Clusters of Characterized Proteins

Clustering the characterized proteins for aro-dehydr (arogenate dehydrogenase) in L-tyrosine biosynthesis

Or see other characterized proteins similar to aro-dehydr

Or see all steps for L-tyrosine biosynthesis

Or cluster curated proteins matching a keyword

Definition of aro-dehydr

• Curated proteins or TIGRFams with EC 1.3.1.78
• Curated proteins or TIGRFams with EC 1.3.1.43
• Curated proteins or TIGRFams with EC 1.3.1.78
• UniProt sequence Q8A0T8_BACTN: SubName: Full=Chorismate mutase/prephenate dehydratase (TyrA) {ECO:0000313|EMBL:AAO79038.1};
• Curated sequence 209400: prephenate and/or arogenate dehydrogenase
• UniProt sequence D8IR44_HERSS: SubName: Full=Prephenate dehydrogenase protein {ECO:0000313|EMBL:ADJ65170.1}; EC=1.3.1.12 {ECO:0000313|EMBL:ADJ65170.1};
• UniProt sequence A0A1L6J750: SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:PJI88995.1};
• Ignore hits to items matching EC 1.3.1.12 when looking for 'other' hits
• Ignore hits to items matching EC 1.3.1.13 when looking for 'other' hits
• Comment: Multiple EC numbers for varying use of NAD(P)H BT3933 and DVU0464 and HSERO_RS18425 are included but their specificity is uncertain

Fetched 9 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 2 clusters of similar sequences. Another 5 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 358-360 amino acids (not heteromeric)

Q9LMR3 arogenate dehydrogenase (EC 1.3.1.78) from Arabidopsis thaliana
TYRA2_ARATH / Q9LMR3 Arogenate dehydrogenase 2, chloroplastic; TyrAAT2; EC 1.3.1.78 from Arabidopsis thaliana (Mouse-ear cress)
Q9LMR3 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Arabidopsis thaliana
PFams: F420_oxidored, PDH_N
358 amino acids: PaperBLAST, CDD, Compare to cluster

B4FY98 arogenate dehydrogenase 1 (EC 1.3.1.43) from Zea mays
PFams: F420_oxidored, NAD_binding_2, PDH_N
360 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 293-295 amino acids (not heteromeric)

TYRC_ZYMMO / Q04983 Cyclohexadienyl dehydrogenase; Arogenate dehydrogenase; ADH; Prephenate dehydrogenase; PDH; EC 1.3.1.43; EC 1.3.1.12 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
PFams: 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2, PDH_N, PDH_C
293 amino acids: PaperBLAST, CDD, Compare to cluster

D8IR44_HERSS Prephenate dehydrogenase protein; EC=1.3.1.12
295 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/5 heteromeric)

P73906 arogenate dehydrogenase monomer (EC 1.3.1.78) from Synechocystis sp. (strain PCC 6803 / Kazusa)
P73906 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Synechocystis sp. PCC 6803
PFams: F420_oxidored, NAD_binding_2, PDH_N, PDH_C
279 amino acids: PaperBLAST, CDD

Q944B6 arogenate dehydrogenase (EC 1.3.1.78) from Arabidopsis thaliana
TYRA1_ARATH / Q944B6 Arogenate dehydrogenase 1, chloroplastic; TYRATC; TyrAAT1; EC 1.3.1.78 from Arabidopsis thaliana (Mouse-ear cress)
Q944B6 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Arabidopsis thaliana
PFams: F420_oxidored, PDH_N, 2-Hacid_dh_C, F420_oxidored, NAD_binding_2, PDH_N
640 amino acids: PaperBLAST, CDD

A0A1L6J750 Prephenate dehydrogenase
249 amino acids: PaperBLAST, CDD

Q8A0T8_BACTN Chorismate mutase/prephenate dehydratase (TyrA)
257 amino acids: PaperBLAST, CDD

DVU0464 prephenate and/or arogenate dehydrogenase from Desulfovibrio vulgaris Hildenborough JW710
PFams: PDH_N
255 amino acids: PaperBLAST, CDD