Other Characterized Proteins Similar to ald-dh-CoA

GapMind for catabolism of small carbon sources

Other Characterized Proteins Similar to ald-dh-CoA

Finding the characterized proteins for ald-dh-CoA (acetaldehyde dehydrogenase, acylating) in 4-hydroxybenzoate catabolism

Or see clustering for step ald-dh-CoA

Or see all steps for 4-hydroxybenzoate catabolism

Or cluster curated proteins matching a keyword

Definition of ald-dh-CoA

Curated proteins or TIGRFams with EC 1.2.1.10
Ignore hits to items matching 1.1.1.1 when looking for 'other' hits
Ignore hits to items matching 1.1.1.71 when looking for 'other' hits
Ignore hits to items matching 1.2.1.57 when looking for 'other' hits
Ignore hits to Q2XQZ7 when looking for 'other' hits (4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39))
Comment: Many enzymes are multifunctional alcohol/acetaldehyde dehydrogenases, and many close homologs have just one annotation. EC 1.2.1.57 is acylating butanal dehydrogenase, which may also act on acetaldehyde. Q2XQZ7 is probably misannotated.

Fetched 23 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 7 other characterized sequences. (Found 30 hits including self hits.)

Removing ignored items reduces this to 2 close sequences.

There are also 3 HMM-only high-coverage hits.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for ald-dh-CoA.)

A9KN57 aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Lachnoclostridium phytofermentans
PFams: Aldedh
462 amino acids: PaperBLAST, CDD, BRENDA::A9KN57
50% identical to

B0K315 acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacter sp.
PFams: Aldedh
466 amino acids: PaperBLAST, CDD

Q9XDN1 CoA-dependent propanal dehydrogenase (EC 1.2.1.87) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: Aldedh
464 amino acids: PaperBLAST, CDD, metacyc::STM2051-MONOMER
48% identical to

B0K315 acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacter sp.
PFams: Aldedh
466 amino acids: PaperBLAST, CDD

HMM-only sequences

(Since these sequences' annotations are outside the definition for ald-dh-CoA, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

Q0S816 propanal dehydrogenase (EC 1.2.1.87) from Rhodococcus jostii (strain RHA1)
PFams: Semialdhyde_dh, AcetDehyd-dimer
300 amino acids: PaperBLAST, CDD

P9WQH3 propanal dehydrogenase (EC 1.2.1.87) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Semialdhyde_dh, AcetDehyd-dimer
303 amino acids: PaperBLAST, CDD

Q83VZ4 propanal dehydrogenase (EC 1.2.1.87) from Comamonas testosteroni
PFams: Semialdhyde_dh, AcetDehyd-dimer
307 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for ald-dh-CoA.)

A0A0H3W5V0 alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Thermoanaerobacterium saccharolyticum
PFams: Aldedh, Fe-ADH, Fe-ADH_2, Fe-ADH_2
859 amino acids: PaperBLAST, CDD, BRENDA::A0A0H3W5V0
99% identical to

A0A0H3W5K4 acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacterium saccharolyticum
I3VSF1 alcohol dehydrogenase (EC 1.1.1.1); L-lactate dehydrogenase (EC 1.1.1.27); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacterium saccharolyticum
PFams: Aldedh, Fe-ADH, Fe-ADH_2, Fe-ADH_2
859 amino acids: PaperBLAST, CDD

B0KBJ9 alcohol dehydrogenase (EC 1.1.1.1) from Thermoanaerobacter pseudethanolicus
PFams: Aldedh, Fe-ADH, Fe-ADH_2, Fe-ADH_2
872 amino acids: PaperBLAST, CDD, BRENDA::B0KBJ9
99% identical to

B0K4A2 alcohol dehydrogenase (EC 1.1.1.1); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacter sp. X514
PFams: Aldedh, Fe-ADH, Fe-ADH_2, Fe-ADH_2
872 amino acids: PaperBLAST, CDD

Q0PH30 alcohol dehydrogenase (EC 1.1.1.1) from Thermoanaerobacter ethanolicus
PFams: Aldedh, Fe-ADH, Fe-ADH_2, Fe-ADH_2
874 amino acids: PaperBLAST, CDD, BRENDA::Q0PH30
97% identical to

Q2XQZ7 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Pseudomonas sp.
PFams: Semialdhyde_dh, AcetDehyd-dimer
307 amino acids: PaperBLAST, CDD, BRENDA::Q2XQZ7
79% identical to

Q83VZ4 propanal dehydrogenase (EC 1.2.1.87) from Comamonas testosteroni
PFams: Semialdhyde_dh, AcetDehyd-dimer
307 amino acids: PaperBLAST, CDD

Q9ANR5 aldehyde dehydrogenase/alcohol dehydrogenase (EC 1.2.1.57) from Clostridium acetobutylicum
PFams: Aldedh, Fe-ADH, Fe-ADH_2, Fe-ADH_2
858 amino acids: PaperBLAST, CDD, metacyc::MONOMER-15847
66% identical to

P33744 alcohol/aldehyde dehydrogenase (EC 1.1.1.1; EC 1.2.1.10; EC 1.2.1.57) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
ADHE_CLOAB / P33744 Aldehyde-alcohol dehydrogenase; AAD; EC 1.1.1.1; EC 1.2.1.3 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
GB|AAD04638.1 aldehyde-alcohol dehydrogenase; EC 1.1.1.1; EC 1.2.1.10 from Clostridium acetobutylicum ATCC 824
PFams: Aldedh, Fe-ADH
862 amino acids: PaperBLAST, CDD