_PSEAE / P20580 Anthranilate synthase component 1; AS; ASI; EC 4.1.3.27 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
P20580 anthranilate synthase (subunit 1/2) (EC 4.1.3.27) from Pseudomonas aeruginosa
PFams: Anth_synt_I_N, Chorismate_bind
Heteromeric, 492 amino acids: PaperBLAST, CDD

Q9YGB3 anthranilate synthase (EC 4.1.3.27) from Thermococcus kodakarensis
PFams: Anth_synt_I_N, Chorismate_bind
433 amino acids: PaperBLAST, CDD, BRENDA::Q9YGB3
42% identical to

Q08653 anthranilate synthase component I (EC 4.1.3.27) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PFams: Anth_synt_I_N, Chorismate_bind
461 amino acids: PaperBLAST, CDD