Other Characterized Proteins Similar to pre-dehydr
Finding the characterized proteins for pre-dehydr (prephenate dehydrogenase) in L-tyrosine biosynthesis
Or see clustering for step pre-dehydr
Or see all steps for L-tyrosine biosynthesis
Or cluster curated proteins matching a keyword
Definition of pre-dehydr
- Curated proteins or TIGRFams with EC 1.3.1.12
- Curated proteins or TIGRFams with EC 1.3.1.13
- UniProt sequence Q8A0T8_BACTN: SubName: Full=Chorismate mutase/prephenate dehydratase (TyrA) {ECO:0000313|EMBL:AAO79038.1};
- Curated sequence 209400: prephenate and/or arogenate dehydrogenase
- UniProt sequence D8IR44_HERSS: SubName: Full=Prephenate dehydrogenase protein {ECO:0000313|EMBL:ADJ65170.1}; EC=1.3.1.12 {ECO:0000313|EMBL:ADJ65170.1};
- UniProt sequence A0A1L6J750: SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:PJI88995.1};
- Ignore hits to items matching EC 1.3.1.78 when looking for 'other' hits
- Ignore hits to items matching EC 1.3.1.43 when looking for 'other' hits
- Ignore hits to items matching EC 1.3.1.78 when looking for 'other' hits
- UniProt sequence D4GXG3: SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:ADE03239.1}; EC=1.3.1.12 {ECO:0000313|EMBL:ADE03239.1};
- Ignore hits to P06959 when looking for 'other' hits (pyruvate dehydrogenase system (EC 1.2.1.104); prephenate dehydrogenase (EC 1.3.1.12); dihydrolipoyllysine-residue acetyltransferase (EC 2.3.1.12). pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2. dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; EC 2.3.1.12. pyruvate dehydrogenase, E2 subunit (EC 2.3.1.12). pyruvate dehydrogenase E2 subunit (EC 2.3.1.12))
- UniProt sequence Q92MG1: SubName: Full=Cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase {ECO:0000313|EMBL:CAC47240.1};
- Predicted: UniProt sequence E1QE65: SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:ADK83851.1};
- Comment: prephenate dehydrogenase and arogenate dehydrogenase are difficult to distinguish. 1.3.1.12 and 1.3.1.13 vary by NAD(P)H cofactor. BT3933 (Q8A0T8_BACTN), DVU0464 (Q72EV4_DESVH), HSERO_RS18425 (D8IR44_HERSS), and Ga0059261_2298 (A0A1L6J750) are auxotrophic and have prephenate dehydrogenase domains (PF02153), but their specificity is unclear. HVO_1312 (D4GXG3) is auxotrophic for tyrosine and is probably a prephenate dehydrogenase (PMC4300041). P06959 is misannotated in BRENDA and is ignored. Ac3H11_2575 (A0A162F6L0) has auxotrophic phenotypes but its specificity is unclear. Q92MG1 was confirmed by binding tyrosine in a crystal structure (PDB:4wji). In Desulfarculus, the enzyme is a bit diverged (E1QE65), but has conserved tyrosine binding residues and is in a conserved operon with aromatic amino acid biosynthesis genes.
Fetched 25 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 4 other characterized sequences. (Found 23 hits including self hits.)
Removing ignored items reduces this to 1 close sequences.
Close sequences
(Sequences that are similar to these will not be high-confidence candidates for pre-dehydr.)
B6SS03 arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) from Zea mays
PFams: F420_oxidored, PDH_N
349 amino acids: PaperBLAST, CDD, BRENDA::B6SS03
50% identical to
G7J2E9 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Medicago truncatula
PFams: F420_oxidored, PDH_N
268 amino acids: PaperBLAST, CDD
Close but ignored sequences
(Sequences that are similar to these will still be high-confidence candidates for pre-dehydr.)
Q944B6 arogenate dehydrogenase (EC 1.3.1.78) from Arabidopsis thaliana
TYRA1_ARATH / Q944B6 Arogenate dehydrogenase 1, chloroplastic; TYRATC; TyrAAT1; EC 1.3.1.78 from Arabidopsis thaliana (Mouse-ear cress)
Q944B6 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Arabidopsis thaliana
PFams: F420_oxidored, PDH_N, 2-Hacid_dh_C, F420_oxidored, NAD_binding_2, PDH_N
640 amino acids: PaperBLAST, CDD, BRENDA::Q944B6
54% identical to
G7J2E9 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Medicago truncatula
PFams: F420_oxidored, PDH_N
268 amino acids: PaperBLAST, CDD
Q9LMR3 arogenate dehydrogenase (EC 1.3.1.78) from Arabidopsis thaliana
TYRA2_ARATH / Q9LMR3 Arogenate dehydrogenase 2, chloroplastic; TyrAAT2; EC 1.3.1.78 from Arabidopsis thaliana (Mouse-ear cress)
Q9LMR3 arogenate dehydrogenase (NADP+) (EC 1.3.1.78) from Arabidopsis thaliana
PFams: F420_oxidored, PDH_N
358 amino acids: PaperBLAST, CDD, BRENDA::Q9LMR3
50% identical to
G7J2E9 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Medicago truncatula
PFams: F420_oxidored, PDH_N
268 amino acids: PaperBLAST, CDD
B4FY98 arogenate dehydrogenase 1 (EC 1.3.1.43) from Zea mays
PFams: F420_oxidored, NAD_binding_2, PDH_N
360 amino acids: PaperBLAST, CDD, metacyc::MONOMER-8134
52% identical to
G7J2E9 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Medicago truncatula
PFams: F420_oxidored, PDH_N
268 amino acids: PaperBLAST, CDD